Catalog No.
Product Name
Application
Product Information
Citations
- Delmopinol is a surface-active cationic compound that functions as an anti-plaque and anti-gingivitis agent. It interacts with the acquired pellicle—a thin salivary film composed of proteins and glycoproteins that coats the teeth and gums—and forms a protective barrier over oral surfaces. This barrier inhibits microbial adhesion and biofilm formation, thereby preventing plaque accumulation and gingival inflammation. Although Delmopinol does not possess direct bactericidal activity, its ability to interfere with bacterial colonization makes it effective in maintaining oral hygiene. It has been approved by the U.S. FDA under the trade name **Decapinol** for the treatment of gingivitis and the prevention of periodontitis.
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actin polymerization inhibitor
Cytochalasin D (also known as Zygosporin A) is a cell-permeable fungal metabolite and a potent inhibitor of actin polymerization. It binds to G-actin, thereby disrupting the G-actin–cofilin interaction and preventing cofilin association with F-actin. Through this mechanism, Cytochalasin D reduces both actin polymerization and depolymerization rates in living cells, leading to profound effects on cytoskeletal organization and cell morphology. In addition, Cytochalasin D suppresses exosome release, consequently decreasing survivin levels within the tumor microenvironment. It also promotes phosphorylation and cytoplasmic retention of YAP, implicating it in the regulation of mechanotransduction and tumor cell signaling. -
Sulfaquinoxaline is a veterinary antimicrobial agent effective against a broad spectrum of Gram-negative and Gram-positive bacteria. It is commonly used for the prevention and treatment of coccidiosis and bacterial infections in livestock and poultry.
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NS3-NS4B interaction inhibitor
(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor that targets the NS3–NS4B protein interaction. It demonstrates nanomolar to picomolar antiviral activity across a panel of 21 clinical dengue virus isolates. With a favorable pharmacokinetic profile, (+)-JNJ-A07 exhibits exceptional efficacy in mouse models of dengue virus infection, making it a strong candidate for antiviral research and therapeutic development. -
Hsp90/HSV inhibitor
AT-533 is a potent inhibitor of heat shock protein 90 (Hsp90) and herpes simplex virus (HSV), exhibiting strong antitumor and antiviral activities. It suppresses tumor growth and angiogenesis by disrupting the HIF-1α/VEGF/VEGFR-2 signaling axis, a critical pathway in tumor vascularization and progression. Additionally, AT-533 inhibits key downstream signaling cascades, including Akt/mTOR/p70S6K, ERK1/2, and FAK pathways. In endothelial cells, specifically human umbilical vein endothelial cells (HUVECs), AT-533 effectively inhibits tube formation, cell migration, and invasion, highlighting its anti-angiogenic properties. These combined effects position AT-533 as a promising candidate for cancer therapy and angiogenesis-related disease research. -
HIV-1 protease/PTP1B inhibitor
Isosinensetin is a bioactive flavonoid compound with diverse pharmacological properties. It acts as a dual inhibitor of HIV-1 protease and protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 2.61 µM and a Kᵢ of 0.92 µM for PTP1B, indicating its potential in antiviral and metabolic disease research. Additionally, isosinensetin inhibits P-glycoprotein (P-gp) activity in MDR1-MDCKII cells, suggesting its utility in overcoming multidrug resistance. Isosinensetin exhibits multiple therapeutic effects, including anti-tumor, anti-viral, anti-inflammatory, and antioxidant activities. These properties support its application in the research of various conditions such as cancer, chronic inflammation, osteoporosis, diabetes, and infectious diseases. -
glutamine amidotransferase inhibitor
Azaserine (CI-337) is a glutamine analog and competitive inhibitor of glutamine amidotransferase, an enzyme involved in nucleotide biosynthesis. It exhibits both antibiotic and antitumor properties by disrupting glutamine-dependent metabolic processes essential for cell proliferation. Azaserine demonstrates antibacterial activity and has shown antitumor effects in various cancer models. However, it has also been reported to possess tumorigenic potential under certain conditions, warranting cautious evaluation. -
Innate defense regulator
Dusquetide (SGX-942, SGX94) is a synthetic 5-amino acid peptide and innate defense regulator (IDR) with immunomodulatory, anti-inflammatory, anti-infective, and anti-mucositis properties. Upon intravenous administration, it binds to the ZZ domain of sequestosome-1 (p62), activating key signaling pathways such as MAPK p38 and C/EBP involved in innate immune regulation. Dusquetide is a promising agent for modulating immune responses in various inflammatory and infectious conditions. -
Glucosinolate
Sinigrin, a glucosinolate primarily found in cruciferous vegetables, exhibits significant biological activities including anti-cancer, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, along with the inhibition of fat synthesis. This compound is of particular interest in cancer research, as well as studies focused on inflammatory and metabolic diseases. Its diverse therapeutic potential makes it a valuable reagent for exploring various biological pathways. -
Antibacterial Agent
Deoxyshikonin is an antibacterial agent that exhibits significant activity against methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae, with a minimum inhibitory concentration (MIC) of 17 μg/mL. It enhances the expression of VEGF-C and VEGF-A mRNA in human microvascular endothelial cells, promotes the interaction of HIF-1α and HIF-1β subunits, and binds to specific DNA sequences associated with HIF. Additionally, Deoxyshikonin demonstrates proangiogenic and antitumor effects by inhibiting colorectal cancer via the PI3K/Akt/mTOR signaling pathway, making it valuable for both antibacterial and cancer research applications. -
Antibiotic
Berberine hemisulfate is an alkaloid with antibiotic properties derived from the traditional Chinese herbal medicine Huanglian. It demonstrates significant antimicrobial activity and possesses anti-inflammatory, antitumor, cardiovascular protective, and neuroprotective effects. This compound is valuable for research applications exploring infections, immune response modulation, and potential therapeutic avenues for various diseases. -
HIV Reverse Transcriptase Inhibitor
β-Rubromycin is a selective inhibitor of HIV-1 reverse transcriptase, exhibiting a Ki of 0.27 μM. Additionally, it demonstrates potent telomerase inhibition with an IC50 of 3 μM. β-Rubromycin effectively inhibits the proliferation of K-562 and HeLa cell lines, showing IC50 values of 19.5 µM and 22.7 µM, respectively, making it a valuable tool for research in HIV and telomerase-related studies. -
Antibacterial Agent
ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor of thyroxine binding globulin (TBG), exhibiting a Ki value of 2.09×10^6 M^-1. This compound is utilized in radioimmunoassays to enhance detection sensitivity by displacing bound triiodothyronine (T3) and facilitating its recognition by antibodies. Additionally, ANS serves as a fluorescent probe, selectively binding to hydrophobic regions of proteins, particularly membrane proteins, allowing for real-time monitoring of protein conformational dynamics through fluorescence changes. Its applications extend to biochemical research and the development of antibacterial materials. -
SIRT Inhibitor
Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity. -
Antihelminthic Agent
Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells. -
Antibiotic
Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases. -
HIV Protease Inhibitor
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives. -
Antibiotic
Erythromycin is a macrolide antibiotic that targets bacterial 50S ribosomal subunits, effectively inhibiting RNA-dependent protein synthesis by obstructing transpeptidation and translocation reactions. This compound demonstrates a broad spectrum of antimicrobial activity against various bacteria, making it valuable in microbiological research. Additionally, erythromycin has been shown to possess antitumor and neuroprotective properties, contributing to its usefulness in diverse areas of biomedical research. -
Apoptosis Inducer
Sanguinarine chloride is a benzophenanthridine alkaloid that functions as an apoptosis inducer primarily through the generation of reactive oxygen species (ROS). This compound is known to activate key signaling pathways, specifically JNK and NF-κB, facilitating programmed cell death. Sanguinarine chloride is widely utilized in cancer research and studies investigating apoptotic mechanisms. -
Antibiotic
Tetracycline is a broad-spectrum antibiotic that targets bacterial protein synthesis by binding to the 30S ribosomal subunit, inhibiting translation. It demonstrates activity against a diverse array of microorganisms, including gram-positive and gram-negative bacteria, as well as chlamydiae, mycoplasmas, and rickettsiae. This compound is widely utilized in research related to bacterial infections and antibiotic resistance mechanisms. -
Bacterial Inhibitor
Cefamandole sodium is a second-generation broad-spectrum cephalosporin antibiotic that primarily targets bacterial cell wall synthesis. It exhibits significant antibacterial activity against a variety of gram-positive and gram-negative bacteria, making it valuable for research into antimicrobial resistance and the mechanisms of bacterial infections. This compound is commonly utilized in studies assessing the efficacy of antibiotic treatments and in exploring bacterial susceptibility profiles. -
Fluorescent Dye
Acridine Orange base is a cell-permeable fluorescent dye primarily utilized for staining nucleic acids in various organisms, including bacteria, parasites, and viruses. This dye exhibits distinct fluorescence characteristics; it emits green light when bound to double-stranded DNA (Ex=488 nm, Em=520-524 nm) and red light when associated with single-stranded DNA or RNA (Ex=457 nm, Em=630-644 nm). Acridine Orange base is particularly valuable in fluorescence microscopy for distinguishing human cells under acidic conditions (pH=3.5) and is widely employed in cell cycle assays. -
Photobase Reagent
Malachite Green Carbinol Base acts as a photobase reagent, capable of releasing hydroxide ions (OH-) upon ultraviolet light irradiation. This reaction facilitates a progressive shift in pH levels, allowing for precise pH regulation in experimental settings. When exposed to high-intensity UV light (500 W, 50 W/cm), the solution transitions rapidly from colorless to deep green, which can be utilized for applications in photochemistry and environmental monitoring. -
Antiviral Agent
Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research. -
Broad-spectrum Antiviral Agent
Moroxydine (ABOB) hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels. -
Bacterial Inhibitor
Ceftiofur is a cell wall synthesis inhibitor targeting bacterial penicillin-binding proteins (PBPs). It demonstrates bactericidal activity by interfering with the peptidoglycan synthesis in bacterial cell walls, resulting in cell lysis. Additionally, Ceftiofur exhibits anti-inflammatory properties by inhibiting the activation of NF-κB and MAPKs, which decreases the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. This makes Ceftiofur a valuable reagent in research investigating bacterial infections and inflammation processes. -
Antiviral Agent
Amantadine (1-Adamantanamine) primarily functions as an antiviral agent targeting influenza A viruses. This compound inhibits ion channels, including M2 and NMDA, and demonstrates activity against Coronavirus ion channels. In addition to its antiviral properties, Amantadine has shown potential as an anti-orthopoxvirus agent and exhibits anticancer activity. Its applications extend to studies related to Parkinson's disease, postoperative cognitive dysfunction (POCD), and COVID-19 research. -
Fungicide
Pyraclostrobin is a strobilurin fungicide that functions by inhibiting mitochondrial respiration in fungi. It exhibits broad-spectrum antifungal activity, effectively controlling various crop diseases. Additionally, Pyraclostrobin has been shown to induce oxidative DNA damage and activate AMPK/mTOR signaling pathways, leading to mitochondrial dysfunction and autophagy. Its applications extend to agricultural settings for the management of fungal pathogens. -
Anti-inflammatory/anti-cancer/anti-viral/anti-tuberculosis Agent
4-Methoxycinnamic acid ethyl ester is a bioactive natural compound that functions primarily as an anti-inflammatory, anti-cancer, anti-viral, and anti-tuberculosis agent. It demonstrates potent anti-inflammatory activity by inhibiting cyclooxygenases (COX-1 and COX-2) and NF-κB, resulting in reduced cytokine production. Additionally, 4-Methoxycinnamic acid ethyl ester effectively inhibits tumor cell proliferation, migration, and angiogenesis through the downregulation of VEGF expression. It also exhibits significant antiviral properties against dengue virus and antimicrobial activity against Mycobacterium tuberculosis, along with notable analgesic effects in preclinical models. -
Short-chain Fatty Acid
Magnesium acetate tetrahydrate acts primarily as a short-chain fatty acid (SCFA). It is known to activate AMP-activated protein kinase (AMPK) and increase reactive oxygen species (ROS) levels, leading to the cleavage of caspase 9 and the modulation of peroxisome proliferator-activated receptor alpha (PPARα). Additionally, it downregulates the expression of sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate response element-binding protein (ChREBP), and demonstrates antifungal activity against Saccharomyces cerevisiae. Magnesium acetate tetrahydrate has shown promising anticancer effects in gastric cancer and may regulate energy metabolism while exhibiting potential therapeutic effects in ulcerative colitis and hepatic steatosis. -
Antibiotic
Acetoxycycloheximide is an antibiotic with potent antitumor properties, primarily functioning as a protein synthesis inhibitor. It effectively induces procaspase-3 activation, leading to apoptosis through the release of cytochrome c from mitochondria via the JNK signaling pathway. Additionally, acetoxycycloheximide downregulates cell surface TNF-R1 by activating the ERK and p38 MAPK pathways, thereby inhibiting TNF-α-mediated NF-κB signaling. This reagent is valuable for research related to inflammatory and immune diseases as well as cancer. -
Broad-spectrum Antiviral Agent
Moroxydine is a broad-spectrum antiviral agent targeting both DNA and RNA viruses, including influenza, herpes simplex, varicella zoster, and hepatitis C. It demonstrates significant antiviral efficacy while exhibiting low cytotoxicity, particularly against dsRNA viruses such as grass carp reovirus and large DNA viruses like giant salamander iridovirus. Moroxydine effectively inhibits cytopathic effects induced by GCRV and prevents the formation of nucleocapsids in renal cells, maintaining their normal morphology. Additionally, it significantly reduces apoptosis and modulates apoptosis-related proteins, including down-regulation of Bcl-2 and inhibition of caspase 3 activity. -
Bacterial Quorum-sensing Signaling Molecule
N-3-oxo-dodecanoyl-L-homoserine lactone is a bacterial quorum-sensing signaling molecule primarily associated with Pseudomonas aeruginosa and Burkholderia cepacia complex. This compound plays a critical role in bacterial communication, regulating gene expression in response to changes in cell density. Additionally, N-3-oxo-dodecanoyl-L-homoserine lactone has been shown to induce interleukin-8 (IL-8) production in human bronchial epithelial cells, making it valuable for research in host-pathogen interactions and inflammatory responses. -
Large Cyclic Mucor Toxin.
Satratoxin G is a large cyclic mucor toxin that primarily induces apoptosis through the activation of caspases. This compound exhibits potent biological activity, making it a valuable tool for studying apoptosis and cell signaling pathways. Satratoxin G is commonly utilized in research concerning fungal toxins and their effects on mammalian cells, providing insights into potential therapeutic interventions for toxin-related diseases. -
Microbial Metabolite
Oosporein is a microbial metabolite characterized as a red crystalline toxin produced by various fungi. It demonstrates significant biological activity by inhibiting insect immunity, thereby promoting fungal reproduction within host organisms. Additionally, Oosporein exhibits antibacterial, antiviral (specifically against herpes simplex virus), and insecticidal properties. Its effects on plant growth inhibition and its ability to induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage make it a valuable compound for research in multiple fields, including mycology, agriculture, and oncology. -
Influenza Virus Inhibitor
Dehydroandrographolide succinate acts as a potent inhibitor of the influenza virus. Extracted from the medicinal plant Andrographis paniculata, it exhibits immunostimulatory, anti-infective, and anti-inflammatory properties, making it valuable for research into viral pneumonia and upper respiratory tract infections. Additionally, it demonstrates antithrombotic effects by significantly reducing platelet aggregation, as evidenced by a calculated ED50 of 386.9 mg/kg. The compound also mitigates muscle atrophy through the Akt/GSK3β and MuRF-1 signaling pathways. -
Glucosinolate
Sinigrin hydrate is an allyl-glucosinolate known for its diverse biological activities, primarily targeting glucosinolate pathways. This compound exhibits anti-cancer, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, as well as the ability to inhibit fat synthesis. Sinigrin hydrate is valuable for research into tumor biology, inflammatory processes, and metabolic disorders. -
Antibiotic
Chrysomycin A is an antibiotic derived from the Streptomyces genus. It demonstrates significant antitumor properties, alongside effective activity against Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus (MRSA). In glioblastoma research, Chrysomycin A has been shown to inhibit cancer cell proliferation, migration, and invasion by targeting the Akt/GSK-3β/β-catenin signaling pathway, making it a valuable tool for cancer studies and antibiotic research. -
Furofuran Type Lignan
(+)-Medioresinol is a furofuran-type lignan that exhibits notable antifungal and antibacterial activities. It enhances the efficacy of antibiotics through its antimicrobial and antibiofilm properties and promotes intracellular reactive oxygen species (ROS) accumulation, leading to mitochondrial-mediated apoptosis in Candida albicans. Additionally, (+)-Medioresinol inhibits LPS-stimulated IL-12p40 production and acts as a PGC-1α activator, providing protection against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. This compound is valuable for research into fungal and bacterial infections, inflammatory responses, and ischemic stroke mechanisms. -
GPI/NS2B-NS3/CK1ε Inhibitor
Rhodiolin is a flavonoid that acts as a GPI (glucose 6-phosphate isomerase) and NS2B-NS3 protease inhibitor, with significant implications for cancer and viral research. It demonstrates the ability to inhibit glycolysis in papillary thyroid cancer, leading to suppressed PI3K/AKT/mTOR signaling and induced apoptosis. Additionally, Rhodiolin disrupts dengue viral replication through its action on the NS2B-NS3 protease. With its potential to inhibit CK1ε kinase, it serves as a valuable candidate for developing anticancer strategies and investigating anti-tumor and antiviral mechanisms. -
Fungicide
Triadimefon is an orally active fungicide targeting various fungal species. It has been shown to significantly reduce the phosphorylation of AKT1 and ERK1/2, while increasing levels of phosphorylated AMPK without affecting total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis impacting testosterone synthesis, and affects fetal adrenal development in rodent models. Additionally, it induces metabolic alterations in hepatocytes and impairs spatial learning and memory. -
Bacterial Inhibitor
Vasicine, a quinazoline alkaloid derived from Justicia adhatoda, primarily targets bacterial strains as an inhibitor. This compound is known to activate the PI3K/Akt signaling pathway and demonstrates significant antioxidant and anti-inflammatory activities. Its unique biological profile makes Vasicine valuable for research in microbial resistance and inflammation-related studies. -
Bacterial Inhibitor
Vasicine hydrochloride, a quinazoline alkaloid derived from Justicia adhatoda, acts primarily as a bacterial inhibitor. It activates the PI3K/Akt signaling pathway and demonstrates significant antioxidant and anti-inflammatory properties. This compound is valuable for research involving antimicrobial activity and cellular signaling pathways, making it a useful tool for studies in infectious disease and inflammation. -
Antibacterial Agent
Canthin-6-one is an indole alkaloid that serves as an effective antibacterial agent. Its primary mechanism involves the inhibition of bacterial growth, making it valuable for research in antimicrobial applications. Additionally, Canthin-6-one exhibits anti-inflammatory properties, suggesting potential in studies related to inflammation. -
Anthocyanin Compound
Cyanidin 3-sambubioside chloride is an anthocyanin compound noted for its ability to inhibit nitric oxide and angiotensin-converting enzyme (ACE) activity. It demonstrates significant antiviral properties, specifically inhibiting influenza neuraminidase with an IC50 of 72 μM and serves as a potent H274Y mutation inhibitor. Additionally, this compound exhibits antioxidant and anti-angiogenic activities, making it suitable for various biological and pharmaceutical research applications. -
Androgen/HSV-1 Inhibitor
Brassicasterol is a metabolite of Ergosterol that primarily targets androgen pathways and exhibits antiviral activity against HSV-1. It demonstrates significant anticancer potential in prostate cancer by dual modulation of AKT and androgen receptor signaling pathways. Additionally, Brassicasterol inhibits sterol δ 24-reductase, contributing to the slowdown of atherosclerosis progression. Furthermore, it serves as a cerebrospinal fluid biomarker for Alzheimer's disease, highlighting its relevance in neurodegenerative research. -
Bacterial Inhibitor
Bavachalcone is a bacterial inhibitor known for its multifaceted biological activities. It induces apoptosis and enhances autophagy in HepG2 cancer cells, contributing to its anticancer potential. Additionally, Bavachalcone demonstrates anti-neuroinflammatory and antidepressant effects through modulation of the NF-κB pathway. It also inhibits osteoclast differentiation by interfering with ERK and Akt signaling pathways, as well as the expression of c-Fos and NFATc1, and shows a significant inhibitory effect on BACE-1 activity in vitro. -
NA Inhibitor
Urolithin M5 is an orally active inhibitor of influenza virus neuraminidase, exhibiting IC50 values of approximately 174.8 μM to 257.1 μM. It effectively suppresses influenza virus replication, including strains resistant to oseltamivir, while demonstrating neuroprotective properties by reducing reactive oxygen species and inhibiting neuronal apoptosis. Urolithin M5 also promotes neurite outgrowth and protects against lung edema in infected mammals. Additionally, it interacts with key signaling proteins such as IGF1R, MAPK14, AKT1, NFKB1, and EGFR, making it a valuable reagent for research into influenza and neurodegenerative diseases like Alzheimer's.
