Catalog No.
Product Name
Application
Product Information
Citations
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nitroimidazole antibiotic medication
Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. - Polymyxin B Sulfate is a cationic surfactant antibiotic agent. A mixture of polymyxins B1 and B2, increases the permeability of the cell membrane.
- Pyrantel pamoate is a deworming agent in the treatment of hookworms (all species) and roundworms in domesticated animal; acts as a depolarizing neuromuscular blocking agent.
- Pyrazinamide is an antimycobacterial compound that inhibits the growth of the human M. tuberculosis H37Rv strain.
- Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).
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HIV Protease inhibitor
Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease.Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. -
HIV reverse transcriptase inhibitor
Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. - Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.
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nucleoside analogue reverse transcriptase inhibitor
Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. -
HCCR2 antagonist
INCB 3284 dimesylate is a potent, selective hCCR2 antagonist that exhibits potenct antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity. - Lariatins is a novel anti-mycobacterial peptides with a lasso structure produced by Rhodococcus jostii K01-B0171.
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Antiinfective Agent
SMAP-29, a promising antiinfective agent, is a broad spectrum antibacterial and antifungal α-helical cathelicidin-derived peptide. SMAP-29 acts by permeabilizing bacterial membranes and inducing remarkable changes in the surface morphology of susceptible microorganism. -
HIV replication inhibitor
Feglymycin is a HIV replication inhibitor. Feglymycin is also an antibiotic peptide that has antibacterial activity (MIC: 32-64 μg/mL for Staphylococcus aureus). -
Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against, bacteria, fungi, and protozoa at micromolar concentration.
- Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities.
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6-Diazo-5-oxo-L-nor-Leucine is a glutamine antagonist that shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells.
- AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.
- Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α).
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anti-HIV-1 fusion inhibitor
Enfuvirtide (T20; DP178) acetate is an anti-HIV-1 fusion inhibitor peptide. - HSV-gB2 (498-505) is an immunodominant epitope from herpes simplex virus (HSV) glycoprotein B residues 498-505, acts as H-2Kb-restricted and HSV-1/2-cross-reactive cytotoxic T-lymphocyte (CTL) recognition epitope.
- Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM.
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broad-spectrum seed treatment nematicide
Tioxazafen is a disubstituted oxadiazole and a broad-spectrum seed treatment nematicide. Tioxazafen is designed to provide consistent broad-spectrum control of nematodes in corn, soy, and cotton. -
anti-infective agent
Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities. -
human immunodeficiency virus protease inhibitor
Des(benzylpyridyl) Atazanavir is a metabolite of Atazanavir, a human immunodeficiency virus protease inhibitor. -
Aniline receptor activator
Cyantraniliprole(HGW-86) is an insecticide of the ryanoid class; has activity against pests such as Diaphorina citri that have developed resistance to other classes insecticides. -
LolCDE complex inhibitor
LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity. -
Antibiotic
Berberine hemisulfate is an alkaloid with antibiotic properties derived from the traditional Chinese herbal medicine Huanglian. It demonstrates significant antimicrobial activity and possesses anti-inflammatory, antitumor, cardiovascular protective, and neuroprotective effects. This compound is valuable for research applications exploring infections, immune response modulation, and potential therapeutic avenues for various diseases. -
HIV Reverse Transcriptase Inhibitor
β-Rubromycin is a selective inhibitor of HIV-1 reverse transcriptase, exhibiting a Ki of 0.27 μM. Additionally, it demonstrates potent telomerase inhibition with an IC50 of 3 μM. β-Rubromycin effectively inhibits the proliferation of K-562 and HeLa cell lines, showing IC50 values of 19.5 µM and 22.7 µM, respectively, making it a valuable tool for research in HIV and telomerase-related studies. -
Antibacterial Agent
ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor of thyroxine binding globulin (TBG), exhibiting a Ki value of 2.09×10^6 M^-1. This compound is utilized in radioimmunoassays to enhance detection sensitivity by displacing bound triiodothyronine (T3) and facilitating its recognition by antibodies. Additionally, ANS serves as a fluorescent probe, selectively binding to hydrophobic regions of proteins, particularly membrane proteins, allowing for real-time monitoring of protein conformational dynamics through fluorescence changes. Its applications extend to biochemical research and the development of antibacterial materials. -
SIRT Inhibitor
Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity. -
Antihelminthic Agent
Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells. -
Antibiotic
Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases. -
HIV Protease Inhibitor
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives. -
Antibiotic
Erythromycin is a macrolide antibiotic that targets bacterial 50S ribosomal subunits, effectively inhibiting RNA-dependent protein synthesis by obstructing transpeptidation and translocation reactions. This compound demonstrates a broad spectrum of antimicrobial activity against various bacteria, making it valuable in microbiological research. Additionally, erythromycin has been shown to possess antitumor and neuroprotective properties, contributing to its usefulness in diverse areas of biomedical research. -
Apoptosis Inducer
Sanguinarine chloride is a benzophenanthridine alkaloid that functions as an apoptosis inducer primarily through the generation of reactive oxygen species (ROS). This compound is known to activate key signaling pathways, specifically JNK and NF-κB, facilitating programmed cell death. Sanguinarine chloride is widely utilized in cancer research and studies investigating apoptotic mechanisms. -
Antibiotic
Tetracycline is a broad-spectrum antibiotic that targets bacterial protein synthesis by binding to the 30S ribosomal subunit, inhibiting translation. It demonstrates activity against a diverse array of microorganisms, including gram-positive and gram-negative bacteria, as well as chlamydiae, mycoplasmas, and rickettsiae. This compound is widely utilized in research related to bacterial infections and antibiotic resistance mechanisms. -
Bacterial Inhibitor
Cefamandole sodium is a second-generation broad-spectrum cephalosporin antibiotic that primarily targets bacterial cell wall synthesis. It exhibits significant antibacterial activity against a variety of gram-positive and gram-negative bacteria, making it valuable for research into antimicrobial resistance and the mechanisms of bacterial infections. This compound is commonly utilized in studies assessing the efficacy of antibiotic treatments and in exploring bacterial susceptibility profiles. -
Fluorescent Dye
Acridine Orange base is a cell-permeable fluorescent dye primarily utilized for staining nucleic acids in various organisms, including bacteria, parasites, and viruses. This dye exhibits distinct fluorescence characteristics; it emits green light when bound to double-stranded DNA (Ex=488 nm, Em=520-524 nm) and red light when associated with single-stranded DNA or RNA (Ex=457 nm, Em=630-644 nm). Acridine Orange base is particularly valuable in fluorescence microscopy for distinguishing human cells under acidic conditions (pH=3.5) and is widely employed in cell cycle assays. -
Photobase Reagent
Malachite Green Carbinol Base acts as a photobase reagent, capable of releasing hydroxide ions (OH-) upon ultraviolet light irradiation. This reaction facilitates a progressive shift in pH levels, allowing for precise pH regulation in experimental settings. When exposed to high-intensity UV light (500 W, 50 W/cm), the solution transitions rapidly from colorless to deep green, which can be utilized for applications in photochemistry and environmental monitoring. -
Antiviral Agent
Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.
