Microbiology

Items 2401-2450 of 6342

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  1. Antibacterial Agent

    Longistyline A is a natural stilbene that exhibits potent antibacterial activity, particularly against Methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 1.56 μg/mL. In addition to its antimicrobial properties, Longistyline A demonstrates neuroprotective effects, making it a valuable compound for research into infections and neurodegenerative diseases. Its dual role in combating bacterial infections and providing neuroprotection supports its investigation in therapeutic applications within microbiology and neurology.
  2. Anti-bacterial Agent

    Pachybasin is an anti-bacterial agent derived from the culture broth of the endophytic coelomycete AFKR-18. This compound exhibits notable antimicrobial activity against a range of pathogens, including E. coli, B. subtilis, and S. aureus, with minimum inhibitory concentration (MIC) values of 64.0 μg/mL and 16.0 μg/mL, respectively. Pachybasin is valuable for research applications in studying microbial resistance and the development of novel antibacterial therapies.
  3. Bacterial Inhibitor

    (+)-Viroallosecurinine is a potent antibacterial alkaloid that acts as a bacterial inhibitor. It demonstrates significant antimicrobial activity, with a minimum inhibitory concentration (MIC) of 0.48 μg/mL against Pseudomonas aeruginosa and Staphylococcus aureus. This compound is suitable for research applications focused on understanding bacterial resistance and developing novel antibacterial agents.
  4. Antibacterial Agent

    Lactoferricin B (4-14) is an antibacterial peptide derived from bovine lactoferricin. It exhibits notable bactericidal properties and possesses antifungal, antiparasitic, antitumor, and antiviral activities, making it a versatile reagent for various biological research applications. Additionally, Lactoferricin B (4-14) has immunomodulatory effects, contributing to its potential in studies focused on immune response modulation.
  5. Antibacterial Agent

    Antibiofilm agent-1 is an antibacterial agent that targets the growth of Gram-positive pathogens. It exhibits significant efficacy in inhibiting biofilm formation, making it a valuable tool for research into bacterial infections and biofilm-related diseases. This compound can aid in the development of novel antibacterial therapies and enhance understanding of microbial resistance mechanisms.
  6. Antibacterial/Antitumor Drug

    Octacosane is a naturally occurring metabolite known for its antibacterial properties. It demonstrates significant cytotoxicity against murine melanoma B16F10-Nex2 cells and offers protective effects against grafted subcutaneous melanoma. Additionally, Octacosane exhibits larvicidal activity against the mosquito species Culex quinquefasciatus, with an LC50 concentration of 7.2 mg/l, making it a valuable compound for studies in oncology and pest control research.
  7. Antibacterial Agent

    Macrocarpal B is an antibacterial compound primarily derived from the branches of Eucalyptus globulus. This agent exhibits significant antibacterial activity, making it a valuable tool for the investigation of periodontal disease and related infections. Its unique properties facilitate research into bacterial resistance mechanisms and the development of novel therapeutic strategies.
  8. Antibacterial Agent

    AZD5099 is a potent and selective inhibitor of bacterial topoisomerase II, functioning as an effective antibacterial agent. It demonstrates significant activity against Gram-positive bacteria and certain fastidious Gram-negative bacteria, making it valuable for research applications related to bacterial infection models and antibiotic resistance studies.
  9. Bacterial Inhibitor

    Ribocil-C (R enantiomer) is a selective inhibitor targeting bacterial riboflavin riboswitches. This compound disrupts riboflavin biosynthesis by binding to specific RNA structures, effectively inhibiting bacterial growth. It is useful in research applications focusing on bacterial gene regulation and the development of novel antimicrobial strategies.
  10. Antibiotic

    Erythromycin-13C2 is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It exhibits significant antibacterial activity against a variety of gram-positive and some gram-negative bacteria. This compound is primarily utilized in microbiological research and can be instrumental in studies investigating antibiotic resistance and the mechanisms of bacterial infections.
  11. Antibacterial Agent

    (E/Z)-MC4 is an enantiomer of the antibacterial agent MC4, targeting bacterial strains including Staphylococcus aureus, particularly MRSA. This compound exhibits notable antibacterial activity while demonstrating low toxicity to mammalian cells, making it a valuable tool for research in antibacterial efficacy and safety assessments. Its unique profile supports investigations into treatment strategies against antibiotic-resistant infections.
  12. PRRSV Inhibitor

    Atractylodinol is a potent inhibitor of the porcine reproductive and respiratory syndrome virus (PRRSV). It exerts its antiviral activity by binding to vimentin, leading to the inhibition of TGF-β receptor I recycling and the formation of filamentous aggregates. This compound is valuable for research focused on understanding PRRSV pathogenesis and developing therapeutic strategies against viral infections in swine.
  13. Antibacterial Activity

    MurA-IN-4 is a potent MurA inhibitor that disrupts bacterial cell wall synthesis. Its antibacterial activity makes it a valuable reagent for research into bacterial resistance mechanisms and the development of new antimicrobial agents. This compound can be utilized in studies aimed at understanding the efficacy of antibiotics and targeting bacterial infections.
  14. Antibacterial Agent

    Dioxidine, an antibacterial agent, primarily targets bacterial growth inhibition. This compound demonstrates significant activity against a range of bacterial pathogens, making it valuable for research in treatments of suppurative infections. Its application extends to studies focused on infection control and the development of new antibacterial therapies.
  15. Antibacterial Agent

    Tetralin (1,2,3,4-Tetrahydronaphthalene) functions as an antibacterial agent, demonstrating effective inhibition of the growth of Escherichia coli and Arthrobacter strain T2. In addition to its antibacterial properties, tetralin is utilized as a probe molecule in the studies of cracking and hydrotreating processes for light cycle oil, making it valuable for research in both microbiological and chemical engineering applications.
  16. Antibacterial Agent

    1-Methoxyphaseollidin is a flavonoid that functions as a lysoPAF acetyltransferase inhibitor, exhibiting an IC50 of 48 μM. This compound demonstrates significant antibacterial activity against Helicobacter pylori, including strains resistant to clarithromycin and amoxicillin, as well as several clarithromycin-sensitive strains. Its potential applications extend to research in antibiotic resistance and the development of new antibacterial therapies.
  17. Antibacterial Agent

    1-Heptadecanol is a long-chain primary alcohol recognized for its antibacterial properties. It demonstrates effective antibacterial activity against Salmonella gallinarum, with a minimum inhibitory concentration (MIC) of 15.08 μg/mL. This compound can also be utilized in research related to dandruff treatment caused by Malassezia furfur, highlighting its relevance in dermatological studies.
  18. Antibacterial

    Sulfapyridine-d4 is a deuterium-labeled derivative of Sulfapyridine, a sulfonamide antibiotic. This compound exhibits antibacterial activity by inhibiting bacterial folic acid synthesis via competitive inhibition of dihydropteroate synthase. Sulfapyridine-d4 is valuable for pharmacokinetic studies and metabolic research, particularly in tracing and quantifying the behavior of sulfonamide antibiotics in biological systems.
  19. Bacterial

    18:0-18:1 PG sodium is a hydrogenated phospholipid that enhances the structural stability of photosystem I and II protein complexes in bacterial systems. This compound plays a crucial role in the defense mechanisms of bacteria, owing to its unique structural features, including two additional methylene groups in the saturated sn-1 chain. It is found in the thylakoid membranes of higher plants and cyanobacteria, making it valuable for studies involving photosynthetic processes and bacterial interactions.
  20. Metallo-β-Lactamase Inhibitor

    Thiomandelic acid is a potent inhibitor of metallo-β-lactamases, specifically targeting zinc-dependent enzymes. It exhibits broad-spectrum antibacterial activity by effectively preventing the hydrolysis of β-lactam antibiotics. This compound is valuable for research applications focused on antibiotic resistance mechanisms and the development of novel therapeutics against resistant bacterial infections.
  21. Antibacterial Agent

    1-Acetyl-β-carboline is an antibacterial agent derived from Streptomyces kasugaensis. It enhances tyrosinase activity and decreases ERK phosphorylation, demonstrating effective antibacterial properties against methicillin-resistant Staphylococcus aureus (MRSA), with minimum inhibitory concentrations (MICs) ranging from 128 to 256 µg/mL. Additionally, 1-Acetyl-β-carboline is involved in melanin production, making it of interest in studies related to pigmentation and antimicrobial research.
  22. Antibacterial Agents

    Sideroxylonal A is a potent antibacterial agent derived from Eucalyptus jensenii, primarily targeting Gram-positive bacteria. It demonstrates significant activity against Staphylococcus aureus and Bacillus subtilis, making it a valuable compound for research into antibacterial applications. Its unique properties are relevant for studies focusing on marine antifouling strategies and the development of new antimicrobial agents.
  23. Bacterial Inhibitor

    Chloroneb is a bacterial inhibitor with fungicidal properties that effectively protects plants. It is utilized in analytical applications for the detection of organochlorine pesticide residues, demonstrating excellent selectivity, stability, and reproducibility. Chloroneb has been successfully applied in the analysis of various samples, including licorice, cucumber, river water, and soil, providing reliable results for environmental monitoring and agricultural research.
  24. Bacterial Inhibitor

    Amifloxacin is a synthetic antibacterial agent belonging to the quinolone class, primarily targeting bacterial DNA gyrase and topoisomerase IV. This compound exhibits potent bactericidal activity against a broad spectrum of gram-negative and gram-positive bacteria. It is commonly utilized in research applications for studying bacterial infections and evaluating the efficacy of antibiotic treatments.
  25. Bacterial Inhibitor

    Lavendamycin is a quinolinedione with antimicrobial properties, primarily acting as a bacterial inhibitor. It demonstrates significant antibacterial and antitumor activity, making it a valuable compound for research in microbiology and cancer biology. Its unique mechanism and efficacy position Lavendamycin as a potential tool for exploring therapeutic approaches against bacterial infections and tumors.
  26. Antibacterial Agent

    Selenosemicarbazide is an antibacterial agent known for its antimicrobial activity against a range of pathogenic bacteria including Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Sarcina lutea, and Mycobacterium tuberculosis. Additionally, Selenosemicarbazide forms complexes with metal ions, exhibiting potential antitumor efficacy against various cancer cell lines. This compound is valuable for research applications in microbiology and cancer therapeutics.
  27. Fungicide

    Anilazine is a fungicide that primarily targets fungal growth by inhibiting key metabolic pathways. It effectively impedes the growth of organisms such as Rhizobium species and E. coli by disrupting glucose oxidation and succinate oxidation processes. Additionally, Anilazine demonstrates inhibitory effects on succinic dehydrogenase activity in vitro, making it a useful reagent for research applications focused on fungal metabolism and biochemical assays.
  28. Bacterial Inhibitor

    Dodine is a bacterial inhibitor with fungicidal properties, primarily targeting various plant pathogens. It is effective in controlling diseases such as black spot in apples, pears, and pecans, as well as brown rot in peaches, along with a range of foliar diseases affecting strawberries, cherries, jacaranda, and black walnuts. In addition to its agricultural applications, Dodine serves as an industrial biocide and preservative, making it valuable in diverse research settings focused on plant disease management and microbial control.
  29. Antibacterial Agent

    Myramistin is an antibacterial agent that targets bacterial cell membranes. Its cationic properties enable it to bind to the negatively charged surfaces of bacteria, leading to disruption of membrane integrity, inhibition of bacterial metabolism and growth, and ultimately inducing cell death. This compound is widely used in research applications focusing on bacterial pathogenesis and the development of antimicrobial therapies.
  30. Antibiotics

    Dienone B is a marine algicide that demonstrates antibiotic activity against both Gram-positive and Gram-negative marine bacteria. Its unique chemical structure allows it to effectively inhibit bacterial growth, making it a valuable tool for researchers studying marine microbiology and developing new antimicrobial agents for use in aquaculture and environmental applications. Further investigations may explore its potential roles in combating marine biofouling and preserving marine resources.
  31. Antibacterial Agent

    Oleuropeic acid 8-O-glucoside is a terpenic compound that serves as an effective antibacterial agent. It demonstrates notable antibacterial activity against multiple strains of Helicobacter pylori, specifically NCTC11637, NCTC11916, and OCO1, with a minimum inhibitory concentration (MIC) of 100 µg/mL for all. This compound is valuable for research focused on bacterial infections and the development of novel antibacterial therapies.
  32. Bacterial Inhibitor

    Meso-2,6-Diaminopimelic acid serves as a critical biosynthetic precursor in the synthesis of the essential amino acid L-lysine. It plays a vital role in the formation of peptidoglycan, a key structural component of the cell walls in various bacterial species. This compound is primarily utilized in research related to bacterial inhibition and the study of cell wall biosynthesis, making it essential for antimicrobial investigations and the development of antibacterial agents.
  33. Bacterial Inhibitor

    D-Homoserine lactone is a bacterial inhibitor that functions as a signaling molecule regulating quorum sensing through its interaction with acyl-homoserine lactone (AHL) synthase RhlI. By inhibiting RhlI activity, D-Homoserine lactone disrupts bacterial communication, making it a valuable tool in studies of bacterial behavior and pathogenicity. Additionally, as an enantiomer of L-homoserine lactone, it serves as an inhibitor of serine hydroxymethyltransferase, expanding its potential applications in biochemical research and synthetic biology.
  34. Antibacterial Agent

    OX11 is a selective antibacterial agent targeting Streptococcus pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. It demonstrates significant efficacy in inhibiting the growth of these pathogenic bacterial strains. OX11 can be utilized in research applications focused on developing new antimicrobial therapies and studying bacterial resistance mechanisms.
  35. Bacterial Inhibitor

    Afabicin disodium is a specialized bacterial inhibitor that functions as a proagent for Debio1452. It specifically targets Staphylococcus species while exhibiting minimal activity against other Gram-positive and Gram-negative bacteria. The active form, Debio1452, is an inhibitor of FabI, an enzyme essential for fatty acid biosynthesis in staphylococci, making it a valuable tool for research in combating staphylococcal infections.
  36. β-lactamase Inhibitor

    Xeruborbactam bis-acetoxy methyl ester is a boronic acid derivative that functions as a β-lactamase inhibitor. This compound effectively targets β-lactamase enzymes, providing a mechanism to counteract antibiotic resistance in bacterial strains. It is primarily utilized in research focused on developing novel antibacterial therapies and studying the mechanisms of β-lactamase-mediated resistance.
  37. Bacterial Inhibitor

    Epinecidin-1 is a potent antimicrobial peptide derived from the orange-spotted grouper (Epinephelus coioides), targeting various bacterial strains. It exhibits substantial antibacterial, antifungal, antiviral, and antiprotozoal activity, making it a valuable tool in studies examining microbial inhibition. Additionally, its immunomodulatory and wound healing properties further support research applications in infection control and regenerative medicine.
  38. Antibacterial Agent

    Fobrepodacin is an orally administered phosphate proagent of SPR719, exhibiting potent antibacterial activity. This compound demonstrates significant bactericidal effects in vivo, making it a valuable tool for research into antibacterial therapies and infectious disease mechanisms. Its efficacy supports investigations into alternative treatment strategies for bacterial infections.
  39. Antibiotic

    Iboxamycin is a potent antibiotic that targets bacterial ribosomes, inhibiting protein synthesis. This compound demonstrates efficacy against both Gram-positive and Gram-negative bacterial infections, making it a valuable tool for research in microbiology. Its oral bioavailability and safety profile provide significant utility in in vivo studies, particularly in murine models.
  40. Antibacterial Agent

    Sirpefenicol is a phenicol antibacterial agent that targets bacterial protein synthesis. It has demonstrated effectiveness in treating bacterial infections in veterinary medicine. This compound is particularly relevant for research applications focused on antimicrobial resistance and the development of novel antibacterial therapies.
  41. Antibacterial Agent

    MRL-494 is an antibacterial agent that targets the β-barrel assembly machine A (BamA), effectively overcoming efflux mechanisms and the outer membrane permeability barrier. It demonstrates significant antibacterial activity, with a minimum inhibitory concentration (MIC) of 12.5 μM against Staphylococcus aureus (COL) and 25 μM against Escherichia coli (JCM158). This compound is valuable for research into novel antibacterial therapies and mechanisms of resistance in both Gram-positive and Gram-negative bacteria.
  42. Bacterial Inhibitor

    Tuberculosis Inhibitor 3 (Compound 2i) is a potent antibacterial agent targeting Mycobacterium tuberculosis, demonstrating a minimum inhibitory concentration (MIC) of less than 0.016 μg/mL against both sensitive and resistant strains. This compound exhibits favorable pharmacokinetic properties, including adequate oral bioavailability, making it a promising candidate for further research and development in tuberculosis treatment strategies.
  43. Antibacterial Agent

    Octenidine is a potent antibacterial agent that targets multidrug-resistant Gram-negative pathogens. It effectively inhibits the expression of biofilm-associated genes, thereby disrupting biofilm formation. This compound is valuable for research applications focused on combating bacterial resistance and studying biofilm dynamics in various infectious environments.
  44. Bacterial Translation Inhibitor

    NOSO-502 is a bacterial translation inhibitor that targets ribosomal activity in Enterobacteriaceae. It demonstrates potent antibacterial properties while maintaining a favorable safety profile. This compound is suitable for research applications focused on bacterial protein synthesis and the development of novel antimicrobial agents.
  45. Antibacterial Agent

    Antibacterial agent 111 targets tyrosyl-tRNA synthetase, displaying potent antibacterial activity with minimum inhibitory concentration (MIC) values of 3.90 μg/mL against Bacillus cereus and 0.49 μg/mL against Klebsiella pneumoniae. This compound is suitable for research applications focused on resistance mechanisms and the development of novel antibacterial therapies. Its specific action on tRNA synthetase provides insight into protein synthesis inhibition pathways in bacterial pathogens.
  46. Antibacterial Agent

    Miocamycin is a macrolide antibiotic derived from midecamycin, a natural product isolated from Streptomyces mycarofaciens. It exhibits significant antibacterial activity, making it a valuable tool for research in microbiology and antibiotic development. Miocamycin can be utilized to investigate the efficacy of macrolide compounds against various bacterial strains and contribute to the understanding of antibiotic resistance mechanisms.
  47. Bacterial Inhibitor

    Antitubercular agent-10 is a bacterial inhibitor that demonstrates potent antitubercular activity, exhibiting a minimum inhibitory concentration (MIC) of 30 nM. This compound is primarily utilized in research focused on combating tuberculosis, enabling investigations into its mechanisms of action and potential therapeutic strategies. Its effectiveness makes it a valuable tool for studying mycobacterial infections and the development of novel antitubercular therapies.
  48. Antimycobacterial Agent

    Amycolatopsin A is a 20-membered macrolide that acts as an effective antimycobacterial agent. It demonstrates notable inhibitory activity against Mycobacterium bovis (BCG) and Mycobacterium tuberculosis (H37Rv), with IC50 values of 0.4 µM and 4.4 µM, respectively. This compound could be valuable for research applications focused on tuberculosis and related mycobacterial infections.
  49. Bacterial Inhibitor

    CGI-17341 is a 5-nitroimidazole antibacterial agent targeting bacterial pathogens, specifically Mycobacterium tuberculosis. This compound demonstrates significant inhibitory activity against both sensitive and multidrug-resistant strains of M. tuberculosis in vitro. In vivo studies indicate that CGI-17341 can prolong the survival time of infected mice in a dose-dependent manner, making it a valuable tool for research on tuberculosis and related bacterial infections.
  50. Antibacterial Agent

    Antibacterial agent 87 (Compound 4h) is a potent antibacterial compound targeting bacterial cell wall synthesis. It exhibits minimal inhibitory concentration (MIC) values of 0.125 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA), 0.0625 μg/mL against methicillin-resistant Staphylococcus epidermidis (MRSE), and 0.0625 μg/mL against Staphylococcus aureus. This reagent is suitable for research applications focused on combating antibiotic-resistant bacterial infections and studying bacterial pathogenesis.

Items 2401-2450 of 6342

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