Catalog No.
Product Name
Application
Product Information
Citations
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Bacterial
Berninamycin A is a cyclic thiopeptide antibiotic that targets Gram-positive bacteria by inhibiting protein biosynthesis through specific binding to ribosomal subunits. Initially isolated from Streptomyces bernensis, this compound also induces the transcriptional activator TipA in Streptomyces, highlighting its role in antimicrobial research. Berninamycin A is valuable for studies involving antibiotic resistance mechanisms and the development of new antibacterial agents. -
Antibacterial Agent
Asperglaucin B is an alkylated salicylaldehyde derivative derived from the fungus Aspergillus chevalieri SQ-8, recognized for its antibacterial properties. This compound exhibits potent antibacterial activity against plant pathogens, specifically Pseudomonas syringae pv actinidae and Bacillus cereus, with a minimum inhibitory concentration (MIC) of 6.25 μM. Asperglaucin B serves as a valuable tool in research focused on plant disease control and the development of novel antibacterial agents. -
Bacterial Inhibitor
8-Epidiosbulbin E acetate is a furanoid compound derived from Dioscorea bulbifera L. It functions as a bacterial inhibitor, demonstrating broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. Additionally, it has been noted to induce liver injury in murine models, highlighting its potential impact on liver function. This compound is valuable for research involving antibiotic resistance and bacterial pathogenicity. -
Bacterial Inhibitor
FtsZ-IN-10 is a bacterial division inhibitor that targets the assembly of FtsZ, a critical protein involved in bacterial cytokinesis. By binding specifically to Bacillus subtilis FtsZ monomers, FtsZ-IN-10 disrupts their polymerization, ultimately hindering the formation of the Z ring and inhibiting cell division. This compound has demonstrated efficacy against antibiotic-resistant clinical isolates, including Staphylococcus aureus and Enterococci, making it a valuable tool in microbiological research and antibiotic development. Additionally, FtsZ-IN-10 may stimulate nucleotide-free archaeal FtsZ to form structured polymers, contributing to its versatile applications in studying bacterial growth and division mechanisms. -
Metallo-β-Lactamase Inhibitor
EBL-3183 is a potent inhibitor of metallo-β-lactamases (MBLs) that targets the NDM-1 enzyme. This indole-2-carboxylate compound exhibits reversible, non-covalent, and competitive inhibition characterized by a pIC50 value of 7.7. EBL-3183 is valuable for research applications focused on combating antibiotic resistance and exploring mechanisms of MBL inhibition. -
β-lactamase Inhibitor
Xeruborbactam methoxy acetoxy methyl ester is a boronic acid derivative specifically designed as a β-lactamase inhibitor. This compound effectively inhibits the enzymatic activity of β-lactamases, which are responsible for antibiotic resistance in various bacterial strains. It is primarily utilized in research applications aimed at understanding β-lactamase mechanisms and developing novel antimicrobial therapies. -
Antibacterial Agent
Mycolic acid IIa is a key structural lipid of the mycobacterial cell wall, primarily sourced from Mycobacterium bovis BCG. This compound plays a crucial role in modulating membrane permeability and stability, making it a valuable tool for research on Mycobacterium tuberculosis infections. Its antibacterial properties support studies aimed at understanding mycobacterial pathogenesis and developing new therapeutic approaches. -
Bacterial Inhibitor
Ianthelliformisamine C ditrifluoroacetate is a bacterial inhibitor that enhances the activity of antibiotics against resistant Gram-negative bacteria. This compound has been shown to significantly improve the efficacy of doxycycline against Pseudomonas aeruginosa. Its mechanism of action involves inducing ATP efflux and causing membrane depolarization in bacterial cells. Ianthelliformisamine C ditrifluoroacetate is synthesized using peptide coupling, resulting in high chemical yields ranging from 27% to 91%, making it a valuable tool for research in combating antibiotic resistance. -
Antibacterial Agent
Ilicicolin C is an antibacterial agent with demonstrated efficacy against Pseudomonas syringae, exhibiting an IC50 of 28.5 µg/mL. Additionally, it has shown weak inhibitory effects on acetylcholinesterase and β-glucuronidase, with IC50 values ranging from 30 to 43 µg/mL. The compound also displays weak cytotoxicity in human lung fibroblasts, with IC50 values of 64 to 120 µg/mL. Furthermore, Ilicicolin C influences seed germination and root tip growth in lettuce, indicating potential implications in plant research. -
Bacterial Inhibitor
Protactin is a pentapeptide lactone that targets bacterial growth, derived from the Streptomyces cucumeris strain L703-4 (ATCC 53784). This compound demonstrates significant antioxidant properties and can be converted to actinomycin Zp through ferrocyanide oxidation, which displays potent antibacterial activity in vitro. Additionally, actinomycin Zp has been shown to possess substantial antitumor effects against P-388 leukemia in murine models, making it a valuable reagent for cancer research and microbiological studies. -
Antibacterial Agent
Olamufloxacin is an orally active fluoroquinolone antibacterial agent that exerts its effect by targeting bacterial DNA gyrase and topoisomerase IV. This compound demonstrates broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria and effectively inhibits the growth of extracellular Legionella species as well as intracellular Legionella pneumophila. Olamufloxacin also mitigates cytotoxicity associated with Legionella pneumophila and has been shown to increase survival rates and decrease lung bacterial burden in infected guinea pig models. This reagent is valuable for research focused on legionnaires’ disease and its underlying pathogenic mechanisms. -
Bacterial Inhibitor
Cyclo(Leu-Ala) is a cyclic dipeptide with demonstrated antimicrobial properties targeting bacterial pathogens. This compound exhibits significant inhibitory activity against various plant pathogens, making it a valuable tool in studies involving plant-microbe interactions and the development of novel antimicrobial agents. Its potential applications include agricultural research and the investigation of natural products for controlling plant diseases. -
Antibacterial Agent
Syringopicroside is a natural compound derived from Syringa oblata Lindl. It exhibits significant antibacterial activity, making it a valuable tool for research into microbial infections and potential therapeutic applications. This compound is of interest for studies exploring the mechanisms of action against a variety of bacterial strains. -
Bacterial Inhibitor
Haplopine is a bacterial inhibitor that exhibits photo-activated antimicrobial properties. It demonstrates the ability to bind to DNA, making it a valuable tool for research applications focused on bacterial infections and microbial resistance. This compound is beneficial in studies investigating the mechanisms of antimicrobial action and the potential development of novel therapeutic strategies. -
Antibacterial Agent
8,9-Dehydro-7,9-diisobutyryloxythymol is a derivative of thymol that exhibits antibacterial properties. This compound demonstrates selective inhibitory activity against Gram-positive bacteria, notably Bacillus cereus, while showing no detectable cytotoxicity against human cancer cell lines in vitro. 8,9-Dehydro-7,9-diisobutyryloxythymol is valuable for research applications focused on bacterial infections and developing antibacterial agents. -
Bacterial Inhibitor
Forphenicinol is a bacterial inhibitor that acts as an immunomodulator, derived from the bacterial metabolite forphenicine. It enhances the phagocytic activity of peritoneal macrophages and is effective in mitigating cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH) in murine models. Forphenicinol increases macrophage bactericidal activity against Pseudomonas aeruginosa and improves survival rates in mouse models of P. aeruginosa infection. Additionally, it demonstrates anti-tumor effects in S180 sarcoma and IMC carcinoma xenograft models, with effective dosing ranging from 0.05 to 5 mg/kg per day. -
Antibacterial Peptide
Acetyl-Adhesin (1025-1044) amide is a 20-peptide fragment derived from the cell surface adhesin of Streptococcus pyogenes, functioning as an antibacterial peptide. This compound specifically inhibits the interaction between adhesin and salivary receptors, thereby preventing the recolonization of Streptococcus pyogenes. Its potential applications include studies in microbial pathogenesis and the development of novel antimicrobial strategies. -
Antibacterial Agent
Antibacterial Agent 96 (compound 4k) is a potent antibacterial compound that targets Mycobacterium tuberculosis, demonstrating significant antitubercular activity against both drug-susceptible and multidrug-resistant strains. This agent is valuable for research applications focused on tuberculosis treatment, particularly in the face of emerging resistance. However, it is important to note that Antibacterial Agent 96 exhibits toxicity to HepG2 and Vero cell lines. -
Antibacterial Agent
3,4-Seco-mansumbinoic acid is an antibacterial agent isolated from the oleo-resin of *Commiphora molmol*. This compound demonstrates significant in vitro anti-staphylococcal activity, particularly against the multidrug-resistant strain *Staphylococcus aureus* SA-1199B, with a minimum inhibitory concentration (MIC) of 4 μg/mL. Additionally, 3,4-Seco-mansumbinoic acid shows weak potentiation of Ciprofloxacin and Tetracycline against *Salmonella enterica* serovar Typhimurium strains. This compound is valuable for research focused on multidrug-resistant bacterial infections. -
Bacterial Inhibitor
Glyasperin D is a flavonoid derived from Glycyrrhiza uralensis that demonstrates antibacterial properties, specifically as a bacterial inhibitor against Helicobacter pylori. Its biological activity suggests potential applications in research focused on bacterial infections and the development of antibacterial agents. This compound may serve as a valuable tool in studying H. pylori-related diseases and exploring flavonoid mechanisms in bacterial inhibition. -
Antibacterial Agent
LAB 149202F is an acylanilide antibacterial agent that exerts inhibitory effects on bacterial strains exhibiting formyl and phosphate resistance. This compound demonstrates significant antimicrobial activity, making it a valuable tool for research into antibiotic resistance mechanisms and the development of new therapeutic strategies. Its application in various biological assays supports the exploration of bacterial pathogenesis and antibiotic efficacy. -
Antibacterial Agent
Desethylene Ciprofloxacin hydrochloride functions as an antibacterial agent, derived from the metabolism of Ciprofloxacin. It acts primarily as a topoisomerase IV inhibitor, contributing to its antibacterial properties. This compound is suitable for research applications focused on antibacterial mechanisms and the study of bacterial resistance. -
Antibacterial Agent
Antibacterial Agent 130 is a 1,1-diarylthiogalactoside that specifically targets the lectin LecA from Pseudomonas aeruginosa. It exhibits a high affinity for LecA, with a Kd of 1 μM, demonstrating effective antibiofilm activity. Although it does not possess bactericidal properties, it is valuable for research into bacterial adhesion and biofilm formation, making it a useful tool in studies of Pseudomonas aeruginosa virulence and infection mechanisms. -
Bacterial Inhibitor
JM 1397 is a potent antibacterial agent with a primary mechanism of action against bacterial pathogens. It demonstrates significant antibacterial activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC90) of 1 μg/mL. This compound is valuable for research in antibiotic resistance and the development of new antimicrobial therapies. -
Bacterial Inhibitor
Gyramide A is a bacterial inhibitor that targets bacterial topoisomerases. It has been shown to exhibit a unique mechanism of action distinct from other topoisomerase inhibitors, highlighting its potential in studies related to bacterial resistance. Gyramide A is valuable for research applications aimed at understanding the protective effects of Qnr proteins on bacterial enzymes and developing novel antibacterial strategies. -
Antibacterial Agent
Vaneprim is an antibacterial agent that exhibits broad-spectrum activity against various bacterial strains. Its mechanism involves the inhibition of bacterial cell wall synthesis, leading to cell lysis and death. This reagent is valuable for research applications involving the study of bacterial resistance mechanisms and the development of new antibacterial therapies. -
Antibacterial Agent
Chinenol A is an antibacterial agent derived from the aerial parts of Helwingia chinensis. It exhibits significant activity against various bacterial strains, including Staphylococcus aureus, Mycobacterium tuberculosis, and Streptococcus pneumoniae. This compound is valuable for research focused on bacterial infections and developing therapeutic strategies against resistant bacterial pathogens. -
Antibacterial Agent
Apigravin is a potent antibacterial agent primarily targeting Gram-positive bacteria. It exhibits significant antibacterial activity against Bacillus subtilis, with a minimum inhibitory concentration (MIC) of 61 μM. This compound is valuable for research applications focused on studying bacterial infections and evaluating potential therapeutic agents against multidrug-resistant strains. -
Macrolide Compound
Sch725674 is a macrolide compound known for its antimicrobial properties, particularly against brewer's yeast and Candida albicans. The compound exhibits minimum inhibitory concentrations (MICs) of 8 μg/ml and 32 μg/ml, respectively. Its biological activity makes it suitable for research applications focused on antifungal mechanisms and the development of new antimicrobial strategies. -
Antibacterial
UCM53 is a potent FtsZ inhibitor with significant antibacterial properties. It effectively inhibits the growth of clinical isolates of antibiotic-resistant Staphylococcus aureus and Enterococcus faecalis. This compound is suitable for research applications involving studies on bacterial cell division and the development of novel antibacterial agents. -
Bacterial Inhibitor
Acorafloxacin hydrochloride is a broad-spectrum fluoroquinolone antibacterial agent that targets bacterial DNA gyrase and topoisomerase IV. It exhibits potent activity against a range of Gram-positive bacteria, with a mean MIC90 value of 0.12 mg/L. This compound is particularly relevant for research on acute bacterial skin infections and community-acquired pneumonia, as well as the investigation of methicillin-resistant Staphylococcus aureus (MRSA) infections. -
Anti-Bacterial Agent
Norchelerythrine is an alkaloid derived from the roots of Zanthoxylum capense, exhibiting significant antibacterial properties. It demonstrates inhibitory activity against a range of bacteria, including Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, and Escherichia coli, with MIC values exceeding 50 µg/mL. This compound is valuable for research applications focused on evaluating antibacterial mechanisms and developing new therapeutic agents against bacterial infections. -
Antibacterial Agent
Nervogenic acid is an aromatic compound with demonstrated antibacterial properties, isolated from Piper elongatum VAHL. It exhibits significant antibacterial activity, making it a valuable reagent for research in microbiology and the development of antimicrobial therapies. Additionally, nervogenic acid offers antioxidative effects, suggesting its potential applications in studies related to oxidative stress and cellular health. -
Bacterial Inhibitor
Targeting the bacterial sliding clamp peptide 46 is a short peptide designed to inhibit the bacterial sliding clamp (SC). By interfering with SC-dependent DNA synthesis, this peptide serves as a valuable tool for studying bacterial replication mechanisms and developing novel antibacterial strategies. Its application in research underscores its potential utility in exploring bacterial growth and resistance pathways. -
Quinolone Broad-Spectrum Antibacterial Agent
PD 140248 hydrochloride is a quinolone broad-spectrum antibacterial agent that exhibits potent bacteriostatic activity, particularly against Gram-positive bacteria. This compound is valuable for in vitro studies aimed at investigating bacterial susceptibility and the mechanisms of antibacterial resistance. Its efficacy in inhibiting Gram-positive pathogens makes it a useful tool for microbiological research and antibiotic development efforts. -
Antibacterial Agent
Antibacterial agent 97 is a potent antibacterial compound with a primary mechanism of inhibiting bacterial growth. It demonstrates significant antibacterial activity, exhibiting minimum inhibitory concentrations (MIC) of 16 µg/mL against both Escherichia coli and Staphylococcus aureus. This compound is applicable in various research settings focused on understanding bacterial resistance and evaluating new antibacterial therapies. -
Bacterial Metabolite
Herbimycin C is a bacterial metabolite derived from Streptomyces hygroscopicus. It exhibits significant cytotoxicity against HeLa and Ehrlich cells, with IC50 values of 7.3 µg/mL and 1.2 µg/mL, respectively. This compound is primarily utilized in cancer research to investigate its potential therapeutic applications and mechanisms of action against tumor cells. -
Antibacterial
Ocotillone (24S)-20,24-Epoxy-25-hydroxydammaran-3-one) is a triterpenoid compound derived from the fruits of Dysoxylum richii. This compound exhibits significant antibacterial activity against pathogens such as Pseudomonas aeruginosa and Salmonella typhimurium, while demonstrating no hemolytic activity. Ocotillone is valuable for research applications focused on antibacterial drug development and the exploration of natural antimicrobial agents. -
Bacterial Growth Substrate
Di-aspartic acid (Aspartylaspartate) serves as a growth substrate for several bacterial species, including Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, and Fusobacterium nucleatum. Its ability to support the growth of these bacteria makes it a valuable tool in microbiological research, particularly in studies related to periodontal disease and oral microbiome dynamics. -
β-lactamase Inhibitor
Pralurbactam is a potent β-lactamase inhibitor that enhances the antibacterial efficacy of Imipenem against Mycobacterium abscessus. Its ability to reduce pulmonary bacterial load in neutropenic mice highlights its potential as a significant therapeutic agent. This compound is valuable in research focused on infections caused by Mycobacterium abscessus complex, as well as strains of Escherichia coli and Klebsiella pneumoniae. -
Antibacterial Agent
Antibacterial Agent 34 is a potent antibacterial compound that enhances the efficacy of Ceftazidime by significantly reducing its minimum inhibitory concentration (MIC) value. This compound exhibits broad-spectrum antibacterial activity and serves as a valuable tool in research applications focused on overcoming antibiotic resistance and improving antibacterial therapies. Its mechanism of action may provide insights into the synergistic effects of antibiotic combinations in combating infectious diseases. -
Antibacterial
Camaric acid is a natural compound with notable antibacterial activity, isolated from the root of Lantana montevidensis. It demonstrates potential in inhibiting bacterial growth, making it a valuable reagent for research into antimicrobial agents and the development of therapeutic alternatives to conventional antibiotics. This compound can be utilized in various biological assays aimed at exploring its effects on bacterial pathogens. -
Antibacterial Agent
Asperglaucin A is a phthalide-like derivative known for its antibacterial activity. It demonstrates potent efficacy against plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with a minimum inhibitory concentration (MIC) of 6.25 μM. This compound is useful in research applications aimed at understanding antibacterial mechanisms and developing novel antimicrobial strategies. -
Bacterial
L-leucyldoxorubicin (Leurubicin) is a potent topoisomerase II inhibitor targeting bacterial cells. This compound exhibits significant antibacterial activity, making it a valuable tool for investigating bacterial infections and developing novel therapeutic strategies. Researchers can leverage its mechanism of action to explore the role of DNA topology in bacterial resistance and susceptibility. -
Antibacterial Agent
Glicophenone is an antibacterial agent that exhibits activity against various strains of Staphylococcus aureus, including MRSA and MSSA, with minimum inhibitory concentrations (MICs) of 32 μg/mL. This compound is useful in research applications focused on combating multidrug-resistant bacterial infections. Its efficacy against both methicillin-resistant and methicillin-sensitive strains makes it a valuable tool for studying bacterial resistance mechanisms. -
Antibacterial Peptide
Eumenitin is an antibacterial peptide targeting bacterial membranes, exhibiting broad-spectrum activity against both Gram-positive and Gram-negative bacteria with minimal hemolytic toxicity. It effectively induces the release of β-hexosaminidase from rat peritoneal mast cells and RBL-2H3 cells. Eumenitin is valuable for research into infectious diseases and the mechanisms of antibacterial action. -
Antibacterial Agent
Isovalerylspiramycin II is an antibacterial agent that exhibits potent activity against a variety of bacterial strains. As a primary component of the multi-component antibiotic Bitespiramycin, it plays a critical role in the study of bacterial infections. This reagent is useful in research applications aimed at understanding antibacterial mechanisms and developing new therapeutic strategies. -
Antibacterial Peptide
Oncocin is an antibacterial peptide belonging to the proline-rich antimicrobial peptide (PrAMP) class. It exhibits potent activity against Gram-negative bacteria, with minimal inhibitory concentrations (MIC) ranging from 0.125 to 8 μg/mL against various strains and clinical isolates of Enterobacteriaceae and non-fermenters. Oncocin targets the substrate-binding domain of the chaperone DnaK, leading to protein misfolding and aggregation, ultimately resulting in bacterial cell death. This mechanism makes Oncocin valuable for research into bacterial resistance and antimicrobial therapies. -
Antibacterial Drug
Xibornol is an antibacterial agent that exhibits potent activity against Gram-positive bacteria, including Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, as well as Actinomyces israelii and Corynebacterium ulcerans. This compound is especially relevant for applications in oral antisepsis and as an adjunctive treatment for pharyngeal infections caused by these microorganisms. Its effectiveness in targeting harmful bacterial strains makes Xibornol a valuable resource in antibacterial research and therapeutic development. -
Antibacterial Agents
(E)-3,4-Dimethoxychalcone acts as an antibacterial agent through its interaction with microbial cellular mechanisms. This compound exhibits significant antimicrobial and antioxidant properties, making it valuable in research applications focused on infection control and oxidative stress studies. Its isoform status enhances the understanding of structure-activity relationships in antimicrobial development.
