Catalog No.
Product Name
Application
Product Information
Citations
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Metallo-β-Lactamase Inhibitor
EBL-3183 is a potent inhibitor of metallo-β-lactamases (MBLs) that targets the NDM-1 enzyme. This indole-2-carboxylate compound exhibits reversible, non-covalent, and competitive inhibition characterized by a pIC50 value of 7.7. EBL-3183 is valuable for research applications focused on combating antibiotic resistance and exploring mechanisms of MBL inhibition. -
β-lactamase Inhibitor
Xeruborbactam methoxy acetoxy methyl ester is a boronic acid derivative specifically designed as a β-lactamase inhibitor. This compound effectively inhibits the enzymatic activity of β-lactamases, which are responsible for antibiotic resistance in various bacterial strains. It is primarily utilized in research applications aimed at understanding β-lactamase mechanisms and developing novel antimicrobial therapies. -
Antibacterial Agent
Mycolic acid IIa is a key structural lipid of the mycobacterial cell wall, primarily sourced from Mycobacterium bovis BCG. This compound plays a crucial role in modulating membrane permeability and stability, making it a valuable tool for research on Mycobacterium tuberculosis infections. Its antibacterial properties support studies aimed at understanding mycobacterial pathogenesis and developing new therapeutic approaches. -
Bacterial Inhibitor
Ianthelliformisamine C ditrifluoroacetate is a bacterial inhibitor that enhances the activity of antibiotics against resistant Gram-negative bacteria. This compound has been shown to significantly improve the efficacy of doxycycline against Pseudomonas aeruginosa. Its mechanism of action involves inducing ATP efflux and causing membrane depolarization in bacterial cells. Ianthelliformisamine C ditrifluoroacetate is synthesized using peptide coupling, resulting in high chemical yields ranging from 27% to 91%, making it a valuable tool for research in combating antibiotic resistance. -
Antibacterial Agent
Ilicicolin C is an antibacterial agent with demonstrated efficacy against Pseudomonas syringae, exhibiting an IC50 of 28.5 µg/mL. Additionally, it has shown weak inhibitory effects on acetylcholinesterase and β-glucuronidase, with IC50 values ranging from 30 to 43 µg/mL. The compound also displays weak cytotoxicity in human lung fibroblasts, with IC50 values of 64 to 120 µg/mL. Furthermore, Ilicicolin C influences seed germination and root tip growth in lettuce, indicating potential implications in plant research. -
Bacterial Inhibitor
Protactin is a pentapeptide lactone that targets bacterial growth, derived from the Streptomyces cucumeris strain L703-4 (ATCC 53784). This compound demonstrates significant antioxidant properties and can be converted to actinomycin Zp through ferrocyanide oxidation, which displays potent antibacterial activity in vitro. Additionally, actinomycin Zp has been shown to possess substantial antitumor effects against P-388 leukemia in murine models, making it a valuable reagent for cancer research and microbiological studies. -
Antibacterial Agent
Olamufloxacin is an orally active fluoroquinolone antibacterial agent that exerts its effect by targeting bacterial DNA gyrase and topoisomerase IV. This compound demonstrates broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria and effectively inhibits the growth of extracellular Legionella species as well as intracellular Legionella pneumophila. Olamufloxacin also mitigates cytotoxicity associated with Legionella pneumophila and has been shown to increase survival rates and decrease lung bacterial burden in infected guinea pig models. This reagent is valuable for research focused on legionnaires’ disease and its underlying pathogenic mechanisms. -
Bacterial Inhibitor
Cyclo(Leu-Ala) is a cyclic dipeptide with demonstrated antimicrobial properties targeting bacterial pathogens. This compound exhibits significant inhibitory activity against various plant pathogens, making it a valuable tool in studies involving plant-microbe interactions and the development of novel antimicrobial agents. Its potential applications include agricultural research and the investigation of natural products for controlling plant diseases. -
Antibacterial Agent
Syringopicroside is a natural compound derived from Syringa oblata Lindl. It exhibits significant antibacterial activity, making it a valuable tool for research into microbial infections and potential therapeutic applications. This compound is of interest for studies exploring the mechanisms of action against a variety of bacterial strains. -
Bacterial Inhibitor
Haplopine is a bacterial inhibitor that exhibits photo-activated antimicrobial properties. It demonstrates the ability to bind to DNA, making it a valuable tool for research applications focused on bacterial infections and microbial resistance. This compound is beneficial in studies investigating the mechanisms of antimicrobial action and the potential development of novel therapeutic strategies. -
Antibacterial Agent
8,9-Dehydro-7,9-diisobutyryloxythymol is a derivative of thymol that exhibits antibacterial properties. This compound demonstrates selective inhibitory activity against Gram-positive bacteria, notably Bacillus cereus, while showing no detectable cytotoxicity against human cancer cell lines in vitro. 8,9-Dehydro-7,9-diisobutyryloxythymol is valuable for research applications focused on bacterial infections and developing antibacterial agents. -
Bacterial Inhibitor
Forphenicinol is a bacterial inhibitor that acts as an immunomodulator, derived from the bacterial metabolite forphenicine. It enhances the phagocytic activity of peritoneal macrophages and is effective in mitigating cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH) in murine models. Forphenicinol increases macrophage bactericidal activity against Pseudomonas aeruginosa and improves survival rates in mouse models of P. aeruginosa infection. Additionally, it demonstrates anti-tumor effects in S180 sarcoma and IMC carcinoma xenograft models, with effective dosing ranging from 0.05 to 5 mg/kg per day. -
Antibacterial Peptide
Acetyl-Adhesin (1025-1044) amide is a 20-peptide fragment derived from the cell surface adhesin of Streptococcus pyogenes, functioning as an antibacterial peptide. This compound specifically inhibits the interaction between adhesin and salivary receptors, thereby preventing the recolonization of Streptococcus pyogenes. Its potential applications include studies in microbial pathogenesis and the development of novel antimicrobial strategies. -
Antibacterial Agent
Antibacterial Agent 96 (compound 4k) is a potent antibacterial compound that targets Mycobacterium tuberculosis, demonstrating significant antitubercular activity against both drug-susceptible and multidrug-resistant strains. This agent is valuable for research applications focused on tuberculosis treatment, particularly in the face of emerging resistance. However, it is important to note that Antibacterial Agent 96 exhibits toxicity to HepG2 and Vero cell lines. -
Antibacterial Agent
3,4-Seco-mansumbinoic acid is an antibacterial agent isolated from the oleo-resin of *Commiphora molmol*. This compound demonstrates significant in vitro anti-staphylococcal activity, particularly against the multidrug-resistant strain *Staphylococcus aureus* SA-1199B, with a minimum inhibitory concentration (MIC) of 4 μg/mL. Additionally, 3,4-Seco-mansumbinoic acid shows weak potentiation of Ciprofloxacin and Tetracycline against *Salmonella enterica* serovar Typhimurium strains. This compound is valuable for research focused on multidrug-resistant bacterial infections. -
Bacterial Inhibitor
Glyasperin D is a flavonoid derived from Glycyrrhiza uralensis that demonstrates antibacterial properties, specifically as a bacterial inhibitor against Helicobacter pylori. Its biological activity suggests potential applications in research focused on bacterial infections and the development of antibacterial agents. This compound may serve as a valuable tool in studying H. pylori-related diseases and exploring flavonoid mechanisms in bacterial inhibition. -
Antibacterial Agent
LAB 149202F is an acylanilide antibacterial agent that exerts inhibitory effects on bacterial strains exhibiting formyl and phosphate resistance. This compound demonstrates significant antimicrobial activity, making it a valuable tool for research into antibiotic resistance mechanisms and the development of new therapeutic strategies. Its application in various biological assays supports the exploration of bacterial pathogenesis and antibiotic efficacy. -
Antibacterial Agent
Desethylene Ciprofloxacin hydrochloride functions as an antibacterial agent, derived from the metabolism of Ciprofloxacin. It acts primarily as a topoisomerase IV inhibitor, contributing to its antibacterial properties. This compound is suitable for research applications focused on antibacterial mechanisms and the study of bacterial resistance. -
Antibacterial Agent
Antibacterial Agent 130 is a 1,1-diarylthiogalactoside that specifically targets the lectin LecA from Pseudomonas aeruginosa. It exhibits a high affinity for LecA, with a Kd of 1 μM, demonstrating effective antibiofilm activity. Although it does not possess bactericidal properties, it is valuable for research into bacterial adhesion and biofilm formation, making it a useful tool in studies of Pseudomonas aeruginosa virulence and infection mechanisms. -
Bacterial Inhibitor
JM 1397 is a potent antibacterial agent with a primary mechanism of action against bacterial pathogens. It demonstrates significant antibacterial activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC90) of 1 μg/mL. This compound is valuable for research in antibiotic resistance and the development of new antimicrobial therapies. -
Bacterial Inhibitor
Gyramide A is a bacterial inhibitor that targets bacterial topoisomerases. It has been shown to exhibit a unique mechanism of action distinct from other topoisomerase inhibitors, highlighting its potential in studies related to bacterial resistance. Gyramide A is valuable for research applications aimed at understanding the protective effects of Qnr proteins on bacterial enzymes and developing novel antibacterial strategies. -
Antibacterial Agent
Deoxymikanolide is an orally active antibacterial agent that primarily targets catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. It enhances glycan and phosphorus metabolism, increases electrical conductivity, and elevates levels of intrabacterial reactive oxygen species (ROS) and malondialdehyde (MDA). These actions result in cell shrinkage, cytoplasmic damage, and disruption in Ralstonia solanacearum. Additionally, Deoxymikanolide demonstrates efficacy in inhibiting acetic acid-induced writhing in mice, making it a valuable tool for research on bacterial wilt. -
Antibacterial Peptide
KSL-W is a multifunctional antibacterial peptide primarily targeting immune regulation. It exhibits significant chemotactic effects on neutrophils and promotes F-actin polymerization through the Gαi protein signaling pathway. Additionally, KSL-W effectively inhibits the production of reactive oxygen species (ROS) in neutrophils. This peptide is valuable for research focused on infection control and the regulation of inflammatory processes. -
Antileishmanial Agent
PT4 is an antileishmanial agent specifically effective against cutaneous leishmaniasis. It exhibits significant activity against both Leishmania species, with IC50 values of 125.18 µM for L. amazonensis and 233.18 µM for L. braziliensis. PT4 induces a reduction in mitochondrial membrane potential and elevates reactive oxygen species production, resulting in parasite lethality. Additionally, PT4 demonstrates potent in vivo anti-inflammatory properties, making it a valuable tool for research in leishmaniasis and related inflammatory conditions. -
Antibacterial Agent
Aloe vera, a natural herbal extract, exhibits significant antibacterial activity. It is recognized for its anti-inflammatory and antioxidant properties, making it a valuable candidate for research applications in areas such as tumor biology, diabetes, bone disorders, and cardiovascular health. Its diverse biological effects support its potential use as a therapeutic agent in various biomedical studies. -
Antibacterial Agent
ROS inducer 9 is an antibacterial agent that functions by inhibiting glutathione (GSH) activity and elevating reactive oxygen species (ROS) levels. With a minimum inhibitory concentration (MIC) of 0.25 μg/mL against E. coli, it demonstrates potent antibacterial properties. Additionally, ROS inducer 9 exhibits low toxicity to erythrocytes and RAW 264.7 cells, making it suitable for various biological research applications in exploring oxidative stress responses in bacterial infections. -
Anti-bacterial Agent
Anti-MRSA agent 36 is an antibacterial compound that exhibits potent activity against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 1 μg/mL. This agent specifically targets phosphatidylglycerol (PG) in bacterial membranes, leading to compromised membrane integrity, DNA leakage, and increased reactive oxygen species (ROS) production. Characterized by low cytotoxicity and minimal hemolytic effect, Anti-MRSA agent 36 also demonstrates a reduced propensity for inducing drug resistance and good plasma stability, making it suitable for research involving skin abscess and systemic infection models. -
Antibacterial Agent
Antibacterial Agent 308 is an antibacterial compound that selectively targets bacterial membranes by binding to phosphatidylethanolamine, leading to membrane polarization disruption and increased intracellular reactive oxygen species (ROS) levels. This agent exhibits significant anti-biofilm activity against Staphylococcus aureus and demonstrates potent anti-methicillin-resistant Staphylococcus aureus (MRSA) efficacy. Its unique mechanism makes it a valuable tool for research focused on combating bacterial infections and biofilm-related challenges. -
Superoxide Anion Inhibitor
Tanzawaic acid B is a potent inhibitor of superoxide anion production, derived from the fungal source Penicillium citrinum. This compound has been demonstrated to mitigate oxidative stress by targeting superoxide radicals, making it valuable for research in oxidative damage and related pathologies. Its biological activity provides a useful tool for studying the effects of reactive oxygen species in various cellular models. -
Antileishmanial Agent
Antileishmanial agent-35 is a potent antileishmanial compound that targets Leishmania amazonensis, exhibiting an IC50 of 0.29 μM against promastigotes. This compound disrupts mitochondrial function by lowering the mitochondrial membrane potential and ATP levels, while also enhancing reactive oxygen species (ROS) production due to interference with the electron transport chain. Antileishmanial agent-35 is suitable for research focused on cutaneous leishmaniasis and its underlying mechanisms of action. -
Antibiotic
TAN-420E (Dihydroherbimycin A) is an antibiotic derived from the fermentation of Streptomyces hygroscopicus. This compound demonstrates significant cytotoxicity against P-388 and KB cancer cell lines, highlighting its potential as an anti-cancer agent. In addition, TAN-420E effectively scavenges DPPH free radicals, with an IC50 value of 1.3 μM, indicating its potential antioxidant properties. Research applications include investigations into its antimicrobial and anticancer effects. -
Glycylcycline Antibiotic
Tigecycline hydrate is a glycylcycline antibiotic characterized by its broad-spectrum antibacterial activity. It exhibits significant inhibitory effects against various bacterial strains, with a mean inhibitory concentration (MIC) of approximately 125 ng/mL for E. coli (MG1655 strain). In addition, it displays MIC50 and MIC90 values of 1 mg/L and 2 mg/L, respectively, for Acinetobacter baumannii. This compound is valuable for research applications related to antibiotic efficacy and resistance studies. -
Antibacterial Agent
3,4-Dimethoxychalcone acts as an antibacterial agent by inducing deacetylation of cytoplasmic proteins, thereby promoting autophagy flux. This compound is relevant for research applications focused on disease mechanisms related to cardiac and cancer biology, offering potential pathways for therapeutic intervention. Researchers may explore its effects on cellular processes and its role as a caloric restriction mimetic in various experimental models. -
HIV-1 RT Inhibitor
Apricitabine is a selective inhibitor of HIV-1 reverse transcriptase (RT) with a Ki value of 0.08 μM. It also exerts inhibitory effects on DNA polymerases α, β, and γ, with corresponding Ki values of 300 μM, 12 μM, and 112.25 μM. Demonstrating significant antiretroviral efficacy and favorable tolerability, Apricitabine shows a reduced potential for resistance development in patients with antiretroviral-naive HIV infection. This compound is applicable for research in the mechanisms of HIV-1 replication and antiviral drug development. -
Antibacterial Agent
BWC0977 is an antibacterial agent that primarily targets bacterial DNA replication by inhibiting DNA gyrase and topoisomerase IV. This compound demonstrates potent activity with a minimum inhibitory concentration (MIC90) ranging from 0.03 to 2 µg/mL against multi-drug resistant Gram-negative bacteria. BWC0977 is suitable for research applications involving the study of bacterial resistance mechanisms and the development of new antimicrobial strategies. -
Antibacterial Agent
BWC0977 formic is an antibacterial agent that targets bacterial DNA replication by inhibiting DNA gyrase and topoisomerase IV. It demonstrates significant antibacterial activity, with a minimum inhibitory concentration (MIC90) ranging from 0.03 to 2 µg/mL against multi-drug resistant Gram-negative bacteria. This compound is valuable for research applications focused on combating antibiotic resistance and exploring therapeutic strategies for resistant infections. -
Antibiotic
Rifaquizinone is a hybrid antibiotic that combines the mechanisms of Rifamycin and Quinolone. It effectively inhibits wild-type Staphylococcus aureus RNA polymerase, exhibiting an IC50 value of 34 nM. Rifaquizinone demonstrates potent antibacterial activity against S. aureus infections, with minimum inhibitory concentrations (MICs) ranging from 0.008 to 0.5 μg/mL across 300 clinical isolates of staphylococci and streptococci, making it a valuable tool for antibiotic research and investigation into resistance mechanisms. -
Antibiotic
Erythromycin (aspartate) is a macrolide antibiotic that exerts its effects by binding to the 50S ribosomal subunit of bacteria, inhibiting RNA-dependent protein synthesis through the blockage of transpeptidation and translocation reactions. This compound demonstrates a broad spectrum of antimicrobial activity, making it an important tool in microbiological research. Additionally, erythromycin aspartate has shown potential antitumor and neuroprotective properties, expanding its applications in various fields of biomedical research. -
Antiviral Agent
Onradivir monohydrate is an orally active antiviral agent that targets the influenza A virus RNA polymerase PB2 subunit, exhibiting an IC50 value of 0.562 nM. This compound effectively inhibits cap binding to the PB2 subunit, leading to suppression of viral replication, reduction of viral titers, and decreased RNA loads. In murine models, Onradivir monohydrate demonstrates improved survival rates in influenza A virus-infected mice and is a valuable tool for studying influenza A virus infections in research applications. -
Antibiotic
Alatrofloxacin is a fluoronaphthyridone antibiotic that serves as a proagent of Trovafloxacin. Its primary mechanism involves the inhibition of DNA synthesis in pathogenic organisms, resulting in effective antimicrobial activity. In addition to its antibacterial properties, Alatrofloxacin also exhibits immunosuppressive effects, making it relevant for research applications in studying immune responses and infectious diseases. -
HBV Inhibitor
HBV-IN-48 is a potent inhibitor of Hepatitis B Virus (HBV) with demonstrated antiviral activity. It effectively reduces viral replication in HepDE19 cells, achieving an EC50 value of 0.005 μM. Additionally, HBV-IN-48 has shown the ability to lower serum HBV DNA levels in mouse models, making it a valuable tool for studying HBV infections and potential therapeutic interventions. -
Antibiotic
Ficellomycin is a nitrogen-containing bicyclic antibiotic targeting Gram-positive bacteria, including multidrug-resistant Staphylococcus aureus. It exerts its biological activity by inducing the formation of defective 34S DNA fragments that disrupt the semi-conservative DNA replication process. These fragments are unable to integrate into larger DNA segments, ultimately hindering the assembly of a complete bacterial chromosome. Ficellomycin is valuable for research on bacterial diseases and antibiotic resistance mechanisms. -
DENV Inhibitor
DENV-IN-4 is a potent inhibitor of Dengue Virus (DENV), exhibiting an EC50 value of 4.79 µM in Vero cells with a selectivity index greater than 20.9. This compound effectively reduces the expression levels of DENV2 in a concentration-dependent manner and inhibits RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 is valuable for research applications focused on understanding DENV pathogenesis and developing antiviral therapies. -
HBV DNA Synthesis Inhibitor
LB80317 is an active metabolite of LB80380 that functions as a potent inhibitor of HBV DNA synthesis, exhibiting an EC50 of 0.5 μM. This compound demonstrates antiviral activity, making it a promising candidate for the treatment of chronic hepatitis B. Its ability to inhibit viral replication supports its potential utility in HBV research and therapeutic applications. -
Tetracycline derivatives of antibiotic
Sarecycline is a narrow-spectrum tetracycline derivative antibiotic that primarily targets bacterial protein synthesis by interfering with tRNA accommodation and stabilizing mRNA binding to the 70S ribosome. It exhibits significant anti-inflammatory activity and effectively inhibits the growth of Gram-positive bacteria, including various strains of keratobacterium acnes. Sarecycline is suitable for research applications focused on understanding moderate to severe acne and its underlying mechanisms. -
Antibacterial Agent
Antibacterial Agent 89 is a potent antibacterial compound that targets bacterial transcription processes. It exhibits significant anti-clostridial activity by inhibiting the release of cytotoxins and disrupting the β’CH-σ interaction. This compound is useful for research applications focused on bacterial pathogenesis and the development of novel antibacterial strategies. -
DNA Gyrase Inhibitor
DNA Gyrase-IN-11 is a selective inhibitor of DNA gyrase, targeting bacterial DNA replication and supercoiling mechanisms. It demonstrates a potent inhibitory effect on protein synthesis with an IC50 of 0.74 μM and effectively inhibits E. coli DNA gyrase with an IC50 of 11.9 μM. Additionally, DNA Gyrase-IN-11 possesses significant antibacterial activity against pathogens such as Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Staphylococcus aureus, with minimum inhibitory concentrations (MICs) ranging from 0.008 to 0.25 μg/mL, making it a valuable tool for antimicrobial research. -
HBV Inhibitor
HBV-IN-21 is a potent inhibitor of hepatitis B virus (HBV) DNA replication, exhibiting an IC50 of 2.2 µM. This compound demonstrates a strong interaction with the HBV core capsid protein, characterized by a dissociation constant (KD) of 60.0 μM. HBV-IN-21 is suited for research applications focused on antiviral drug development and elucidation of HBV replication mechanisms. -
DNA Synthesis/HSV/HIV-1 Inhibitor
16,16-Dimethyl prostaglandin A1 is a prostaglandin analog that primarily inhibits DNA synthesis. It demonstrates significant antiviral activity by reducing viral replication in both herpes simplex virus (HSV) and HIV-1 infection models. This compound serves as a valuable tool for research focused on cancer biology and viral pathogenesis. -
Fluoroquinolone Antibiotic
PD 124816 is an orally active fluoroquinolone antibiotic that inhibits DNA gyrase (topoisomerase IV), providing broad-spectrum antibacterial activity. It demonstrates efficacy against both Gram-positive and Gram-negative bacteria, with a minimum inhibitory concentration (MIC₉₀) of ≤ 0.06 μg/mL and an MIC₉₀ of 1 μg/mL for anaerobic bacteria such as Peptostreptococcus fragi. Additionally, PD 124816 exhibits complete bactericidal effectiveness in a mouse model of Mycobacterium leprae infection. This compound is valuable for research involving mixed infections and antibiotic resistance mechanisms.
