Catalog No.
Product Name
Application
Product Information
Citations
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RSV Polymerase Inhibitor
JNJ-8003 is a highly potent, orally active non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase, exhibiting an IC50 of 0.29 nM. It specifically targets the L protein of the polymerase complex, effectively blocking the transcription and replication of the viral genome by inhibiting RNA-dependent RNA polymerase (RdRp) activity, with an IC50 of 0.67 nM. In vitro studies demonstrate subnanomolar efficacy, and it has shown significant effectiveness in mouse and neonatal lamb models. JNJ-8003 is a valuable reagent for investigating RSV biology and developing antiviral therapies. -
Purine Nucleoside Analog
2-Thiouridine is a purine nucleoside analog that enhances the stability of U:A base pairs while destabilizing U:G wobble base pairs. This modification significantly boosts the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. Additionally, 2-Thiouridine exhibits notable antiviral activity against a range of positive-sense single-stranded RNA viruses, including Dengue Virus (DENV2), Zika Virus (ZIKV), Yellow Fever Virus (YFV), Japanese Encephalitis Virus (JEV), West Nile Virus (WNV), Chikungunya Virus (CHIKV), and various human coronaviruses, such as SARS-CoV and MERS-CoV. -
Antibiotic
Rifalazil, a rifamycin derivative, targets bacterial DNA-dependent RNA polymerase, specifically inhibiting the β-subunit to disrupt RNA synthesis and induce bacterial cell death. This antibiotic demonstrates exceptional potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, Chlamydia pneumoniae, and Chlamydia trachomatis, with MIC values ranging from 0.00025 to 0.0025 μg/ml. Rifalazil shows promising potential for applications in treating Chlamydia infections, Clostridium difficile-associated diarrhea (CDAD), and tuberculosis (TB). -
Antibiotic
Phleomycin is a copper-dependent antibiotic known for its DNA-damaging properties. It exerts its biological activity by binding to DNA and generating reactive oxygen species (ROS) in the presence of reducing agents, leading to both single-strand and double-strand breaks. This compound is extensively utilized in cancer research, microbial genetic transformation, serving as a screening marker to enhance fungal transformation efficiency, and the study of DNA repair mechanisms. -
HBV Inhibitor
Bersacapavir is an HBV capsid assembly modulator that targets hepatitis B virus (HBV) replication. It exhibits a dual mechanism of action by forming complete genome-free empty capsids and inhibiting the de novo synthesis of covalently closed circular DNA (cccDNA). This compound is valuable for research applications focusing on HBV infection and the development of antiviral therapies. -
Quinolone Antibiotic
Danofloxacin is a quinolone antibiotic that primarily targets bacterial DNA gyrase, leading to the inhibition of DNA replication and transcription. This mechanism disrupts the growth and proliferation of bacteria. Danofloxacin is effective against a range of bacterial infections, including those caused by Escherichia coli, Mycoplasma, and other pathogenic organisms, making it a valuable tool for related research applications. -
DENV Polymerase Inhibitor
NITD-2 is a selective inhibitor of dengue virus (DENV) polymerase, specifically targeting the RNA-dependent RNA polymerase (RdRp) to impede RNA elongation. This compound exhibits potent antiviral activity against DENV, making it a valuable tool for research focused on understanding dengue virus replication and developing therapeutic strategies. Its limited ability to penetrate cell membranes can be an important consideration for in vitro experimental design. -
Macrolide Antibiotic
Erythromycin lactobionate is a macrolide antibiotic that targets bacterial 50S ribosomal subunits, inhibiting RNA-dependent protein synthesis through obstruction of transpeptidation and/or translocation processes. This compound demonstrates a broad spectrum of antimicrobial activity, making it valuable for various bacterial infections. Additionally, erythromycin lactobionate has shown potential antitumor and neuroprotective effects, presenting opportunities for research in oncology and neurobiology. -
HBV RNase H Inhibitor
β-Thujaplicinol is a potent inhibitor of hepatitis B virus (HBV) ribonuclease H, showing inhibitory effects on HBV genotypes D and H with IC50 values of 5.9 and 2.3 μM, respectively. Its primary mechanism involves disrupting the enzymatic activity of HBV RNase H, making it a valuable tool for researching HBV replication and pathogenesis. This compound is suitable for studies focused on antiviral development and the therapeutic targeting of HBV. -
HBV inhibitor
ALG-000184 is an orally bioavailable inhibitor targeting hepatitis B virus (HBV). It functions as a prodrug to ALG-001075 and effectively reduces HBV DNA production in liver cells. This compound is intended for research applications in chronic hepatitis B studies, facilitating investigations into therapeutic strategies against HBV infection.
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Dengue Virus Protease Inhibitor
SP-471P is a potent inhibitor of the dengue virus (DENV) protease, exhibiting EC50 values of 5.9 μM, 1.4 μM, 5.1 μM, and 1.7 μM against DENV1, DENV2, DENV3, and DENV4, respectively, with a CC50 exceeding 100 μM. This compound effectively reduces DENV viral RNA synthesis, making it a valuable tool for research in dengue virus biology and antiviral therapeutic development. -
Antibiotic
Pefloxacin is a broad-spectrum antibiotic that targets DNA gyrase, effectively inhibiting DNA replication. It exhibits significant antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis, with MIC90 values of 0.12, 4, and 16 mg/L, respectively. In addition to its antibacterial properties, Pefloxacin has demonstrated efficacy in reducing Plasmodium yoelii infections and may enhance UVA-induced edema and immunosuppression. This compound is suitable for various infection-related research applications. -
Bacteria Antibiotic
Nogalamycin is an anthracyclinone antibiotic that primarily targets Gram-positive bacteria. It exhibits significant antibacterial activity along with cytotoxic effects against specific tumor cells. Derived from Streptomyces nogalater var. nogalater, Nogalamycin selectively inhibits RNA synthesis by binding to the DNA template. This compound is valuable for research into anticancer therapeutics and bacterial resistance mechanisms. -
HCV Inhibitor
TTP-8307 is a potent HCV inhibitor that disrupts the replication of various rhino- and enteroviruses. It specifically inhibits coxsackievirus B3 (CVB3) with an EC50 value of 1.2 μM, alongside poliovirus, by interfering with viral RNA synthesis. The compound exerts its antiviral effects through interaction with oxysterol-binding protein (OSBP), making it a valuable tool for research in virology and antiviral drug development. -
Antibacterial Agent
Ostruthin is a natural coumarin compound that exerts antibacterial and antimycobacterial activities. It effectively inhibits the growth of mycobacteria and Staphylococcus aureus, making it valuable in studies of bacterial pathogenesis. Additionally, ostruthin suppresses vascular smooth muscle cell proliferation and de novo DNA synthesis, positioning it as a pertinent tool for research related to mycobacterial infections and cardiovascular as well as cerebrovascular diseases. -
HBV Replication Inhibitor
AT-130 is a phenylpropenamide derivative that serves as a potent non-nucleoside inhibitor of hepatitis B virus (HBV) replication. It effectively inhibits viral DNA synthesis, exhibiting an EC50 of 0.13 μM against both wild-type and mutant strains of HBV. AT-130 demonstrates significant anti-HBV activity in hepatoma cell lines, making it a valuable tool for research focused on HBV infection and treatment strategies. -
Ansamycin Antibiotic
Rifamycin is an orally active ansamycin antibiotic that primarily inhibits DNA-dependent RNA synthesis. It demonstrates significant antibacterial activity against Mycobacterium tuberculosis and can also affect hepatic bile acid metabolism. Additionally, Rifamycin exhibits anti-inflammatory properties, making it useful in the study of infections caused by Mycobacterium tuberculosis and Bacteroides fragilis, as well as in research involving lipopolysaccharide-induced inflammation. -
Bacterial Inhibitor
Mequindox is an antimicrobial agent that functions as a bacterial inhibitor by selectively targeting and inhibiting DNA synthesis. This compound demonstrates significant genotoxic and carcinogenic effects in murine models, making it a valuable tool for studying bacterial resistance mechanisms and the potential impacts of antimicrobial agents on genetic material. Its applications extend to research on the safety and efficacy of antimicrobial treatments in various biological systems. -
Bacterial Inhibitor
Silver sulfadiazine is a sulfonamide antibiotic that functions as a bacterial inhibitor through dual mechanisms. The sulfa moiety inhibits bacterial folate absorption, thereby disrupting essential DNA synthesis. Additionally, silver ions released from silver sulfadiazine bind to and disrupt DNA structures, preventing bacterial DNA replication. This compound is widely used in research applications focusing on bacterial growth inhibition and antimicrobial studies. -
HBV Inhibitor
HBV-IN-4 is a phthalazinone derivative that functions as a potent inhibitor of HBV DNA replication, exhibiting an IC50 value of 14 nM. This compound effectively induces the formation of genome-free capsids, demonstrating substantial anti-HBV activity. Its applications include research into therapeutic strategies for hepatitis B virus infections. -
Antibiotic
Holomycin is a secondary metabolite belonging to the dithiolopyrrolone class, recognized for its broad-spectrum antibiotic properties. It exhibits notable antitumor activity and functions by inhibiting RNA synthesis in vivo. Holomycin serves as a valuable tool in pharmaceutical research, particularly in studies related to antimicrobial resistance and cancer therapeutics. -
Antibacterial Agent
Amicoumacin B is an antibacterial agent produced by the actinomycete strain 04-5195T, primarily targeting bacterial quorum sensing mechanisms. It demonstrates significant inhibitory activity against Chromobacterium violaceum, with a minimum inhibitory concentration (MIC) of 250 µg/mL. Additionally, Amicoumacin B upregulates the expression of bone morphogenetic protein 2 (BMP-2) while simultaneously inhibiting the expression of essential quorum sensing operons vioA, vioB, vioD, and vioE, and enhancing vioC expression. These properties make Amicoumacin B a valuable tool in microbiological research and the study of bacterial communication. -
Antibiotic
10,11-Dehydrocurvularin is an antibiotic derived from fungi, known for its ability to activate the heat shock response. This compound exhibits significant inhibition of the TGF-β signaling pathway, demonstrating anti-tumorigenic properties. Its biological activities make it a valuable reagent for research in antibiotic efficacy and cancer biology. -
Antitumor Antibiotic
Dinactin is an antibiotic ionophore derived from Streptomyces species, primarily targeting the Wnt/β-catenin signaling pathway in cancer cells. This compound exhibits significant inhibition of HCT-116 cell proliferation, with an IC50 value of 1.1 μM, demonstrating its anti-proliferative effects in an apoptosis-independent manner. Additionally, Dinactin serves as a valuable tool in research related to neuropathic pain. -
Antitumor Antibiotic
Sibiromycin is a glycosylated pyrrolobenzodiazepine (PBD) that functions as a potent antitumor antibiotic. It exerts its biological activity by covalently binding to DNA in the minor groove, specifically targeting the amino group of guanine. This mechanism contributes to its effectiveness in cancer research, making it a valuable tool for studies involving DNA interactions and antitumor mechanisms. -
Antineoplastic Antibiotic
Cytogenin, an antineoplastic antibiotic, demonstrates significant antitumor activity by inhibiting the growth of Ehrlich ascites tumors in mouse models. This compound also regulates inflammatory cytokines, effectively reducing levels of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and interleukin-6 (IL-6) in murine macrophages. Additionally, Cytogenin exhibits antidiabetic effects, making it a valuable reagent for research in cancer biology and inflammation. -
Larvicide/Antiviral
Cappariloside A is a potent larvicide primarily targeting Aedes aegypti larvae, demonstrating significant larvicidal activity while inhibiting larval glutathione-S-transferase activity. Additionally, it exhibits antiviral effects by decreasing phosphorylated STAT1 levels, inhibiting the replication of various influenza viruses, including H1N1 and H3N2, and downregulating key pro-inflammatory cytokines such as IL-6 and IFN-β. Cappariloside A is valuable for research involving larvicidal strategies and the investigation of antiviral responses in influenza virus infections. -
HSV Inhibitor
Denotivir is an orally active antiviral agent targeting herpes simplex virus (HSV) and varicella-zoster virus (VZV). It exhibits significant inhibition of viral proliferation and demonstrates anti-cancer properties, influencing the growth of various cancer cell lines. Additionally, Denotivir plays a role in immunosuppression by inhibiting the generation of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6, making it relevant for research in virology and oncology. -
HEVA71/PTP1B Inhibitor
Prunin is a potent inhibitor of human enterovirus A71 (HEVA71) and demonstrates strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 value of 5.5 μM. This compound has significant potential for research applications in virology and metabolic disease studies, particularly in elucidating the roles of HEVA71 and PTP1B in cellular signaling pathways and disease mechanisms. -
Bacterial Inhibitor
Fenvalerate is a highly effective bacterial inhibitor, primarily functioning as a protein phosphatase 2B (calcineurin) inhibitor, with an IC50 of 2-4 nM for PP2B-Aα. As a pyrethroid ester, it exhibits significant insecticidal and acaricidal properties. This compound is utilized in various research applications to study protein phosphatase signaling pathways and to explore potential therapeutic targets in bacterial infections. -
Nephrotoxin
Orellanine is a potent fungal nephrotoxin primarily known for its mechanism as a competitive inhibitor of alkaline phosphatase. This compound effectively induces apoptosis in proximal tubular cells and clear cell renal cell carcinoma (ccRCC) cell lines. Orellanine serves as a valuable tool for research focused on nephrotoxicity and the pathophysiology of ccRCC. -
Antibiotic
Fostriecin is a triene antibiotic that primarily targets topoisomerase II and inhibits protein phosphatase PP2A. It exhibits potent antibacterial activity and has been employed in research focused on mechanisms of antibiotic resistance and cancer therapy. Its unique mechanism of action makes it a valuable tool for studying cellular processes related to gene expression and cell cycle regulation. -
Calcineurin Phosphatase Inhibitor
Dibefurin is a potent inhibitor of calcineurin phosphatase, a critical regulator of calcium-dependent signaling pathways. This fungal metabolite has demonstrated significant biological activity in various cellular processes, making it a valuable tool for studying immune response and neuronal signaling. Its application extends to research focused on autoimmune diseases and neurodegenerative disorders, where calcineurin activity plays a pivotal role. -
IMPase Inhibitor
L-671776 is a non-competitive inhibitor of inositol monophosphatase (IMPase), a critical enzyme in the phosphoinositide signaling pathway. This compound, derived from the fungal strain ATCC 20928B, exhibits significant potential for modulating inositol levels and can be utilized in studies investigating mood disorders, neurodegenerative diseases, and other conditions linked to inositol metabolism. Its application in biochemical research can help elucidate the role of IMPase in cellular signaling processes. -
PTP1B Inhibitor
Deoxyfunicone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating an IC50 value of 24.3 µM through direct active site binding. This secondary fungal metabolite exhibits notable anti-inflammatory properties, making it a valuable tool for research into metabolic regulation and the treatment of inflammatory diseases. Its mechanism of action positions it as a significant compound for studies focused on diabetes and obesity-related conditions. -
HIV Integrase Inhibitor
Equisetin is an N-methylserine-derived acyl tetramic acid that functions as a potent HIV integrase inhibitor. It specifically interferes with the activity of HIV-1 integrase and demonstrates notable inhibition of 11β-HSD1 and Dnp-stimulated ATPase, with an IC50 of approximately 8 nmol per mg of protein. Additionally, Equisetin exhibits significant antibacterial properties, anti-inflammatory effects, and potential benefits in managing lipid-associated disorders while also showcasing cytotoxic activity. This compound is valuable for research applications focused on HIV treatment and the exploration of antimicrobial and anti-inflammatory mechanisms. -
Antibacterial Peptide
Golotimod hydrochloride is an immunomodulating peptide that targets antibacterial pathways. This compound enhances the efficacy of antituberculosis therapy by promoting thymic and splenic cell proliferation and improving macrophage functionality. Additionally, Golotimod hydrochloride inhibits STAT3 signaling, thereby modulating the severity and duration of oral mucositis in animal models subjected to radiation or combined treatments. Furthermore, it shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2). -
Antibacterial Peptide
Golotimod TFA is an immunomodulating peptide primarily known for its antibacterial properties. This compound enhances the efficacy of antituberculosis therapy and promotes thymic and splenic cell proliferation while improving macrophage function. It inhibits STAT3 signaling, demonstrating potential in mitigating the duration and severity of oral mucositis in irradiated animal models. Additionally, Golotimod TFA shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2). -
Anti-inflammatory/antibacterial Agent
Plumericin is an anti-inflammatory and antibacterial agent that primarily targets key signaling pathways involved in inflammation and cellular stress response. It has been shown to reduce apoptosis, activate Nrf-2, and inhibit both NF-κB and AhR activation, while also blocking STAT3 signaling. Plumericin exhibits inhibitory effects on Mycobacterium tuberculosis growth, making it a valuable compound for studying chronic kidney disease, vascular diseases, inflammatory bowel diseases, peritonitis, and tuberculosis. -
HSV-1 Inhibitor
Gallic aldehyde, also known as 3,4,5-trihydroxybenzaldehyde, targets herpes simplex virus type 1 (HSV-1) through its potent antiviral properties. This phenolic aldehyde exhibits notable anti-HSV-1 activity while also functioning as an effective antioxidant. Additionally, gallic aldehyde inhibits the gelatinolytic activity and expression of matrix metalloproteinase-9 (MMP-9), as well as the activation of ERK1/2, p38, and JNK signaling pathways. Its antibacterial effects are further demonstrated against Oenococcus oeni VF, making it a valuable reagent for diverse biological research applications. -
SARS-CoV PLpro Inhibitor
4'-O-Methylbavachalcone is a prenylated flavonoid that acts as an inhibitor of the SARS-CoV papain-like protease (PLpro), displaying an IC50 value of 10.1 μM and a Ki of 4.6 μM. This compound has demonstrated the ability to inhibit poly (ADP-ribose) polymerase-mediated cell death and reduce cerebral infarct volume. Additionally, it modulates SUCNR1 activity and interferes with ERK1/2 signaling pathways, affecting cardiomyocyte hypertrophy. 4'-O-Methylbavachalcone is applicable in research focused on ischemic stroke, SARS-CoV, and cardiovascular diseases. -
Antibiotic
Tigecycline hydrochloride is a broad-spectrum glycylcycline antibiotic that primarily targets bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits significant antibacterial activity against a variety of gram-positive and gram-negative pathogens, including Escherichia coli and Acinetobacter baumannii, with mean inhibitory concentrations (MIC) of approximately 125 ng/mL for E. coli and MIC50 and MIC90 values of 1 and 2 mg/L for A. baumannii, respectively. Tigecycline hydrochloride is commonly used in research settings to investigate antibiotic resistance mechanisms and to study the efficacy of antimicrobial agents. -
Antibiotic
DCAP is a broad-spectrum antibiotic that targets the membranes of both Gram-positive and Gram-negative bacteria. It exhibits significant antibacterial activity by disrupting autophagic processes, specifically blocking the maturation of autophagolysosomes and interrupting autophagic flux. This compound is utilized in research applications focused on bacterial infections and autophagy regulation. -
Parasite Inhibitor
CpCDPK1/TgCDPK1-IN-1 is a potent dual inhibitor of CpCDPK1 and TgCDPK1, demonstrating IC50 values of 10 nM and 5.0 nM, respectively. In addition, it shows inhibitory activity against Abl and Src kinases with IC50 values of 75 nM and 65 nM. This compound is suitable for research applications related to toxoplasmosis, providing valuable insights into the therapeutic targeting of these pathways. -
Stable Isotope
Loratadine-d5 is a deuterium-labeled derivative of Loratadine, a selective inverse agonist of peripheral histamine H1 receptors. It has demonstrated an IC50 of over 32 μM and exhibits anti-Dengue virus (DENV) activity. Loratadine also inhibits the immunologic release of inflammatory mediators, making Loratadine-d5 a valuable reagent for research in pharmacology and immunology. -
Antifungal Agent
Moracin D is a flavonoid derived from Morus alba, known for its antifungal properties. This compound exhibits significant biological activity, including the induction of cell apoptosis, hypoglycemic effects, and antiadipogenic action. Moracin D is primarily utilized in research involving fungal infections and breast cancer, making it a valuable reagent in the investigation of therapeutic strategies. -
Antifungal Agent
Xanthochymol is an antifungal agent derived from Clusia rosea, primarily targeting fungal cells. This compound demonstrates the ability to induce apoptosis in fungi, making it a valuable tool for investigating fungal cell death mechanisms. It is applicable in research focused on antifungal therapies and the study of fungal pathogen responses to stress. -
Antibiotic
Ascochlorin is an isoprenoid antibiotic that primarily targets the STAT3 signaling cascade, leading to the suppression of tumor growth. It has demonstrated the ability to induce apoptosis in cancer cells while exhibiting anti-inflammatory properties. This compound is valuable for research applications focusing on cancer biology, inflammation, and the modulation of intracellular signaling pathways. -
Cation Ionophore
Calcimycin hemicalcium salt is a potent cation ionophore that primarily facilitates the transport of divalent cations such as calcium and magnesium across cellular membranes. This compound is known to induce Ca2+-dependent cell death by elevating intracellular calcium concentrations, making it valuable for research into apoptosis and autophagy mechanisms. Additionally, Calcimycin hemicalcium salt exhibits antibacterial activity against Gram-positive bacteria and some fungal species, while also inhibiting ATPase activity and uncoupling oxidative phosphorylation in mammalian cells. Its diverse biological effects make it a useful reagent for various biochemical and cellular studies. -
Antifungal Agent
Melittin free acid is a 26-amino-acid polypeptide and a potent activator of phospholipase A2 (PLA2) with significant antifungal activity. It demonstrates broad-spectrum antifungal efficacy, displaying minimum inhibitory concentration (MIC) values between 0.4-60 μM. Melittin free acid exerts its biological effects by promoting fungal cell apoptosis, inhibiting (1,3)-β-D-glucan synthase, and engaging in various other cellular pathways, making it a valuable reagent for research in antifungal mechanisms and therapeutic applications.
