Catalog No.
Product Name
Application
Product Information
Citations
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Sulfaquinoxaline is a veterinary antimicrobial agent effective against a broad spectrum of Gram-negative and Gram-positive bacteria. It is commonly used for the prevention and treatment of coccidiosis and bacterial infections in livestock and poultry.
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NS3-NS4B interaction inhibitor
(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor that targets the NS3–NS4B protein interaction. It demonstrates nanomolar to picomolar antiviral activity across a panel of 21 clinical dengue virus isolates. With a favorable pharmacokinetic profile, (+)-JNJ-A07 exhibits exceptional efficacy in mouse models of dengue virus infection, making it a strong candidate for antiviral research and therapeutic development. -
Hsp90/HSV inhibitor
AT-533 is a potent inhibitor of heat shock protein 90 (Hsp90) and herpes simplex virus (HSV), exhibiting strong antitumor and antiviral activities. It suppresses tumor growth and angiogenesis by disrupting the HIF-1α/VEGF/VEGFR-2 signaling axis, a critical pathway in tumor vascularization and progression. Additionally, AT-533 inhibits key downstream signaling cascades, including Akt/mTOR/p70S6K, ERK1/2, and FAK pathways. In endothelial cells, specifically human umbilical vein endothelial cells (HUVECs), AT-533 effectively inhibits tube formation, cell migration, and invasion, highlighting its anti-angiogenic properties. These combined effects position AT-533 as a promising candidate for cancer therapy and angiogenesis-related disease research. -
HIV-1 protease/PTP1B inhibitor
Isosinensetin is a bioactive flavonoid compound with diverse pharmacological properties. It acts as a dual inhibitor of HIV-1 protease and protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 2.61 µM and a Kᵢ of 0.92 µM for PTP1B, indicating its potential in antiviral and metabolic disease research. Additionally, isosinensetin inhibits P-glycoprotein (P-gp) activity in MDR1-MDCKII cells, suggesting its utility in overcoming multidrug resistance. Isosinensetin exhibits multiple therapeutic effects, including anti-tumor, anti-viral, anti-inflammatory, and antioxidant activities. These properties support its application in the research of various conditions such as cancer, chronic inflammation, osteoporosis, diabetes, and infectious diseases. -
glutamine amidotransferase inhibitor
Azaserine (CI-337) is a glutamine analog and competitive inhibitor of glutamine amidotransferase, an enzyme involved in nucleotide biosynthesis. It exhibits both antibiotic and antitumor properties by disrupting glutamine-dependent metabolic processes essential for cell proliferation. Azaserine demonstrates antibacterial activity and has shown antitumor effects in various cancer models. However, it has also been reported to possess tumorigenic potential under certain conditions, warranting cautious evaluation. -
Innate defense regulator
Dusquetide (SGX-942, SGX94) is a synthetic 5-amino acid peptide and innate defense regulator (IDR) with immunomodulatory, anti-inflammatory, anti-infective, and anti-mucositis properties. Upon intravenous administration, it binds to the ZZ domain of sequestosome-1 (p62), activating key signaling pathways such as MAPK p38 and C/EBP involved in innate immune regulation. Dusquetide is a promising agent for modulating immune responses in various inflammatory and infectious conditions. -
Glucosinolate
Sinigrin, a glucosinolate primarily found in cruciferous vegetables, exhibits significant biological activities including anti-cancer, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, along with the inhibition of fat synthesis. This compound is of particular interest in cancer research, as well as studies focused on inflammatory and metabolic diseases. Its diverse therapeutic potential makes it a valuable reagent for exploring various biological pathways. -
Antibacterial Agent
Deoxyshikonin is an antibacterial agent that exhibits significant activity against methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae, with a minimum inhibitory concentration (MIC) of 17 μg/mL. It enhances the expression of VEGF-C and VEGF-A mRNA in human microvascular endothelial cells, promotes the interaction of HIF-1α and HIF-1β subunits, and binds to specific DNA sequences associated with HIF. Additionally, Deoxyshikonin demonstrates proangiogenic and antitumor effects by inhibiting colorectal cancer via the PI3K/Akt/mTOR signaling pathway, making it valuable for both antibacterial and cancer research applications. -
Influenza Virus Inhibitor
Dehydroandrographolide succinate acts as a potent inhibitor of the influenza virus. Extracted from the medicinal plant Andrographis paniculata, it exhibits immunostimulatory, anti-infective, and anti-inflammatory properties, making it valuable for research into viral pneumonia and upper respiratory tract infections. Additionally, it demonstrates antithrombotic effects by significantly reducing platelet aggregation, as evidenced by a calculated ED50 of 386.9 mg/kg. The compound also mitigates muscle atrophy through the Akt/GSK3β and MuRF-1 signaling pathways. -
Glucosinolate
Sinigrin hydrate is an allyl-glucosinolate known for its diverse biological activities, primarily targeting glucosinolate pathways. This compound exhibits anti-cancer, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, as well as the ability to inhibit fat synthesis. Sinigrin hydrate is valuable for research into tumor biology, inflammatory processes, and metabolic disorders. -
Antibiotic
Chrysomycin A is an antibiotic derived from the Streptomyces genus. It demonstrates significant antitumor properties, alongside effective activity against Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus (MRSA). In glioblastoma research, Chrysomycin A has been shown to inhibit cancer cell proliferation, migration, and invasion by targeting the Akt/GSK-3β/β-catenin signaling pathway, making it a valuable tool for cancer studies and antibiotic research. -
Furofuran Type Lignan
(+)-Medioresinol is a furofuran-type lignan that exhibits notable antifungal and antibacterial activities. It enhances the efficacy of antibiotics through its antimicrobial and antibiofilm properties and promotes intracellular reactive oxygen species (ROS) accumulation, leading to mitochondrial-mediated apoptosis in Candida albicans. Additionally, (+)-Medioresinol inhibits LPS-stimulated IL-12p40 production and acts as a PGC-1α activator, providing protection against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. This compound is valuable for research into fungal and bacterial infections, inflammatory responses, and ischemic stroke mechanisms. -
GPI/NS2B-NS3/CK1ε Inhibitor
Rhodiolin is a flavonoid that acts as a GPI (glucose 6-phosphate isomerase) and NS2B-NS3 protease inhibitor, with significant implications for cancer and viral research. It demonstrates the ability to inhibit glycolysis in papillary thyroid cancer, leading to suppressed PI3K/AKT/mTOR signaling and induced apoptosis. Additionally, Rhodiolin disrupts dengue viral replication through its action on the NS2B-NS3 protease. With its potential to inhibit CK1ε kinase, it serves as a valuable candidate for developing anticancer strategies and investigating anti-tumor and antiviral mechanisms. -
Fungicide
Triadimefon is an orally active fungicide targeting various fungal species. It has been shown to significantly reduce the phosphorylation of AKT1 and ERK1/2, while increasing levels of phosphorylated AMPK without affecting total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis impacting testosterone synthesis, and affects fetal adrenal development in rodent models. Additionally, it induces metabolic alterations in hepatocytes and impairs spatial learning and memory. -
Bacterial Inhibitor
Vasicine, a quinazoline alkaloid derived from Justicia adhatoda, primarily targets bacterial strains as an inhibitor. This compound is known to activate the PI3K/Akt signaling pathway and demonstrates significant antioxidant and anti-inflammatory activities. Its unique biological profile makes Vasicine valuable for research in microbial resistance and inflammation-related studies. -
Bacterial Inhibitor
Vasicine hydrochloride, a quinazoline alkaloid derived from Justicia adhatoda, acts primarily as a bacterial inhibitor. It activates the PI3K/Akt signaling pathway and demonstrates significant antioxidant and anti-inflammatory properties. This compound is valuable for research involving antimicrobial activity and cellular signaling pathways, making it a useful tool for studies in infectious disease and inflammation. -
Antibacterial Agent
Canthin-6-one is an indole alkaloid that serves as an effective antibacterial agent. Its primary mechanism involves the inhibition of bacterial growth, making it valuable for research in antimicrobial applications. Additionally, Canthin-6-one exhibits anti-inflammatory properties, suggesting potential in studies related to inflammation. -
Anthocyanin Compound
Cyanidin 3-sambubioside chloride is an anthocyanin compound noted for its ability to inhibit nitric oxide and angiotensin-converting enzyme (ACE) activity. It demonstrates significant antiviral properties, specifically inhibiting influenza neuraminidase with an IC50 of 72 μM and serves as a potent H274Y mutation inhibitor. Additionally, this compound exhibits antioxidant and anti-angiogenic activities, making it suitable for various biological and pharmaceutical research applications. -
Androgen/HSV-1 Inhibitor
Brassicasterol is a metabolite of Ergosterol that primarily targets androgen pathways and exhibits antiviral activity against HSV-1. It demonstrates significant anticancer potential in prostate cancer by dual modulation of AKT and androgen receptor signaling pathways. Additionally, Brassicasterol inhibits sterol δ 24-reductase, contributing to the slowdown of atherosclerosis progression. Furthermore, it serves as a cerebrospinal fluid biomarker for Alzheimer's disease, highlighting its relevance in neurodegenerative research. -
Bacterial Inhibitor
Bavachalcone is a bacterial inhibitor known for its multifaceted biological activities. It induces apoptosis and enhances autophagy in HepG2 cancer cells, contributing to its anticancer potential. Additionally, Bavachalcone demonstrates anti-neuroinflammatory and antidepressant effects through modulation of the NF-κB pathway. It also inhibits osteoclast differentiation by interfering with ERK and Akt signaling pathways, as well as the expression of c-Fos and NFATc1, and shows a significant inhibitory effect on BACE-1 activity in vitro. -
NA Inhibitor
Urolithin M5 is an orally active inhibitor of influenza virus neuraminidase, exhibiting IC50 values of approximately 174.8 μM to 257.1 μM. It effectively suppresses influenza virus replication, including strains resistant to oseltamivir, while demonstrating neuroprotective properties by reducing reactive oxygen species and inhibiting neuronal apoptosis. Urolithin M5 also promotes neurite outgrowth and protects against lung edema in infected mammals. Additionally, it interacts with key signaling proteins such as IGF1R, MAPK14, AKT1, NFKB1, and EGFR, making it a valuable reagent for research into influenza and neurodegenerative diseases like Alzheimer's. -
HBV Inhibitor
Isoscopoletin, also known as 6-Hydroxy-7-methoxycoumarin, primarily inhibits hepatitis B virus (HBV) replication. It demonstrates significant cytotoxic effects against human CCRF-CEM leukaemia cells and their multidrug-resistant subline, with IC50 values of 4.0 μM and 1.6 μM, respectively. Additionally, Isoscopoletin exhibits anti-inflammatory properties by modulating the MAPK/NF-κB/STAT/AKT signaling pathways, making it a valuable compound for research in virology and cancer biology. -
IL-6 Inhibitor
Koaburaside is an IL-6 inhibitor known for its cytoprotective and anti-inflammatory properties. This natural compound exhibits significant antioxidant activity, with an IC50 value of 9.0 μM in the DPPH free radical scavenging assay. Additionally, Koaburaside effectively reduces histamine release and downregulates the expression of pro-inflammatory cytokines IL-6 and TNF-α in human mast cells. It also demonstrates inhibitory effects on influenza A neuraminidase, highlighting its potential applications in inflammatory and viral research. -
Iron Chelator
Desferricoprogen is a hydrophobic fungal iron chelator that targets iron metabolism. It has been shown to reduce atherosclerotic plaque formation and inhibit lipid peroxidation in the aortic roots of ApoE−/− mice on an atherogenic diet. Additionally, Desferricoprogen effectively lowers levels of oxidized LDL (oxLDL) and inhibits the expression of oxLDL-induced genes such as HO-1, CD36, and TNF-α. Furthermore, it prevents TNF-α-induced endothelial cell activation and maintains endothelial monolayer integrity, making it a valuable tool for research on atherosclerosis. -
Anti-inflammatory Agent
Lucidone is an anti-inflammatory agent derived from the fruit of Lindera erythrocarpa Makino. It effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 mouse macrophages, while also reducing tumor necrosis factor-alpha (TNF-α) secretion and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, Lucidone prevents the translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and inhibits signaling pathways mediated by c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK). It also exhibits inhibitory activity against the Dengue virus (DENV), with an EC50 value of 25 μM. -
Antibiotic
Ceftiofur sodium is an antibiotic that acts as a cell wall synthesis inhibitor by targeting bacterial penicillin-binding proteins (PBPs). It exhibits bactericidal activity through the inhibition of peptidoglycan synthesis, resulting in bacterial cell lysis. Additionally, Ceftiofur sodium has anti-inflammatory properties by inhibiting the activation of NF-κB and MAPKs, which decreases the secretion of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6. This compound is applicable in research related to antibiotic resistance and inflammatory responses. -
EV71 Inhibitor
Mosloflavone is a flavonoid derived from Scutellaria baicalensis Georgi, exhibiting inhibitory activity against Enterovirus 71 (EV71). It targets the VP2 protein, preventing viral replication and inhibiting the synthesis of viral capsid proteins during the early stages of infection. Additionally, Mosloflavone demonstrates biocidal properties by inhibiting Pseudomonas aeruginosa virulence and biofilm formation, making it a valuable tool for research in virology and microbiology. -
Antibacterial Agent
Desfuroylceftiofur is an antibacterial agent and the predominant microbiologically active metabolite of ceftiofur, retaining an intact β-lactam ring. This compound exhibits in vitro activity against a range of Gram-negative and Gram-positive veterinary pathogens, including common equine pathogens. Desfuroylceftiofur is suitable for research applications focused on respiratory infections in veterinary medicine. -
HIV-1 Entry Inhibitor
Trilobatin is a natural sweetener extracted from Lithocarpus polystachyus Rehd, functioning primarily as an HIV-1 entry inhibitor by targeting the HIV-1 Gp41 envelope protein. It demonstrates neuroprotective effects and acts as a selective SGLT1/2 inhibitor, promoting the proliferation of human hepatoblastoma cells. Trilobatin is valuable for research involving HIV-1 entry mechanisms and potential therapeutic applications in hepatoblastoma and neuroprotection studies. -
Bacterial Inhibitor
Lysozyme, also known as Muramidase, is a conserved antimicrobial protein that targets bacterial cell wall peptidoglycan (PG). It exerts a bactericidal effect by hydrolyzing PG, thereby limiting bacterial growth on mucosal surfaces and controlling potential pathogens while preventing dysbiosis through microbiota regulation. Additionally, extracellular lysozyme degrades polymeric PG into soluble fragments, activating NOD receptors in mucosal epithelial cells and stimulating the secretion of chemokines and activating factors by neutrophils and macrophages. This makes lysozyme a valuable reagent for studies involving antimicrobial activity, immune response, and microbiome research. -
Bacterial Inhibitor
Ciclopirox olamine is a synthetic antifungal agent primarily targeting various fungal pathogens. It exhibits a broad spectrum of activity against dermatophytes, yeasts, molds, and multiple Gram-positive and Gram-negative bacteria. In addition to its antibacterial properties, Ciclopirox olamine has demonstrated anticancer and anti-inflammatory effects, making it a valuable reagent for research in superficial mycoses, cancer biology, and inflammation studies. -
Fungicide
Kresoxim-methyl is a Strobilurin-based fungicide that primarily targets the cytochrome bc1 complex, inhibiting respiration at complex III. It demonstrates high affinity binding to yeast complex III with an apparent Kd of 0.07 μM. This compound is widely utilized in agricultural research to assess its antifungal activity and its mechanisms in pathogen resistance management. -
jRdRp Inhibitopr
Kulactone is a natural bioflavonoid that functions as an inhibitor of the RNA-dependent RNA polymerase (jRdRp). This compound demonstrates significant antifungal, antibacterial, and antiplasmodial activities, making it a valuable tool in infectious disease research. Additionally, Kulactone is noted for its inability to cross the blood-brain barrier, which may limit its central nervous system effects and enhance its application in peripheral infections. -
Fungicide
Dimethomorph is a fungicide classified as a sterol biosynthesis inhibitor. It effectively disrupts fungal cell wall formation, thereby impeding fungal growth. Additionally, Dimethomorph has been shown to inhibit androgen receptor (AR) activity in MDA-kb2 cells with an IC20 value of 0.263 µM, making it relevant for studies on hormone receptor signaling and fungal pathogenesis. -
Antifungal Agent
D75-4590 is a pyridobenzimidazole derivative that functions as a β-1,6-glucan synthesis inhibitor. This compound exhibits significant antifungal activity, making it a valuable tool for investigating fungal biology and potential therapeutic applications. Its mechanism of action may aid in the development of novel antifungal strategies and enhance understanding of cell wall biosynthesis in pathogenic fungi. -
Antifungal Agent
1-Eicosanol, a long-chain fatty alcohol, functions as an antifungal agent by inhibiting mycelial growth of pathogens such as Alternaria solani and Botrytis cinerea. Derived from natural sources including the leaves of Leea indica and produced by Bacillus velezensis ZJ1, this compound is particularly relevant for research focused on tomato early blight and gray mold. Its applications extend to understanding fungal interactions and exploring biocontrol methods in agricultural settings. -
Fungicide Agent
Faltan is a dicarboximide fungicide that primarily targets fungal pathogens to inhibit their growth. It is commonly employed in the agricultural industry for the protection of vines and various vegetable crops. Additionally, Faltan exhibits cytotoxic effects on human bronchial epithelial cells, making it a valuable compound for research in both plant protection and cellular biology applications. -
Fungicide
Isoprothiolane is a potent blast fungicide that targets fungal growth during the penetration and development phases of infecting hyphae. It exhibits antifungal and anti-inflammatory properties, making it suitable for various agricultural applications. Additionally, Isoprothiolane has been shown to modulate lipid metabolism by reducing serum phospholipid and total lipid concentrations, contributing to research in fatty liver conditions. Its versatile biological activities support its use in both plant protection and metabolic studies. -
Antibiotic
Roridin E is an antibiotic that exhibits cell-inhibiting and fungicidal properties. It is known for its efficacy in combating various fungal infections and serves as a valuable tool in antimicrobial research. Roridin E's mechanism of action, which involves disrupting cellular processes in target organisms, makes it suitable for studies aimed at understanding fungal pathogenesis and potential therapeutic interventions. -
Fungicide
Flutriafol is a triazole fungicide that inhibits the enzyme lanosterol 14α-demethylase, disrupting ergosterol biosynthesis in fungal cell membranes. It exhibits broad-spectrum antifungal activity, making it effective against various plant pathogens. Flutriafol is commonly utilized in agricultural research and crop protection studies to manage fungal diseases and enhance plant health. -
antifungal agent
Abafungin is an antifungal agent that functions by inhibiting the transmethylation at the C-24 position of the sterol side chain, a reaction catalyzed by the enzyme sterol-C-24-methyltransferase. This mechanistic action disrupts ergosterol biosynthesis, which is crucial for fungal cell membrane integrity. Abafungin is used in research to study fungal pathogenesis and to develop new antifungal therapies. -
Antifungal Agent
6-Chloro-7-deazapurine-β-D-riboside functions as an antifungal agent through its nucleoside derivative structure. It demonstrates inhibitory activity against various plant pathogenic fungi, making it a valuable tool for studies in fungal biology and plant protection. This compound may be utilized in research focused on antifungal mechanisms and the development of novel therapeutic strategies in agriculture. -
Antifungal Antibiotic Agent
Candicidin is a polyene antifungal antibiotic agent that functions by binding to ergosterol in fungal cell membranes, leading to increased permeability and cell death. It exhibits potent antifungal activity against a range of pathogenic fungi. Candicidin is primarily used in research applications focused on fungal infections and the mechanisms of antifungal resistance. -
Fungicide
Quinoxyfen is a systemic fungicide that primarily targets the growth and development of powdery mildew pathogens. It exhibits significant antifungal activity by inhibiting the biosynthesis of sterols, which are essential for fungal cell membrane integrity. Quinoxyfen is widely utilized in agricultural research for its effectiveness in controlling powdery mildew in various crops, making it an important agent in plant disease management studies. -
Antibiotic
Polyhexamethyleneguanidine hydrochloride is a cationic polymer known for its broad-spectrum antimicrobial activity. It primarily exerts its antibacterial effects by interacting with bacterial and fungal cell membranes, leading to disruption of membrane integrity. This compound is valuable in research related to disinfection, water treatment, and agricultural pesticides. -
Fungal Inhibitor
Dihydrochelerythrine is a natural compound derived from Corydalis yanhusuo, primarily functioning as a fungal inhibitor. This compound exhibits notable antifungal activity, making it a valuable reagent for research applications focused on mycology and the study of fungal infections. Its properties may contribute to the development of novel antifungal therapies. -
Fungicide
Flutolanil is a broad-spectrum fungicide that primarily targets mitochondrial Complex II, inhibiting mycelial oxygen consumption and succinate dehydrogenase activity. This compound is effective against various fungal pathogens, making it valuable for managing plant diseases. Additionally, studies indicate that prolonged exposure to Flutolanil may lead to endocrine disruption and reproductive disorders in zebrafish, highlighting its relevance in ecotoxicology research. -
Fungal Inhibitor
Cauloside A, a saponin derived from the roots of Dipsacus asper, serves as a potent fungal inhibitor. It exhibits significant antifungal activity, making it a valuable reagent for research focused on fungal pathogenesis and therapeutic interventions. Its effectiveness in combating various fungal strains positions Cauloside A as a crucial tool in the study of antifungal mechanisms and the development of new antifungal agents. -
Antifungal Agent
Isopropyl ferulate is a naturally occurring compound known for its antifungal properties. It acts by inhibiting fungal growth, making it a valuable candidate for the development of antifungal agents. Additionally, isopropyl ferulate is utilized in pharmaceutical formulations and cosmetic products due to its antioxidant activity, highlighting its versatility in various biological applications.
