Catalog No.
Product Name
Application
Product Information
Citations
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HBV Inhibitor
Isoscopoletin, also known as 6-Hydroxy-7-methoxycoumarin, primarily inhibits hepatitis B virus (HBV) replication. It demonstrates significant cytotoxic effects against human CCRF-CEM leukaemia cells and their multidrug-resistant subline, with IC50 values of 4.0 μM and 1.6 μM, respectively. Additionally, Isoscopoletin exhibits anti-inflammatory properties by modulating the MAPK/NF-κB/STAT/AKT signaling pathways, making it a valuable compound for research in virology and cancer biology. -
IL-6 Inhibitor
Koaburaside is an IL-6 inhibitor known for its cytoprotective and anti-inflammatory properties. This natural compound exhibits significant antioxidant activity, with an IC50 value of 9.0 μM in the DPPH free radical scavenging assay. Additionally, Koaburaside effectively reduces histamine release and downregulates the expression of pro-inflammatory cytokines IL-6 and TNF-α in human mast cells. It also demonstrates inhibitory effects on influenza A neuraminidase, highlighting its potential applications in inflammatory and viral research. -
Iron Chelator
Desferricoprogen is a hydrophobic fungal iron chelator that targets iron metabolism. It has been shown to reduce atherosclerotic plaque formation and inhibit lipid peroxidation in the aortic roots of ApoE−/− mice on an atherogenic diet. Additionally, Desferricoprogen effectively lowers levels of oxidized LDL (oxLDL) and inhibits the expression of oxLDL-induced genes such as HO-1, CD36, and TNF-α. Furthermore, it prevents TNF-α-induced endothelial cell activation and maintains endothelial monolayer integrity, making it a valuable tool for research on atherosclerosis. -
Anti-inflammatory Agent
Lucidone is an anti-inflammatory agent derived from the fruit of Lindera erythrocarpa Makino. It effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 mouse macrophages, while also reducing tumor necrosis factor-alpha (TNF-α) secretion and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, Lucidone prevents the translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and inhibits signaling pathways mediated by c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK). It also exhibits inhibitory activity against the Dengue virus (DENV), with an EC50 value of 25 μM. -
Antibiotic
Ceftiofur sodium is an antibiotic that acts as a cell wall synthesis inhibitor by targeting bacterial penicillin-binding proteins (PBPs). It exhibits bactericidal activity through the inhibition of peptidoglycan synthesis, resulting in bacterial cell lysis. Additionally, Ceftiofur sodium has anti-inflammatory properties by inhibiting the activation of NF-κB and MAPKs, which decreases the secretion of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6. This compound is applicable in research related to antibiotic resistance and inflammatory responses. -
EV71 Inhibitor
Mosloflavone is a flavonoid derived from Scutellaria baicalensis Georgi, exhibiting inhibitory activity against Enterovirus 71 (EV71). It targets the VP2 protein, preventing viral replication and inhibiting the synthesis of viral capsid proteins during the early stages of infection. Additionally, Mosloflavone demonstrates biocidal properties by inhibiting Pseudomonas aeruginosa virulence and biofilm formation, making it a valuable tool for research in virology and microbiology. -
Antibacterial Agent
Desfuroylceftiofur is an antibacterial agent and the predominant microbiologically active metabolite of ceftiofur, retaining an intact β-lactam ring. This compound exhibits in vitro activity against a range of Gram-negative and Gram-positive veterinary pathogens, including common equine pathogens. Desfuroylceftiofur is suitable for research applications focused on respiratory infections in veterinary medicine. -
HIV-1 Entry Inhibitor
Trilobatin is a natural sweetener extracted from Lithocarpus polystachyus Rehd, functioning primarily as an HIV-1 entry inhibitor by targeting the HIV-1 Gp41 envelope protein. It demonstrates neuroprotective effects and acts as a selective SGLT1/2 inhibitor, promoting the proliferation of human hepatoblastoma cells. Trilobatin is valuable for research involving HIV-1 entry mechanisms and potential therapeutic applications in hepatoblastoma and neuroprotection studies. -
Bacterial Inhibitor
Lysozyme, also known as Muramidase, is a conserved antimicrobial protein that targets bacterial cell wall peptidoglycan (PG). It exerts a bactericidal effect by hydrolyzing PG, thereby limiting bacterial growth on mucosal surfaces and controlling potential pathogens while preventing dysbiosis through microbiota regulation. Additionally, extracellular lysozyme degrades polymeric PG into soluble fragments, activating NOD receptors in mucosal epithelial cells and stimulating the secretion of chemokines and activating factors by neutrophils and macrophages. This makes lysozyme a valuable reagent for studies involving antimicrobial activity, immune response, and microbiome research. -
Bacterial Inhibitor
Ciclopirox olamine is a synthetic antifungal agent primarily targeting various fungal pathogens. It exhibits a broad spectrum of activity against dermatophytes, yeasts, molds, and multiple Gram-positive and Gram-negative bacteria. In addition to its antibacterial properties, Ciclopirox olamine has demonstrated anticancer and anti-inflammatory effects, making it a valuable reagent for research in superficial mycoses, cancer biology, and inflammation studies. -
Parasite Inhibitor
Dihydroartemisinic acid, a biosynthetic precursor to the antimalarial compound Artemisinin, functions primarily as a parasite inhibitor. This compound demonstrates potent activity against malaria-causing Plasmodium species, making it valuable for research in malaria treatment and drug development. Its role in synthesizing Artemisinin positions it as an important reagent for studies focusing on antimalarial therapies. -
Anti-HIV Agent
Oleanonic acid, a triterpene, primarily targets anti-HIV activity. It exhibits notable anti-inflammatory properties and can ameliorate conditions associated with oxidative stress, autophagy dysfunction, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress, particularly induced by Amyloid-β in vitro. Additionally, oleanonic acid has been demonstrated to reduce myocardial hypertrophy in rat models in vivo, highlighting its potential for therapeutic applications in cardiovascular and neurodegenerative research. -
Antifungal Agent
Fluconazole is a triazole antifungal agent that primarily targets fungal infections by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. It exhibits potent activity against a wide spectrum of fungi, particularly Candida albicans and Candida kefyr, with IC99 values ranging from 0.20 μg/mL to 0.39 μg/mL. Fluconazole is widely utilized in research to study fungal pathogenesis and develop therapeutic strategies against fungal infections. -
Quinolone Antibiotic
Lomefloxacin hydrochloride is a difluoroquinolone antibiotic that primarily targets bacterial topoisomerase II, inhibiting DNA supercoiling and replication. It exhibits broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria and induces reactive oxygen species (ROS) production, leading to apoptosis. Additionally, Lomefloxacin hydrochloride demonstrates anticancer effects, particularly against melanoma, making it a valuable reagent for studying systemic bacterial infections and skin malignancies. -
Antifungal Agent
Miconazole is an imidazole antifungal agent that acts through the inhibition of ergosterol synthesis, disrupting fungal cell membrane integrity. In addition to its antifungal properties, Miconazole exhibits antibacterial effects, making it a versatile compound in microbiological studies. This reagent is commonly utilized in research focusing on antifungal therapies and mechanisms of microbial resistance. -
Antifungal Agent
Miconazole nitrate is an imidazole antifungal agent that exhibits its primary mechanism through the inhibition of ergosterol synthesis, leading to compromised fungal membrane integrity. This compound demonstrates significant antifungal activity against a broad spectrum of fungi, making it valuable for research in antifungal drug development and therapeutic applications. Additionally, Miconazole nitrate possesses antibacterial properties, contributing to its utility in studies related to infections and microbial resistance. -
Antibiotic
Novobiocin sodium is a potent antibiotic that primarily targets DNA gyrase, exhibiting significant inhibitory action in various bacterial strains. Additionally, it acts as an antagonist of heat shock protein 90 (Hsp90), expanding its potential applicability in therapeutic research. Novobiocin sodium is particularly valuable for studies on beta-lactam-resistant pneumococcal infections and demonstrates anti-orthopoxvirus activity, highlighting its relevance in infectious disease research. -
Bacterial Inhibitor
Roxithromycin is a semi-synthetic macrolide antibiotic that exerts its antibacterial effects by inhibiting protein biosynthesis at the elongation step through binding to the 50S subunit of the bacterial ribosome. This compound demonstrates broad biological activity, including antimicrobial, antiproliferative, and anti-inflammatory properties. Additionally, Roxithromycin has been shown to inhibit tumor vasculature and alleviate lung injury, making it a valuable reagent for research applications in infectious disease, cancer therapy, and respiratory health. -
Nucleoside Reverse Transcriptase Inhibitor
Stavudine is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that selectively targets HIV-1 and HIV-2. In addition to its antiviral properties, Stavudine inhibits mitochondrial DNA replication and has been shown to reduce NLRP3 inflammasome activation while modulating Amyloid-β autophagy. Furthermore, Stavudine is associated with the induction of apoptosis, making it a valuable tool for research in HIV treatment and cellular apoptosis mechanisms. -
Antimicrobial Agent
Terbinafine is a potent antimicrobial agent that primarily acts as a non-competitive inhibitor of squalene epoxidase, exhibiting a Ki of 30 nM against Candida species. This compound demonstrates significant antifungal activity and also shows antibacterial effects against select Gram-positive and Gram-negative bacteria. Additionally, Terbinafine features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for versatile chemical applications in research. -
Antifungal Agent
Oxiconazole nitrate is a broad-spectrum antifungal agent targeting various fungal pathogens, including Candida, Aspergillus, and Trichophyton. In addition to its antifungal properties, it acts as a potent activator of CYP3A4 transactivation, with the potential for competitive antagonism by Rifampicin. Furthermore, Oxiconazole nitrate exhibits inhibitory effects against colorectal cancer through mechanisms involving peroxiredoxin-2 (PRDX2)-mediated autophagy arrest, making it valuable for research in both antifungal therapy and cancer biology. -
Squalene Epoxidase Inhibitor
Liranaftate is a potent squalene epoxidase inhibitor exhibiting anti-fungal properties. It is primarily utilized in research focusing on dermatophyte infections. Additionally, Liranaftate has been shown to suppress the fungal element-mediated production of interleukin-8 (IL-8) and modulate inflammatory responses, making it valuable for studies involving inflammatory pathways in fungal infections. -
Antibiotic
Bifonazole is an imidazole antifungal agent that primarily targets fungal cell membranes. It exhibits broad-spectrum antibacterial and antifungal activity, making it effective against various dermatophytes and yeast infections. Bifonazole is utilized in research settings to study antifungal mechanisms and evaluate new therapeutic strategies for fungal infections. -
Antifungal Agent
Gartanin is a natural xanthone derived from mangosteen, primarily functioning as an antifungal agent. It exhibits significant antioxidant and anti-inflammatory properties, alongside neuroprotective and antineoplastic effects. Gartanin has been shown to induce cell cycle arrest and autophagy, while also inhibiting migration in human glioma cells, making it a valuable compound for research in cancer and fungal pathologies. -
Fungal Inhibitor
Pseudolaric Acid C is a bioactive diterpenoid derived from the root bark of Pseudolarix amabilis, primarily acting as a fungal inhibitor. It exhibits significant antifungal activity, making it a valuable tool for research focused on fungal pathogenesis and the development of antifungal therapies. Its ability to disrupt fungal growth positions it as an important compound in the study of mycology and related fields. -
Fungal Inhibitor
5-Hydroxymethylfurfural is a furan derivative that serves as a potent fungal inhibitor. It exhibits anti-yeast activity by suppressing growth and fermentation under stress conditions, making it valuable for studies related to microbial resistance and fermentation processes. This compound is utilized in research focused on food preservation and biotechnological applications. -
Antibacterial/Anticancer Agent
Usnic acid is a secondary metabolite derived from lichens, exhibiting significant antibacterial and anticancer properties. It functions primarily by inhibiting DNA and RNA synthesis, leading to cell cycle arrest and apoptosis in various cancer cell lines. Additionally, usnic acid suppresses RANKL-mediated osteoclast formation and function through downregulation of NFATc1. Its antioxidant and anti-inflammatory effects are attributed to the inhibition of lipid peroxidation and myeloperoxidase activity, making it a valuable reagent for diverse biological research applications. -
Bactericidal Agent
Terpinen-4-ol, a naturally occurring monoterpene, acts primarily as a bactericidal agent. This compound exhibits significant antifungal, anti-inflammatory, and antitumor activities, making it a valuable tool for diverse research applications, especially in the study of microbial resistance and inflammation. Its multiple biological effects also support investigations into potential therapeutic uses in various diseases. -
Bicyclic Sesquiterpene
Caryophyllene oxide is a bicyclic sesquiterpene known for its anticancer properties, particularly its ability to induce apoptosis in PC-3 prostate cancer cells. This compound also exhibits significant analgesic and anti-inflammatory activities, making it valuable for pain management research. Additionally, caryophyllene oxide demonstrates a range of biological activities, including insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic effects, supporting its utility in various pharmacological studies and natural product research. -
Anti-Fungal Agent
Hypocrellin B is a photosensitizer with significant apoptotic properties, primarily used in photodynamic therapy for cancer treatment. Isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, it exhibits both antimicrobial and antileishmanial activities. This compound is valuable in research exploring its efficacy against various fungal infections and its potential therapeutic applications in oncology. -
Antifungal Agent
4-Methylcinnamic acid is a cinnamic acid derivative primarily known for its antifungal properties. This compound demonstrates the capability to enhance the efficacy of traditional antifungal agents by lowering their minimum inhibitory concentrations, particularly in the presence of glutathione reductase mutants. Its mechanism includes disrupting fungal cell walls, making it a promising candidate for research into combating drug-resistant fungi. 4-Methylcinnamic acid shows potential applications in the development of more effective antifungal therapies. -
Antifungal Agent
Vincetoxicoside B is an antifungal agent that exhibits potent activity against various fungal pathogens. This compound can be utilized in research focused on fungal infections and the development of new therapeutic strategies. Its mechanism of action and efficacy make it a valuable tool in the study of antifungal mechanisms and resistance. -
Fungal Inhibitor
Hecogenin is a steroid saponin derived from Agave sisalana, known for its selective inhibition of human UDP-glucuronosyltransferases. It exhibits a diverse range of biological activities, particularly as a potent antifungal agent, while also demonstrating anti-inflammatory and gastroprotective properties. Hecogenin is of interest in pharmacological research for its potential therapeutic applications in treating fungal infections and inflammatory conditions. -
Antioxidant/Antibacterial/Anticancer Agent
Carvacrol is a monoterpenic phenol that functions as an antioxidant, antibacterial, and anticancer agent. It has demonstrated the ability to cause cell cycle arrest in the G0/G1 phase, downregulate Notch-1 and Jagged-1, and induce apoptosis in cancerous cells. Carvacrol is frequently utilized in research to investigate its therapeutic effects in various biological systems, alongside its applications in food preservation and cosmetic formulations due to its flavoring and fragrance properties. -
Cytochrome P450 1A1 Inactivator
Rhapontigenin is a potent and selective inactivator of cytochrome P450 1A1, demonstrating an IC50 of 400 nM. This natural analog of resveratrol exhibits significant anticancer, antioxidant, antifungal, and antibacterial properties. Due to its 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively, Rhapontigenin is a valuable tool for research focused on cancer biology and drug metabolism. -
Bacterial Inhibitor
Benzoic acid is an aromatic carboxylic acid that functions as a bacterial inhibitor. It demonstrates significant antimicrobial activity by inhibiting the growth of bacteria and fungi, making it an effective preservative. Benzoic acid is widely utilized in food, beverages, cosmetics, and various research applications to study microbial growth inhibition and preservation techniques. -
Antifungal Agent
Xanthoxylin, an antifungal agent derived from Zanthoxylum simulans, exhibits notable antifungal and antioxidant properties. It demonstrates minimum inhibitory concentrations (MIC) of 50 µg/mL against Toxoplasma neonatorum and 75 µg/mL against Aspergillus fumigatus. This compound is valuable for investigating antifungal therapies and exploring potential applications in the context of anti-epileptic diseases. -
Antibacterial/Antifungal agent
Dehydroacetic acid is a pyrone derivative known for its antibacterial and antifungal properties. This compound exhibits significant phytotoxic activity, making it a valuable agent in various applications such as preservation in cosmetics, food, and beverages. Additionally, dehydroacetic acid serves as a precursor in the synthesis of various heterocycles and cycloaddition products, providing utility in chemical research and development. -
Antibiotic
Phenothiazine is an antibiotic that exhibits broad-spectrum biological activity, including insecticidal, fungicidal, antibacterial, and anthelmintic effects. Additionally, it is instrumental in research related to neurological diseases, offering insights into potential therapeutic mechanisms. This compound serves as a valuable tool for scientists studying microbial resistance and the treatment of parasitic infections. -
Antifungal Agent
Sertaconazole nitrate is a broad-spectrum topical antifungal agent that primarily targets fungal infections. In addition to its antifungal properties, it exhibits anti-inflammatory activity through the activation of the p38-COX-2-PGE2 pathway. Sertaconazole nitrate also acts as a microtubule inhibitor, demonstrating antiproliferative effects, as well as the ability to induce apoptosis and autophagy. Furthermore, it can inhibit cell migration, making it valuable for various research applications in mycology and cellular biology. -
Antifungal Agent
Sulconazole mononitrate is an imidazole derivative that acts as a broad-spectrum antifungal agent. It exhibits significant efficacy against various fungal infections, making it useful for research related to dermatomycoses, pityriasis versicolor, and cutaneous candidiasis. This compound can facilitate studies aimed at understanding the mechanisms of fungal resistance and the development of effective treatment options. -
Antibiotic
Sulfacetamide sodium is a sulfonamide antibiotic targeting bacterial infections, primarily utilized in ocular research. It exhibits both antibacterial and antifungal activity, making it an important reagent for studying and treating various infections. Applications include investigation of microbial resistance and the efficacy of topical treatments against ocular pathogens. -
Bacterial Inhibitor
Tilmicosin is a macrolide antibiotic and calcium channel antagonist that targets the bacterial ribosome's 50S subunit, effectively inhibiting protein synthesis. It possesses significant antimicrobial activity and is primarily utilized in treating respiratory diseases in livestock, including cattle, sheep, and pigs. Additionally, Tilmicosin exhibits immunomodulatory and anti-inflammatory properties, making it a valuable reagent in veterinary medicine research. -
Antimicrobial Agent
Mafenide Acetate is a potent sulfonamide antimicrobial agent primarily targeting bacterial infections. It exhibits significant antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, as well as antifungal activity against filamentous fungi, including Lichtheimia and Aspergillus flavus. This compound is valuable in research applications related to skin grafts on burn wounds, post-traumatic invasive fungal infections, and the treatment of bacterially contaminated wounds. -
Antifungal Agent
10-Undecenoic acid zinc salt is an antifungal agent that targets various fungal pathogens. It demonstrates biological activity by inhibiting Aβ oligomerization, scavenging reactive oxygen species (ROS), and inhibiting μ-calpain activity, contributing to its neuroprotective properties. Additionally, this compound has anticancer effects against multiple tumor types and effectively inhibits biofilm formation by C. albicans as well as infections from MRSA. Furthermore, 10-Undecenoic acid zinc salt disrupts quorum sensing signals in Bacillus subtilis and Pseudomonas aeruginosa, highlighting its broad-spectrum antimicrobial potential. -
Antibiotic
Sulfacetamide sodium monohydrate is a sulfonamide antibiotic primarily targeting bacterial infections. It exhibits both antifungal and antibacterial activities, making it valuable for studying ocular infections. This reagent is useful in research applications that explore mechanisms of infection and treatment efficacy in ophthalmology. -
Antifungal/Exosome Inhibitor
Neticonazole hydrochloride is an imidazole derivative that acts as a potent antifungal agent through the inhibition of fungal sterol synthesis. In addition to its antifungal properties, it has shown promising anti-cancer effects, primarily through the modulation of exosome release and related pathways. This compound is suitable for research applications aimed at exploring antifungal therapies and investigating potential anti-cancer mechanisms. -
Fungal Inhibitor
Piroctone olamine is a pyridine derivative that acts as a potent fungal inhibitor by disrupting fungal cell membrane integrity. It exhibits fungicidal activity effective against a variety of dermatophytes and yeast, making it valuable for research in antifungal treatment and dermatological applications. Its mechanism of action supports investigations into fungal pathogenesis and the development of antifungal therapies. -
Antifungal Agent
Econazole is an orally active imidazole antifungal agent that primarily targets the cytochrome P-450 enzyme system. It demonstrates significant antifungal activity against various fungi and some Gram-positive bacteria, while lacking efficacy against Gram-negative bacteria. Additionally, econazole is known to inhibit prostaglandin synthesis and may induce hepatotoxicity, making it valuable in the study of antifungal resistance and the mechanisms of liver injury. -
Antibacterial Agent
Tilmicosin phosphate is a macrolide antibiotic that primarily targets the 50S subunit of bacterial ribosomes, effectively inhibiting protein synthesis. This compound exhibits antibacterial properties, making it particularly useful for treating respiratory infections in livestock, including cattle, sheep, and pigs. Additionally, Tilmicosin phosphate demonstrates immunomodulatory and anti-inflammatory activities that may enhance its therapeutic efficacy in veterinary applications.
