Catalog No.
Product Name
Application
Product Information
Citations
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Antibiotic
Echinosporin is an antibiotic derived from the Amycolatopsis strain, primarily functioning as an antifungal agent. This compound exhibits potent biological activity against various fungal pathogens and demonstrates antitumor properties, making it a valuable reagent for research in microbiology and cancer biology. Its unique mechanism of action provides a useful tool for studies aimed at understanding antifungal resistance and evaluating therapeutic strategies in oncological contexts. -
Antifungal Agent
Antifungal Agent 61 primarily targets and inhibits V. mali, exhibiting an EC50 value of 0.50 mg/L. This compound disrupts fungal cellular integrity by inducing deformation and contraction, leading to a reduction in intracellular mitochondria, thickening of the cell wall, and increased permeability of the cell membrane. Antifungal Agent 61 is a valuable reagent for research applications focused on understanding fungal pathogenesis and developing antifungal therapies. -
Secondary Metabolite
Neosartoricin, a prenylated anthracenone, targets immunological pathways as a secondary metabolite. Isolated from Aspergillus fumigatus and Neosartorya fischeri, Neosartoricin exhibits notable immunosuppressive activity, significantly inhibiting T-cell proliferation with an IC50 of 3 μM. This compound may play a role in fungal defense mechanisms by dampening host adaptive immunity, potentially aiding in the establishment of infection without directly influencing primary virulence factors. -
Antifungal Agent
Quindecamine acetate is an antifungal agent that targets fungal cell membranes, disrupting their integrity. This compound exhibits significant antifungal activity, making it suitable for studies related to fungal infections and the development of antifungal therapies. Its mechanism of action and efficacy make it a valuable reagent for researchers exploring antifungal drug development and resistance mechanisms. -
SDH Inhibitor/Antifungal Agent
SDH-IN-13 (Compound 5IIIh) is an inhibitor of succinate dehydrogenase (SDH) with an IC50 of 13.7 μg/mL. This compound exhibits antifungal activity, making it a valuable tool in the study of fungal pathogens and mitochondrial function. Its selective targeting of SDH positions it as a promising candidate for further research in antifungal therapies. -
Antibiotic
Fistupyrone is an antibiotic compound derived from the microbial metabolite of Streptomyces sp. TP-A0569. It exhibits significant activity against Alternaria brassicicola, effectively inhibiting the growth of this pathogen in infected Chinese cabbage. This compound is valuable for research applications focused on plant microbiology and the development of bioactive agents for agricultural protection. -
Antifungal/Antibacterial Benzoquinone
Anserinone B is a benzoquinone recognized for its antifungal and antibacterial properties. It effectively inhibits the radial growth of S. fimicola and A. furfuraceus by 50% and 37%, respectively. Additionally, Anserinone B exhibits moderate cytotoxicity against a broad range of human tumor cell lines, as demonstrated by a GI50 value of 4.4 µg/mL in the NCI’s 60 cancer cell line panel. This compound is relevant for research in antimicrobial therapies and cancer treatment. -
Antifungal Agent
Butenafine is a potent benzylamine antifungal agent that targets squalene epoxidation in the ergosterol biosynthesis pathway, leading to impaired cell membrane integrity in fungi. It demonstrates broad-spectrum activity against various dermatophyte infections, including tinea pedis, tinea cruris, and tinea versicolor. This compound is valuable for research applications focused on antifungal mechanisms and the development of treatments for fungal infections. -
Antifungal Agent
Fumitremorgin B is a tremorgenic mycotoxin with notable antifungal properties. This compound demonstrates significant antifungal activity, exhibiting minimum inhibitory concentrations (MICs) ranging from 6.25 to 50 μg/mL. Fumitremorgin B serves as a valuable reagent for research in mycology, the study of fungal pathogens, and exploring mechanisms of antifungal resistance. -
Antifungal Agent
Triforine is a systemic antifungal agent that exhibits moderate to pronounced fungitoxic activity against various pathogenic and non-pathogenic fungi. It operates by inhibiting fungal growth, making it an effective tool for studying fungal interactions and antifungal mechanisms. Triforine is suitable for research applications in mycology and agricultural science, contributing to the understanding and management of fungal diseases. -
Benzimidazole Fungicide
Carbendazim hydrochloride is a benzimidazole fungicide that exerts its activity through disruption of microtubule dynamics, targeting fungal cell division. It demonstrates broad-spectrum antifungal activity and is commonly utilized in research focused on fungal diseases, including Septoria, Fusarium, and Sclerotinia. Additionally, carbendazim hydrochloride exhibits antitumor properties, making it applicable in cancer research, particularly in the study of advanced solid tumors and lymphoma. -
Antibiotic
Anguinomycin A is an antibiotic with potent inhibitory activity against Ganoderma boninense, exhibiting a minimum inhibitory concentration (MIC) of 5 µg/disk. In addition to its antibacterial properties, Anguinomycin A demonstrates significant antitumor activity. This compound is valuable for research in microbial resistance and cancer therapeutics. -
Antifungal Agent
Antifungal Agent 74 is a potent antifungal compound that exhibits significant fungicidal activity against pathogens such as Colletotrichum arachidicola and Rhizoctonia solani. Its mechanism of action involves the disruption of steroid biosynthesis and ribosome biogenesis in eukaryotic organisms, making it a valuable tool in antifungal research and the study of fungal pathogenesis. Suitable for applications in both laboratory and agricultural settings, Antifungal Agent 74 offers potential for the development of new antifungal strategies. -
antifungal
Lactose octaacetate primarily exhibits antifungal activity, demonstrating mild to moderate effects against certain fungi while showing minimal or no activity against bacteria and yeast. This compound displays low cytotoxicity toward MDBK, Hep-2, and MDCK cells, making it a candidate for further safety assessments in biological research. Additionally, lactose octaacetate has been identified to possess antiviral properties against PV-1, suggesting potential applications in virology studies. -
Anti-Plant Pathogenic Fungal
Verlamelin B is a novel compound targeting plant pathogenic fungi. It demonstrates significant protective activity in vivo, particularly against rice blast and barley powdery mildew, providing insights into antifungal mechanisms. Furthermore, Verlamelin B induces morphological alterations in fungal cells, including swelling and expansion. Despite its weaker in vitro activity against certain plant pathogens like Dipolaris zeae and Botrytis cinerea, this compound is a valuable tool for research into antifungal strategies against agricultural pathogens. -
SDH Inhibitor
SDH-IN-4 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 0.28 μg/mL. This compound demonstrates potent antifungal activity, specifically against Rhizoctonia solani, with an EC50 value of 0.23 μg/mL. SDH-IN-4 is primarily utilized in research applications involving fungal pathogen studies and metabolic pathway analysis. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 6 is a potent inhibitor of chitin synthase (CHS) with an IC50 value of 0.21 mM. This compound exhibits broad-spectrum antifungal activity against drug-resistant fungi, making it a valuable tool in the study of fungal infections. It is applicable in research focused on understanding fungal pathogenesis and developing antifungal therapies. -
Phytotoxin
Neovasinin is a phytotoxin derived from the fungus Neocosmospora vasinfecta. It demonstrates significant toxicity towards soybean plants, serving as a valuable model for studying plant-fungal interactions and the mechanisms of plant defense. This compound can be utilized in research focused on plant pathology and agricultural biotechnology. -
Fungal Inhibitor
Antifungal Agent 68 is a potent inhibitor targeting fungal ergosterol biosynthesis, with demonstrated efficacy against Candida species and Cryptococcus gattii. This compound likely exerts its antifungal effects by inhibiting lanosterol 14α-demethylase (CYP51), wherein its imidazole ring interacts with the heme group of the enzyme. It serves as a valuable tool for research into fungal infections and the development of novel antifungal therapies. -
Antifungal Agent
Amcipatricin L-aspartate is a semi-synthetic polyene antibiotic that targets fungal cell membranes, exhibiting potent broad-spectrum antifungal activity. This reagent is suitable for research applications focused on fungal infections and the development of antifungal therapies. Its ability to disrupt cellular integrity makes it a valuable tool in studying antifungal mechanisms and treatment strategies. -
Antifungal Antibiotic
Aranorosin is a potent antifungal antibiotic that targets fungal cell membrane integrity. Isolated from the culture filtrate and mycelium of the fungus Pseudoarachniotus roseus Kuehn, it exhibits significant antifungal activity against various pathogenic fungi. This compound is valuable for research applications focused on fungal pathogenesis and therapy development. -
β-1,3-Glucan Inhibitor
Ibrexafungerp phosphate is a selective inhibitor of β-1,3-glucan synthesis, exhibiting notable antifungal activity. This compound is primarily utilized in research related to fungal pathogens, particularly for investigating infections caused by Candida and Aspergillus species. Its mechanism of action disrupts the integrity of the fungal cell wall, making it a valuable tool for exploring antifungal therapies. -
Ole1p Inhibitor
N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is an inhibitor of Ole1p desaturase, an important enzyme in the biosynthesis of unsaturated fatty acids. This compound exhibits antifungal activity, making it a valuable tool for research in antifungal drug development and lipid metabolism studies. It is suitable for investigating the mechanisms of fungal resistance and characterizing lipid profiles in various biological systems. -
Fungicidal Agent
Antibacterial agent 157 (compound B12) is a potent fungicidal agent that inhibits protein synthesis in the fungal pathogen Botrytis cinerea. This compound is valuable for research applications focused on gray mold resistance control, providing insights into effective strategies for managing plant diseases associated with this pathogen. -
Antibacterial Peptide
Metchnikowin is an antibacterial peptide derived from fruit flies, exhibiting potent antimicrobial properties against both bacteria and fungi. Its activity is regulated through the TOLL and IMD signaling pathways, making it a valuable tool for studying immune responses in various infectious conditions. This peptide is widely utilized in research focused on host defense mechanisms and the development of novel antimicrobial agents. -
Antifungal Agent
Asperfuran is an antifungal dihydrobenzofuran derivative derived from Aspergillus oryzae. It exhibits a weak inhibitory effect on chitin synthase from Coprinus cinereus, contributing to its antifungal activity. Additionally, Asperfuran demonstrates weak cytotoxicity in HeLa S3 and L1210 cell lines, with an IC50 of 25 μg/ml, making it a potential candidate for research involving fungal infections and cytotoxicity studies. -
Anti-Saprolegnia compound
Quellenin is an anti-saprolegnia compound derived from the deep-sea fungus Aspergillus sp. YK-76. It exhibits potent inhibitory activity against Saprolegnia species, making it a valuable tool in research applications focused on fungal infections in aquatic environments. This compound is particularly relevant for studies investigating antifungal agents and their potential use in aquaculture. -
Dimeric Antioxidant
Scirpusin B is a dimeric antioxidant derived from Scirpus maritimus L. It demonstrates notable biological activities, including antitumor, antifungal, insecticidal, and plant growth inhibitory effects. This compound is useful in research related to oxidative stress, cancer biology, and agricultural applications. -
Fungal Inhibitor
Antifungal agent 13 is a potent fungal inhibitor specifically targeting Sclerotinia sclerotiorum, exhibiting an effective concentration (EC50) of 1.25 mg/L. This compound demonstrates significant antifungal activity, making it a valuable tool for research into fungal pathogenesis and susceptibility. Its application includes studies aimed at understanding fungal resistance mechanisms and the development of novel antifungal therapies. -
Polyketide
(-)-Mitorubrinic acid is a polyketide that serves as a virulence factor for Penicillium marneffei. It is synthesized through the activity of two non-reducing polyketide synthase (PKS) genes, pks12 and pks11, operating in a sequential manner. This compound enhances the intracellular survival of P. marneffei within macrophages, making it significant for research on fungal pathogenesis and virulence mechanisms. -
Phytoalexin
Noraucuparin is a biphenyl-type phytoalexin that exhibits significant antifungal activity. This compound is of interest in botanical research due to its natural defense role in plants, particularly in response to pathogenic attacks. Isolated from the leaves of Sorbus pohuashanensis, noraucuparin serves as a valuable tool for studying plant-pathogen interactions and the mechanisms of phytochemical defenses. -
Anti-bacterial Peptide
Pseudin-2 is an antimicrobial peptide derived from the skin of the South American paradoxical frog, Pseudis paradoxa. It exhibits potent growth inhibition against Gram-negative bacteria, making it a valuable tool for antibacterial research. Pseudin-2 may be utilized in studies aimed at understanding antimicrobial mechanisms and developing new therapeutic strategies against resistant bacterial strains. -
Antifungal Reagent
L685818 is a specific immunophilin ligand that exhibits antifungal activity against Cryptococcus neoformans. In addition to its antifungal properties, L685818 demonstrates neuroregenerative effects by safeguarding dopaminergic neurons from toxicity associated with MPP+ and 6-OHDA. The compound effectively reduces the loss of tyrosine hydroxylase (TH) and promotes neuronal process regeneration, making it a valuable tool for research in neurodegenerative disease models and fungal infections. -
Fungal Inhibitor
Diethofencarb is a fungicide that exhibits potent activity against Botrytis cinerea and Benzimidazole-resistant strains of Botrytis species. It functions primarily as an antifungal agent in agricultural applications, demonstrating efficacy in managing fungal pathogens in crops. Researchers may utilize Diethofencarb for studies related to fungal resistance mechanisms and the development of sustainable pest management strategies. -
Antifungal Agent
Neophellamuretin is a flavonoid that acts as an antifungal agent. It demonstrates potent inhibitory activity against Trichophyton species, with a minimum inhibitory concentration (MIC) value of 62.5 µg/mL. This compound is suitable for research applications focused on fungal infections and the development of antifungal therapies. -
Antifungal Agent
Antifungal Agent 95 (Compound CN21b) is an effective antifungal compound targeting Sclerotinia sclerotiorum and Botrytis cinerea, demonstrating EC50 values of 2.11 μM and 0.97 μM, respectively. This agent shows significant antifungal activity against resistant B. cinerea strains, with EC50s below 10 μM. It is suitable for research applications aimed at understanding fungal resistance mechanisms and the development of antifungal strategies. -
Antifungal Agent
Embeconazole is an antifungal agent primarily targeting key pathogens such as Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, and Aspergillus flavus, with minimum inhibitory concentrations (MICs) of 8, 16, 63, and 250 μM, respectively. This compound demonstrates significant antifungal activity, making it suitable for research applications focused on fungal infections and the development of antifungal therapies. Its efficacy against various fungal species highlights its potential use in both clinical and laboratory settings for studying fungal pathogenesis and treatment options. -
Fungal Inhibitor
Antifungal agent 11 targets fungal organisms by inhibiting key metabolic processes, demonstrating significant antifungal activity. This compound is valuable in research applications aimed at understanding fungal behavior and developing new antifungal treatments. Its efficacy against various fungal strains makes it an essential tool for studying fungal infections and resistance mechanisms. -
Fungal
Bivittoside B is a non-sulfated hexoside analog that targets fungal cells, exhibiting significant antifungal properties. This compound has demonstrated potential antitumor activities, making it a valuable tool for research in mycology and cancer biology. Its unique structure and biological activity may provide insights into novel therapeutic strategies against fungal infections and tumors. -
Antifungal Agent
Fluazinam impurity 1 is an impurity associated with the antifungal agent Fluazinam. It exhibits significant antifungal activity against various pathogens, including Sphaerotheca fuliginea, Pyricularia oryzae, and Rhizoctonia solani. This compound serves as a valuable tool for research focused on antifungal mechanisms and can aid in the development of strategies to combat fungal infections in agricultural settings. -
Antifungal Agent
Antifungal Agent 69 is a eugenol-imidazole compound exhibiting potent activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 4.6 μM. It effectively disrupts ergosterol biosynthesis in fungi, contributing to its antifungal properties. This compound demonstrates minimal cytotoxicity, making it suitable for further research in antifungal treatments and mechanisms of action. -
Anti-MTB/Antifungal Agent
Bromoflavone, a flavone derived from Aspergillus candidus, primarily targets Mycobacterium tuberculosis (MTB) with an MIC90 value of 1.2 μM, demonstrating significant anti-MTB activity. Additionally, it exhibits antifungal properties, inhibiting the growth of pathogenic fungi such as Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, with IC50 values of 0.11, 20, and 0.54 μg/mL, respectively. This compound is valuable for research in tuberculosis and fungal infections, offering insights into potential therapeutic applications. -
Antimicrobial Agent
Biclotymol is an antimicrobial agent primarily targeting gram-positive cocci. It effectively inhibits the growth of Streptococcus pneumoniae and Haemophilus influenzae, displaying a minimum inhibitory concentration (MIC) of 150 μM. Additionally, Biclotymol demonstrates anti-inflammatory and analgesic properties, making it relevant for research applications in otolaryngological infections and throat pain management. -
Antifungal Agent
Alexidine is a bis-biguanide compound with potent antifungal properties, effectively inhibiting a variety of fungal pathogens and demonstrating significant antibiofilm activity. Additionally, Alexidine serves as an anticancer agent by targeting the mitochondrial tyrosine phosphatase PTPMT1 in mammalian cells, inducing mitochondrial apoptosis. This makes Alexidine a valuable reagent for research applications in antifungal therapy and cancer studies. -
CHS Inhibitor
Chitin Synthase Inhibitor 10 is a potent chitin synthase inhibitor, demonstrating an IC50 value of 0.11 mM. This compound exhibits significant antifungal activity, particularly against drug-resistant fungal strains such as Candida albicans and Cryptococcus neoformans. Chitin Synthase Inhibitor 10 is useful in the study of invasive fungal infections (IFIs), providing valuable insights into potential therapeutic strategies. -
Gamma-Glutamyl Transferase Inhibitor
Gamma-Glutamyl Transferase-IN-2 is a potent inhibitor of gamma-glutamyl transferase, a key enzyme involved in amino acid metabolism. This β-carboline 1-hydrazide compound demonstrates significant antifungal and antibacterial activities through its mechanism, which leads to the accumulation of reactive oxygen species, disruption of cell membranes, and alteration of histone acetylation patterns. Gamma-Glutamyl Transferase-IN-2 is valuable for research focused on understanding oxidative stress, cellular integrity, and epigenetic regulation in various biological systems. -
Antifungal Agent
Eriobofuran is an antifungal agent derived from Sorbus aucuparia. It exhibits significant antifungal activity, making it a valuable reagent for studies focused on fungal pathogens. Eriobofuran is applicable in research aimed at understanding fungal resistance mechanisms and developing novel antifungal therapies. -
Antifungal Agent
AB-22 is a vinyl sulfate compound that functions as an orally active antifungal agent. It effectively inhibits hyphal growth and biofilm formation in Candida albicans SC5314 by suppressing the expression of key genes such as ALS3, HWP1, and ECE1. AB-22 is a valuable tool for research into fungal infections, including systemic candidiasis. -
SDH Inhibitor
SDH-IN-6 is a potent inhibitor of succinate dehydrogenase (SDH). This compound demonstrates significant antifungal activity against Valsa mali, exhibiting an EC50 value of 1.77 mg/L. It is a valuable research tool for investigating the role of SDH in fungal metabolism and potential therapeutic approaches for treating fungal infections. -
Antifungal Agent
Antifungal agent 75 (compound 6r) is a potent antifungal compound targeting Candida albicans. It effectively inhibits C. albicans biofilm formation and enhances cell membrane permeability. Additionally, it reduces ergosterol levels, disrupts membrane structure, and compromises cellular integrity, showcasing remarkable antifungal activity. This reagent is suitable for research applications focused on antifungal drug development and cellular membrane studies.
