Catalog No.
Product Name
Application
Product Information
Citations
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Antibacterial Agent
Antibacterial Agent 201 is an antibacterial compound that disrupts membrane integrity in target organisms. It demonstrates significant efficacy against Staphylococcus aureus strain RN4220, methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa strain PA01, and Escherichia coli strain ANS1, with minimum inhibitory concentrations (MIC99) of 2.0, 1, 8.1, and 2.2 μg/mL, respectively. This reagent is suitable for research applications focused on studying bacterial resistance mechanisms and evaluating antibacterial properties. -
Antibacterial Agent
Antibacterial Agent 48 is a potent antibacterial compound that enhances the efficacy of the beta-lactam antibiotic Ceftazidime by significantly reducing its minimum inhibitory concentration (MIC). This synergy suggests its potential utility in combating antibiotic-resistant bacterial strains and improving treatment outcomes. It is a valuable reagent for research focused on developing novel antibacterial therapies and exploring resistance mechanisms. -
Antimycobacterial Agent
Antimycobacterial agent-1 selectively targets Mycobacterium tuberculosis (M. tuberculosis) H37Ra and exhibits potent antimycobacterial activity with a minimum inhibitory concentration (MIC) of 1 μg/ml. This compound demonstrates relatively low cytotoxicity in normal cells, as evidenced by an IC50 value of 143.2 μg/ml in Vero cells. Its efficacy and safety profile make it a valuable tool for research focused on tuberculosis and antimycobacterial drug development. -
Antibacterial Agent
Antibacterial Agent 94 is a potent antibacterial compound that demonstrates significant activity against MRSA persisters. This agent disrupts bacterial membrane integrity and interferes with the synthesis of phosphatidylglycerol (PG). Its mechanism of action makes it a valuable tool in the research of antibacterial therapies and the exploration of drug resistance in pathogenic bacteria. -
Bacterial
Berninamycin A is a cyclic thiopeptide antibiotic that targets Gram-positive bacteria by inhibiting protein biosynthesis through specific binding to ribosomal subunits. Initially isolated from Streptomyces bernensis, this compound also induces the transcriptional activator TipA in Streptomyces, highlighting its role in antimicrobial research. Berninamycin A is valuable for studies involving antibiotic resistance mechanisms and the development of new antibacterial agents. -
Antibacterial Agent
Asperglaucin B is an alkylated salicylaldehyde derivative derived from the fungus Aspergillus chevalieri SQ-8, recognized for its antibacterial properties. This compound exhibits potent antibacterial activity against plant pathogens, specifically Pseudomonas syringae pv actinidae and Bacillus cereus, with a minimum inhibitory concentration (MIC) of 6.25 μM. Asperglaucin B serves as a valuable tool in research focused on plant disease control and the development of novel antibacterial agents. -
Bacterial Inhibitor
8-Epidiosbulbin E acetate is a furanoid compound derived from Dioscorea bulbifera L. It functions as a bacterial inhibitor, demonstrating broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. Additionally, it has been noted to induce liver injury in murine models, highlighting its potential impact on liver function. This compound is valuable for research involving antibiotic resistance and bacterial pathogenicity. -
Bacterial Inhibitor
FtsZ-IN-10 is a bacterial division inhibitor that targets the assembly of FtsZ, a critical protein involved in bacterial cytokinesis. By binding specifically to Bacillus subtilis FtsZ monomers, FtsZ-IN-10 disrupts their polymerization, ultimately hindering the formation of the Z ring and inhibiting cell division. This compound has demonstrated efficacy against antibiotic-resistant clinical isolates, including Staphylococcus aureus and Enterococci, making it a valuable tool in microbiological research and antibiotic development. Additionally, FtsZ-IN-10 may stimulate nucleotide-free archaeal FtsZ to form structured polymers, contributing to its versatile applications in studying bacterial growth and division mechanisms. -
Metallo-β-Lactamase Inhibitor
EBL-3183 is a potent inhibitor of metallo-β-lactamases (MBLs) that targets the NDM-1 enzyme. This indole-2-carboxylate compound exhibits reversible, non-covalent, and competitive inhibition characterized by a pIC50 value of 7.7. EBL-3183 is valuable for research applications focused on combating antibiotic resistance and exploring mechanisms of MBL inhibition. -
β-lactamase Inhibitor
Xeruborbactam methoxy acetoxy methyl ester is a boronic acid derivative specifically designed as a β-lactamase inhibitor. This compound effectively inhibits the enzymatic activity of β-lactamases, which are responsible for antibiotic resistance in various bacterial strains. It is primarily utilized in research applications aimed at understanding β-lactamase mechanisms and developing novel antimicrobial therapies. -
Antibacterial Agent
Mycolic acid IIa is a key structural lipid of the mycobacterial cell wall, primarily sourced from Mycobacterium bovis BCG. This compound plays a crucial role in modulating membrane permeability and stability, making it a valuable tool for research on Mycobacterium tuberculosis infections. Its antibacterial properties support studies aimed at understanding mycobacterial pathogenesis and developing new therapeutic approaches. -
Bacterial Inhibitor
Ianthelliformisamine C ditrifluoroacetate is a bacterial inhibitor that enhances the activity of antibiotics against resistant Gram-negative bacteria. This compound has been shown to significantly improve the efficacy of doxycycline against Pseudomonas aeruginosa. Its mechanism of action involves inducing ATP efflux and causing membrane depolarization in bacterial cells. Ianthelliformisamine C ditrifluoroacetate is synthesized using peptide coupling, resulting in high chemical yields ranging from 27% to 91%, making it a valuable tool for research in combating antibiotic resistance. -
Antibacterial Agent
Ilicicolin C is an antibacterial agent with demonstrated efficacy against Pseudomonas syringae, exhibiting an IC50 of 28.5 µg/mL. Additionally, it has shown weak inhibitory effects on acetylcholinesterase and β-glucuronidase, with IC50 values ranging from 30 to 43 µg/mL. The compound also displays weak cytotoxicity in human lung fibroblasts, with IC50 values of 64 to 120 µg/mL. Furthermore, Ilicicolin C influences seed germination and root tip growth in lettuce, indicating potential implications in plant research. -
Bacterial Inhibitor
Protactin is a pentapeptide lactone that targets bacterial growth, derived from the Streptomyces cucumeris strain L703-4 (ATCC 53784). This compound demonstrates significant antioxidant properties and can be converted to actinomycin Zp through ferrocyanide oxidation, which displays potent antibacterial activity in vitro. Additionally, actinomycin Zp has been shown to possess substantial antitumor effects against P-388 leukemia in murine models, making it a valuable reagent for cancer research and microbiological studies. -
Antibacterial Agent
Olamufloxacin is an orally active fluoroquinolone antibacterial agent that exerts its effect by targeting bacterial DNA gyrase and topoisomerase IV. This compound demonstrates broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria and effectively inhibits the growth of extracellular Legionella species as well as intracellular Legionella pneumophila. Olamufloxacin also mitigates cytotoxicity associated with Legionella pneumophila and has been shown to increase survival rates and decrease lung bacterial burden in infected guinea pig models. This reagent is valuable for research focused on legionnaires’ disease and its underlying pathogenic mechanisms. -
Bacterial Inhibitor
Cyclo(Leu-Ala) is a cyclic dipeptide with demonstrated antimicrobial properties targeting bacterial pathogens. This compound exhibits significant inhibitory activity against various plant pathogens, making it a valuable tool in studies involving plant-microbe interactions and the development of novel antimicrobial agents. Its potential applications include agricultural research and the investigation of natural products for controlling plant diseases. -
Antibacterial Agent
Syringopicroside is a natural compound derived from Syringa oblata Lindl. It exhibits significant antibacterial activity, making it a valuable tool for research into microbial infections and potential therapeutic applications. This compound is of interest for studies exploring the mechanisms of action against a variety of bacterial strains. -
Bacterial Inhibitor
Haplopine is a bacterial inhibitor that exhibits photo-activated antimicrobial properties. It demonstrates the ability to bind to DNA, making it a valuable tool for research applications focused on bacterial infections and microbial resistance. This compound is beneficial in studies investigating the mechanisms of antimicrobial action and the potential development of novel therapeutic strategies. -
Antibacterial Agent
8,9-Dehydro-7,9-diisobutyryloxythymol is a derivative of thymol that exhibits antibacterial properties. This compound demonstrates selective inhibitory activity against Gram-positive bacteria, notably Bacillus cereus, while showing no detectable cytotoxicity against human cancer cell lines in vitro. 8,9-Dehydro-7,9-diisobutyryloxythymol is valuable for research applications focused on bacterial infections and developing antibacterial agents. -
Bacterial Inhibitor
Forphenicinol is a bacterial inhibitor that acts as an immunomodulator, derived from the bacterial metabolite forphenicine. It enhances the phagocytic activity of peritoneal macrophages and is effective in mitigating cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH) in murine models. Forphenicinol increases macrophage bactericidal activity against Pseudomonas aeruginosa and improves survival rates in mouse models of P. aeruginosa infection. Additionally, it demonstrates anti-tumor effects in S180 sarcoma and IMC carcinoma xenograft models, with effective dosing ranging from 0.05 to 5 mg/kg per day. -
Antibacterial Peptide
Acetyl-Adhesin (1025-1044) amide is a 20-peptide fragment derived from the cell surface adhesin of Streptococcus pyogenes, functioning as an antibacterial peptide. This compound specifically inhibits the interaction between adhesin and salivary receptors, thereby preventing the recolonization of Streptococcus pyogenes. Its potential applications include studies in microbial pathogenesis and the development of novel antimicrobial strategies. -
Antibacterial Agent
Antibacterial Agent 96 (compound 4k) is a potent antibacterial compound that targets Mycobacterium tuberculosis, demonstrating significant antitubercular activity against both drug-susceptible and multidrug-resistant strains. This agent is valuable for research applications focused on tuberculosis treatment, particularly in the face of emerging resistance. However, it is important to note that Antibacterial Agent 96 exhibits toxicity to HepG2 and Vero cell lines. -
Antibacterial Agent
3,4-Seco-mansumbinoic acid is an antibacterial agent isolated from the oleo-resin of *Commiphora molmol*. This compound demonstrates significant in vitro anti-staphylococcal activity, particularly against the multidrug-resistant strain *Staphylococcus aureus* SA-1199B, with a minimum inhibitory concentration (MIC) of 4 μg/mL. Additionally, 3,4-Seco-mansumbinoic acid shows weak potentiation of Ciprofloxacin and Tetracycline against *Salmonella enterica* serovar Typhimurium strains. This compound is valuable for research focused on multidrug-resistant bacterial infections. -
Bacterial Inhibitor
Glyasperin D is a flavonoid derived from Glycyrrhiza uralensis that demonstrates antibacterial properties, specifically as a bacterial inhibitor against Helicobacter pylori. Its biological activity suggests potential applications in research focused on bacterial infections and the development of antibacterial agents. This compound may serve as a valuable tool in studying H. pylori-related diseases and exploring flavonoid mechanisms in bacterial inhibition. -
Antibacterial Agent
LAB 149202F is an acylanilide antibacterial agent that exerts inhibitory effects on bacterial strains exhibiting formyl and phosphate resistance. This compound demonstrates significant antimicrobial activity, making it a valuable tool for research into antibiotic resistance mechanisms and the development of new therapeutic strategies. Its application in various biological assays supports the exploration of bacterial pathogenesis and antibiotic efficacy. -
Antibacterial Agent
Desethylene Ciprofloxacin hydrochloride functions as an antibacterial agent, derived from the metabolism of Ciprofloxacin. It acts primarily as a topoisomerase IV inhibitor, contributing to its antibacterial properties. This compound is suitable for research applications focused on antibacterial mechanisms and the study of bacterial resistance. -
Antibacterial Agent
Antibacterial Agent 130 is a 1,1-diarylthiogalactoside that specifically targets the lectin LecA from Pseudomonas aeruginosa. It exhibits a high affinity for LecA, with a Kd of 1 μM, demonstrating effective antibiofilm activity. Although it does not possess bactericidal properties, it is valuable for research into bacterial adhesion and biofilm formation, making it a useful tool in studies of Pseudomonas aeruginosa virulence and infection mechanisms. -
Bacterial Inhibitor
JM 1397 is a potent antibacterial agent with a primary mechanism of action against bacterial pathogens. It demonstrates significant antibacterial activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC90) of 1 μg/mL. This compound is valuable for research in antibiotic resistance and the development of new antimicrobial therapies. -
Bacterial Inhibitor
Gyramide A is a bacterial inhibitor that targets bacterial topoisomerases. It has been shown to exhibit a unique mechanism of action distinct from other topoisomerase inhibitors, highlighting its potential in studies related to bacterial resistance. Gyramide A is valuable for research applications aimed at understanding the protective effects of Qnr proteins on bacterial enzymes and developing novel antibacterial strategies. -
Antibiotic
Gatifloxacin sesquihydrate is a potent fluoroquinolone antibiotic that primarily targets bacterial type II topoisomerases. It exhibits broad-spectrum antibacterial activity, demonstrating significant inhibition of S. aureus topoisomerase IV and E. coli DNA gyrase with IC50 values of 13.8 μg/ml and 0.109 μg/ml, respectively. This compound is particularly useful in research related to bacterial infections and may serve as a therapeutic agent for conditions such as bacterial conjunctivitis. -
Antibacterial Agent
Ticarcillin is a semisynthetic carboxypenicillin with extended-spectrum antibacterial activity, primarily targeting bacterial cell wall synthesis. It is effective against a range of gram-positive cocci, such as streptococci and staphylococci, as well as most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin is relevant for research applications involving lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intra-abdominal infections. -
Antibiotic
Secnidazole hemihydrate is an orally active azole antibiotic that targets bacterial virulence through its amelioration of Serratia marcescens. This compound acts as an analog of acylhomoserine lactones, effectively inhibiting quorum sensing and reducing the pathogenesis of Pseudomonas aeruginosa. Secnidazole hemihydrate demonstrates antimicrobial activity against a range of anaerobic Gram-negative and Gram-positive bacteria in vitro. Its versatile applications in research include the study of diseases such as amoebiasis, giardiasis, and bacterial vaginitis. -
Antibiotic
Teixobactin is a potent antibiotic that primarily targets cell wall synthesis in bacteria. It demonstrates significant antibacterial activity against gram-negative bacteria by binding to the conserved motifs of lipid II and lipid III. This mechanism of action makes Teixobactin a valuable reagent for research focused on bacterial resistance and the development of new antibiotic therapies. -
Antibiotic
Sitafloxacin hydrochloride is a potent fluoroquinolone antibiotic that functions by inhibiting bacterial DNA gyrase and topoisomerase IV, ultimately disrupting bacterial replication. It exhibits significant antibacterial activity against a wide spectrum of both gram-positive and gram-negative bacteria, including anaerobic organisms and atypical pathogens. This compound is primarily applied in research related to respiratory and urinary tract infections. -
Antibiotic
Amoxicillin arginine is an antibiotic that effectively inhibits cell wall biosynthesis by targeting polypeptide synthesis, leading to the disruption of bacterial growth. With good oral absorption and a broad spectrum of antimicrobial activity, it is utilized in various research applications related to bacterial infections and resistance mechanisms. This compound serves as an important tool for studying the pharmacological effects of β-lactam antibiotics in both clinical and laboratory settings. -
Antibiotic
Zanamivir (hydrate)(5:1) is a potent inhibitor of influenza viral neuraminidase, exhibiting IC50 values of 0.95 nM for influenza A and 2.7 nM for influenza B. This compound is widely employed in antiviral research to elucidate the mechanisms of viral infection and to develop therapeutic strategies against influenza viruses. Its high inhibitory efficacy makes it a valuable tool for studying the effects of neuraminidase inhibition in both laboratory and clinical settings. -
Antibacterial Agent
Cloxacillin is an orally active antibacterial agent and β-lactamase inhibitor, exhibiting an IC50 of 0.04 µM. It effectively suppresses the inflammatory response induced by Staphylococcus aureus by inhibiting the activation of mitogen-activated protein kinases (MAPKs), nuclear factor kappa B (NF-κB), and proteins associated with the NLRP3 inflammasome. This compound is useful for research applications focused on bacterial infections and inflammatory processes. -
Cephalosporin Antibiotic
Cefotiam is a parenteral cephalosporin antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, making it a valuable reagent for research in microbiology and infectious disease studies. This compound is commonly used in evaluating bacterial susceptibility and understanding the mechanisms of antibiotic resistance. -
Antibiotic
Netilmicin is a broad-spectrum semisynthetic aminoglycoside antibiotic targeting bacterial protein synthesis. It demonstrates significant antibacterial activity against aminoglycoside-susceptible gram-negative strains as well as aminoglycoside-resistant strains, including Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with a minimum inhibitory concentration (MIC) ranging from 0.125 to 8 μg/mL. This compound is widely used in research applications focusing on antimicrobial susceptibility and resistance mechanisms. -
Antibiotic
Cefepime chloride is a broad-spectrum cephalosporin antibiotic that effectively targets both Gram-positive and Gram-negative aerobic bacteria. Its ability to penetrate the blood-brain barrier makes it a valuable agent in the treatment of central nervous system infections. Additionally, it is noted for its neurotoxic effects, making it relevant for studies investigating antimicrobial toxicity and resistance mechanisms. -
Antibacterial Antibiotic
Tebipenem pivoxil hydrochloride is an orally active antibacterial agent that targets penicillin-binding proteins (PBPs) to inhibit cell wall synthesis in pathogenic bacteria. This mechanism of action makes it effective against a broad spectrum of Gram-positive and Gram-negative organisms. It is utilized in research applications focused on antibiotic resistance and the development of novel antibacterial therapies. -
Cephalosporin Antibiotic
Cephalexin hydrochloride monohydrate is a semisynthetic cephalosporin antibiotic that primarily targets penicillin-binding proteins (PBPs) to disrupt bacterial cell wall synthesis. It exhibits a wide antibacterial spectrum, effective against various gram-positive and gram-negative bacteria. This compound is utilized in research related to bacterial infections, including pneumonia, strep throat, and bacterial endocarditis. -
Dianionic Cephem Antibiotic
Ceftibuten monohydrate is a dianionic cephem antibiotic that exhibits potent antibacterial activity. It is effective against a broad spectrum of gram-negative bacteria and select gram-positive strains. Ceftibuten is primarily utilized in research applications focusing on antibiotic resistance and the pharmacological evaluation of cephalosporins. Its oral bioavailability makes it a valuable compound for studying systemic infection models. -
Antibiotic
Sitafloxacin monohydrate is a potent fluoroquinolone antibiotic that exhibits strong antibacterial activity against a wide spectrum of both gram-positive and gram-negative bacteria, including anaerobic organisms and atypical pathogens. Its antichlamydial properties make it a valuable reagent in the study of various infections. Sitafloxacin monohydrate is particularly relevant in research focused on respiratory and urinary tract infections. -
Cephalosporin Antibiotic
Cephalexin (lysine) is a semisynthetic cephalosporin antibiotic that primarily targets penicillin-binding proteins (PBPs) to disrupt bacterial cell wall synthesis. This compound exhibits broad-spectrum antibacterial activity against a range of gram-positive and gram-negative bacteria. Cephalexin (lysine) is used in research applications related to various infections, including pneumonia, streptococcal throat infections, and bacterial endocarditis. -
β-lactam Antibiotic
Dicloxacillin is a β-lactam antibiotic belonging to the penicillin family, primarily targeting Gram-positive bacteria. It demonstrates effectiveness against β-lactamase-producing organisms, including Staphylococcus aureus. This compound is widely utilized in research and clinical applications to investigate bacterial resistance mechanisms and evaluate the efficacy of antibacterial treatments. -
Antibiotic
A83016A is a kinamycin-type antibiotic that inhibits bacterial growth by targeting essential cellular processes. It exhibits a minimum inhibitory concentration (MIC) of 4 µg/ml against Enterococcus faecium, demonstrating its potent antibacterial activity. This compound is suitable for research applications focused on antibiotic resistance and efficacy studies in microbiology. -
Antibiotic
Antibiotic SF-2132 is a peptide antibiotic derived from Nocardiopsis sp., demonstrating potent inhibitory activity against β-lactam antibiotic-resistant strains, including Pseudomonas and Escherichia. This compound is particularly valuable in research aimed at addressing antibiotic resistance and investigating novel antimicrobial mechanisms. Its efficacy against resistant pathogens makes it a crucial tool for studies in microbiology and infectious disease. -
Antibiotic
Aurodox is an antibiotic derived from a variant of Streptomyces, primarily targeting gram-positive bacteria. It exhibits potent antibacterial activity while demonstrating low toxicity in murine models. Aurodox is utilized in research applications related to antibiotic efficacy and potential growth promotion in agricultural settings. -
Cephalosporin Antibiotic
Cefetecol is a broad-spectrum cephalosporin antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis, leading to cell lysis. In addition to its antibacterial properties, Cefetecol also acts as an α-glucosidase inhibitor, demonstrating in vivo anti-diabetic activity in diabetic mouse models. This compound is suitable for research applications in both antibacterial and anti-diabetic studies.
