Catalog No.
Product Name
Application
Product Information
Citations
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HIV-1 Inhibitor
HIV-1 inhibitor-25 (compound R-12a) is a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an IC50 value of 0.1061 μM. This compound demonstrates significant antiretroviral activity against wild-type HIV-1, with an EC50 of 13.6 nM, while maintaining low cytotoxicity (CC50 of 33.13 μM) in MT-4 cells. Additionally, HIV-1 inhibitor-25 shows inhibitory effects on various HIV-1 mutant strains, presenting EC50 values ranging from 0.1961 to 5.8136 μM. This reagent is valuable for research focused on HIV/AIDS therapies. -
Reverse Transcriptase Inhibitor
(+)-Dihydrocalanolide A is a non-nucleoside inhibitor of Reverse Transcriptase, exhibiting oral bioactivity. This compound demonstrates significant inhibitory effects on HIV replication and is valuable in research investigating HIV infection mechanisms and potential therapeutic strategies. Its pharmacological profile supports its use in studies aimed at understanding antiviral activities and developing new HIV treatments. -
HIV-1 Protease Inhibitor
HIV-1 protease-IN-6 is a potent inhibitor of HIV-1 protease, demonstrating an impressive IC50 of 21 pM and a Ki of 4.7 pM. This compound displays significant antiviral activity against darunavir-resistant variants, surpassing that of the wild type virus. Its high potency and efficacy make it a valuable tool for researching HIV-1 replication and resistance mechanisms. -
HIV-1 RT Inhibitor
Calcium mesoxalate is an inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 value of 2.2 μM. This compound demonstrates significant antiviral activity, making it a valuable tool for researchers studying HIV-1 replication mechanisms and potential therapeutic interventions. Its application in the investigation of HIV-1 RT’s role in viral propagation can aid in the development of novel antiviral strategies. -
HIV-1/microtubule Inhibitor
Wikstrol B is a biflavonoid that acts as an inhibitor of microtubule polymerization and HIV-1 replication. It demonstrates an IC50 value of 184 μM for microtubule inhibition and an EC50 of 3.02 μM against HIV-1, affecting early replication processes. Additionally, Wikstrol B displays antifungal activity by inducing morphological changes in Pyricularia oryzae hyphae and exhibits anti-mitotic properties. This compound is valuable for research into antifungal, antitumor, and anti-HIV therapeutic applications. Naturally extracted from the roots of Wikstroemia indica, it offers a unique avenue for investigations in these domains. -
HIV Inhibitor
KP-1212 is a nucleoside analog that functions as an HIV inhibitor through the mechanism of mutagenizing the viral genome. This unique action compromises viral replication, effectively inhibiting HIV growth. KP-1212 is primarily utilized in research focusing on antiviral drug development and the mechanisms of HIV pathogenesis. -
HIV Inhibitor
GPS491 is an HIV inhibitor that targets the regulation of viral RNA expression. With an EC50 value of 0.47 μM, GPS491 effectively suppresses the expression of the HIV-1 structural protein Gag and modifies the accumulation of HIV-1 RNA. This compound decreases the levels of RNA encoding structural proteins while enhancing the abundance of regulatory protein RNAs, making it a valuable tool for studying HIV biology and potential therapeutic interventions. -
HIV-1 Inhibitor
HIV-1 inhibitor-32 is a potent inhibitor targeting HIV-1, demonstrating an IC50 value of 34 nM against wild-type HIV-1. This compound is valuable for investigating pathways of HIV replication and can assist in the development of therapeutic strategies for AIDS research. Its efficacy makes it a crucial tool for studies aimed at understanding HIV-1 pathogenesis and treatment options. -
HIV-1 Inhibitor
HIV-1 inhibitor-55 is a potent inhibitor targeting wild-type HIV-1, exhibiting an EC50 value of 8.6 nM. This compound also displays significant inhibitory activity against both single and double HIV-1 mutants, making it a valuable tool for studying viral resistance mechanisms. HIV-1 inhibitor-55 is applicable in research focused on HIV-1 infection and potential therapeutic interventions. -
HIV-1 Inhibitor
PF-46396 is a potent inhibitor of HIV-1, exhibiting an effective concentration (EC50) of 0.206 µM. It demonstrates significant antiviral activity by inhibiting the processing of the capsid (CA) and spacer peptide 1 (SP1) from the Gag precursor proteins. This blockade effectively disrupts the maturation of the viral core particle, making PF-46396 a valuable tool for research in HIV-1 mechanisms and potential therapeutic interventions. -
HIV-1 Inhibitor
HIV-1 Inhibitor-52 is a potent inhibitor targeting the HIV-1 virus, demonstrating broad-spectrum antiviral activity. With effective concentrations (EC50) ranging from 1.6 nM to 6.4 nM against a variety of wild-type and mutant strains, including HIV-1 V370A and HIV-1 T332S/V362I/prR41G, this compound is valuable for research into HIV-1 pathways. It serves as a critical tool for studies focused on the mechanisms of HIV resistance and potential therapeutic strategies. -
HIV-1 Capsid Inhibitor
HIV-1 Inhibitor-18 is a potent inhibitor specifically targeting the HIV-1 capsid with an EC50 value of 5.14 μM against HIV-1 NL4-3. This compound displays cytotoxicity, showing an MT-4 cell CC50 greater than 9.51 μM. It serves as a valuable tool for researching HIV-1 replication mechanisms and potential therapeutic interventions against HIV-1 infection. -
HIV-1 Inhibitor
HIV-1 inhibitor-14 is a potent non-nucleoside reverse transcriptase (RT) inhibitor targeting HIV-1. It demonstrates strong inhibitory activity with an EC50 of 0.14 μM against HIV-1 RT and is effective against both wild-type and resistant strains, with EC50 values ranging from 5.79 to 28.3 nM. This compound is valuable for research applications focused on understanding HIV-1 resistance mechanisms and developing antiviral therapies. -
HIV-1 gp120 Inhibitor
gp120-IN-2 is a potent inhibitor of the HIV-1 gp120 protein, exhibiting an IC50 of 7.5 µM while demonstrating a CC50 of 112.93 µM. This compound effectively inhibits HIV-1 replication, showcasing anti-HIV-1 activity. Additionally, gp120-IN-2 exhibits dose-dependent cytotoxicity in SUP-T1 cells, making it a valuable tool for studying HIV-1 and potential therapeutic interventions. -
HIV-1 Inhibitor
U-89360E is a selective inhibitor of HIV-1 protease, demonstrating potent activity against the wildtype strain as well as the V82D and V82N mutants, with inhibitory constants (Ki) of 20 nM, 560 nM, and 2100 nM, respectively. Its effectiveness against multiple viral variants makes it a valuable tool for antiviral research and the development of therapeutic strategies targeting HIV-1. U-89360E is particularly relevant for studies focusing on resistance patterns and protease inhibition in the context of HIV treatment. -
HIV-1 Inhibitor
HIV-1 Inhibitor-23 is a potent non-nucleoside reverse transcriptase inhibitor targeting HIV-1. It exhibits effective inhibition with EC50 values of 24.9 nM for wild-type HIV-1 and 10.4 nM for the HIV-1 K103N mutant. Additionally, HIV-1 Inhibitor-23 demonstrates low cytotoxicity with a CC50 exceeding 221 μM and displays favorable stability in vitro under microsomal conditions, making it a valuable tool for HIV research and drug development. -
HIV-1 Protease Inhibitor
L 694746 is a potent inhibitor of HIV-1 protease, demonstrating an IC50 value of 1 nM and a Ki of 0.34 nM. This compound exhibits strong antiviral activity, making it a valuable reagent in the study of HIV replication and resistance mechanisms. Its effectiveness in inhibiting protease activity underscores its potential applications in HIV research and therapeutic development. -
HIV-1 Inhibitor
DMJ-I-228 is a CD4-mimetic compound that targets HIV-1 by binding to the gp120 protein within the conserved Phe 43 cavity, which is adjacent to the CD4-binding site. This interaction effectively obstructs the binding of CD4, leading to the inhibition of HIV-1 infection. DMJ-I-228 is utilized in research focused on HIV-1 entry mechanisms and the development of antiviral therapies. -
HIV
APA-APA-MPO dihydrochloride is an inhibitor of the PCAF bromodomain and its interaction with Tat-AcK50, demonstrating a reduction in cytotoxicity. This compound effectively hinders the binding of PCAF to Tat-AcK50, highlighting its potential as a therapeutic agent in HIV/AIDS research. APA-APA-MPO dihydrochloride can be utilized in studies aimed at inhibiting HIV replication. -
HIV Protease Inhibitor
DMP-851 is a potent cyclic urea inhibitor of HIV protease, exhibiting a Ki of 0.021 nM. It demonstrates significant antiviral activity against both laboratory strains of HIV-1 and HIV-2, as well as primary clinical isolates that are resistant to Zidovudine. This compound serves as an important tool for research into HIV treatment and resistance mechanisms. -
HIV
5M038 is a potent inhibitor of HIV envelope-mediated fusion that targets the gp41 protein to prevent membrane fusion. By inhibiting the formation of the gp41 post-fusion conformation, 5M038 effectively disrupts viral infectivity and cell-cell fusion. Its broad-spectrum activity includes inhibition against multiple HIV-1 subtypes, including M and T strains, due to its binding to a highly conserved hydrophobic pocket within the gp41 trimer. This makes 5M038 a valuable tool for research in HIV fusion mechanisms and antiviral drug development. -
HIV
ZINC36617540 is a novel inhibitor targeting the Nef protein, demonstrating potent anti-HIV activity. It exhibits a strong binding affinity to the Nef protein and shares a comparable binding mode with the prototype molecule B9, as shown through molecular docking studies. The mechanism of action is primarily attributed to its hydrophobic and electrostatic interactions with the Nef protein, making it a valuable tool for HIV research and the development of antiviral therapeutics. -
HIV Inhibitor
DAPD-NHc-pr is an HIV inhibitor that demonstrates potent antiviral activity with EC50 and EC90 values of 0.85 μM and 13 μM, respectively. This compound exhibits minimal toxicity to normal cells, including peripheral blood mononuclear cells (PBM), CEM, and VERO cell lines. DAPD-NHc-pr is valuable for studying HIV replication and exploring potential therapeutic strategies against HIV infection. -
HIV Protease Inhibitor
BILA 1906 BS is a potent HIV protease inhibitor that disrupts HIV-1 replication by inhibiting the protease-mediated cleavage of Gag and Gag-Pol polyprotein precursors during virion maturation. This compound effectively blocks the maturation of p24 proteins in wild-type HIV-1, thereby impairing polyprotein processing and viral maturation. BILA 1906 BS is valuable for research focused on human immunodeficiency virus type 1 (HIV-1) infection and its associated cellular mechanisms. -
HIV Inhibitor
HIV-1 inhibitor-72 is a potent inhibitor targeting the HIV-1 virus. Its primary mechanism involves binding to essential viral proteins, effectively inhibiting viral replication. This compound is valuable for research in virology and HIV-related studies, particularly in the development of therapeutics aimed at eradicating HIV-1 infection. -
Anti-HIV-1 Nucleoside Analog
QYL-685 is an anti-HIV-1 nucleoside analog featuring a Z-methenylcyclopropane structure with 2,6-diaminopurine, demonstrating significant antiviral activity against HIV-1. This compound is effective against HIV-1 strains resistant to Zidovudine and Didanosine in vitro. QYL-685 serves as a valuable tool for researching HIV-1 infection and evaluating antiviral mechanisms. -
HIV-1 Inhibitor
HIV-1 inhibitor-27 is a potent inhibitor targeting HIV-1, exhibiting IC50 values of 16 μM, 0.5 μM, and 0.39 μM against HIV-1 YU2, NL4-3, and 89.6 strains, respectively. This compound demonstrates low cytotoxicity, with a CC50 of 128 μM in TZM-bl cells. HIV-1 inhibitor-27 is suitable for research applications focused on understanding and combating AIDS-related mechanisms. -
HIV-1 Inhibitor
(+)-PM 92131 is a non-nucleoside inhibitor of HIV-1 that specifically targets viral replication. It demonstrates significant anti-HIV-1 activity with EC50 values of 0.8 μM and 0.6 μM against the HIV-1 RF strain, as evidenced by XTT cytoprotection and syncytium-forming assays, respectively. This compound is suitable for research applications focused on HIV infections and the mechanisms of viral inhibition. -
HIV-1 Reverse Transcriptase Inhibitor
L 697661 is an orally active inhibitor of HIV-1 reverse transcriptase, targeting the essential enzyme required for the replication of the virus. This compound demonstrates potent antiviral activity against HIV-1, making it a valuable tool for research in HIV treatment and therapies. Its ability to interrupt viral replication pathways provides critical insights into antiviral drug development and therapeutic efficacy studies. -
HIV-1 Inhibitor
HIV-1 Inhibitor-26 is a potent inhibitor of HIV-1 reverse transcriptase (RT), demonstrating an IC50 value of 1.4 μM. This compound exhibits low cytotoxicity, with a CC50 of 1486 μM in peripheral blood mononuclear cells (PBMCs). HIV-1 Inhibitor-26 is suitable for research applications focused on AIDS and the mechanisms of HIV replication. -
HIV Inhibitor
Nevirapine quinone methide is an active metabolite of Nevirapine, functioning as a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1. This compound is utilized in research to explore its antiviral properties and the mechanisms behind its associated toxicities, including severe skin and liver injuries resulting from its metabolic activation. Additionally, Nevirapine quinone methide has been identified as an inhibitor of CYP3A4, which may further elucidate its hepatic toxicity in studies focused on drug metabolism and safety. -
HIV Inhibitor
BMS-663749 lysine is a prodrug of an HIV-1 attachment inhibitor that enhances the bioavailability of the parent compound upon oral administration. This compound exhibits potent antiviral activity against HIV-1 by blocking the virus's ability to bind to host cells. Research applications include studying HIV-1 entry mechanisms and exploring therapeutic strategies for HIV infection. -
HIV-1 RT Inhibitor, HIV-1 Inhibitor
S-2720 is a potent inhibitor of HIV-1 reverse transcriptase (HIV-1 RT) and effectively suppresses HIV-1 replication. It binds to overlapping sites on the enzyme, likely targeting a pocket within the p66 subunit, which is critical for reverse transcription. As a quinoxaline derivative, S-2720 demonstrates significant potential for advancing research in HIV-1 infection and developing therapeutic strategies against this virus. -
HIV Inhibitor
HI-253 is a non-nucleoside inhibitor of HIV-1 reverse transcriptase, exhibiting significant antiviral activity against both resistant and sensitive strains of HIV-1. This compound serves as a valuable tool for research focused on HIV treatment and the mechanisms of viral resistance, making it essential for studies aimed at developing new therapeutic strategies against HIV. -
Anti-HIV Agent
Isoapetalic acid is a potent anti-HIV agent that targets viral replication mechanisms. This compound exhibits significant activity against HIV, making it a valuable tool for research in virology and therapeutic development. Its effectiveness in modulating viral processes positions it as a candidate for further exploration in the context of HIV treatment strategies. -
HIV Inhibitor
[(Cys(Bzl)84,Glu(OBzl)85)]CD4 (81-92) functions as a selective inhibitor of HIV-1 by obstructing the interaction between the virus and CD4 molecules. This compound demonstrates significant antiviral activity by effectively inhibiting viral infection and cell fusion. Research applications include studies focused on HIV treatment mechanisms and exploration of CD4 receptor interactions, with complete inhibition of fusion formation observed at a concentration of 25 μM. -
HIV Inhibitor
HIV-1 protease-IN-1 is a highly potent inhibitor of the HIV-1 protease, exhibiting an IC50 of 90 pM. This compound demonstrates significant antiviral activity, with EC50 values of 89 nM against the B-HIV strain and 13.59 nM against the C-HIV strain ZM246, as well as an impressive EC50 of 8.23 nM against the C-HIV strain Indie. HIV-1 protease-IN-1 serves as a valuable tool for research and development in HIV treatment strategies and antiviral drug discovery. -
HIV-1 gp120 Inhibitor
gp120-IN-1 is a potent inhibitor targeting the HIV-1 gp120 protein. It demonstrates significant anti-HIV-1 activity with an IC50 value of 2.2 µM, while exhibiting a CC50 of 100.90 µM in SUP-T1 cells, indicating dose-dependent cytotoxicity. This compound effectively inhibits gp120-mediated viral entry into host cells, making it a valuable tool for research in HIV therapeutics and virology studies. -
HIV Inhibitor
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium is a potent HIV inhibitor that demonstrates significantly prolonged half-life values compared to tenofovir in human liver microsomes. This compound exhibits robust anti-HIV activity in vitro and shows enhanced pharmacokinetic properties in vivo. Additionally, it serves as a click chemistry reagent featuring an alkyne group, which allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various research applications in medicinal chemistry and drug development. -
Anti-HIV-1 Agent
VIR-165 is an anti-HIV-1 agent that functions by binding to the fusion peptide of the gp41 subunit, preventing its insertion into the target membrane. This action effectively inhibits a diverse range of human immunodeficiency virus type 1 (HIV-1) strains. VIR-165 is valuable for research applications focused on viral entry mechanisms and the development of novel therapeutic strategies against HIV-1. -
HIV-1 Protease Inhibitor
CGP 53437 is a potent HIV-1 protease inhibitor, exhibiting a Ki value of 0.2 nM. This compound effectively inhibits HIV replication, making it a valuable tool for research focused on HIV pathogenesis and antiviral therapy development. Its oral bioactivity supports studies in pharmacokinetics and therapeutic interventions against HIV. -
HIV-1 Polypeptide
Cys-TAT(47-57) is a cell-penetrating peptide derived from the HIV-1 transactivating protein, specifically comprising the sequence Cys-[HIV-Tat (47-57)]. This arginine-rich peptide facilitates the delivery of therapeutic agents across cellular membranes. It is primarily utilized in research focused on HIV biology and the development of peptide-based drug delivery systems. -
Reverse Transcriptase Inhibitor
BILR 355 is a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) that specifically targets HIV-1 reverse transcriptase. This compound demonstrates potent inhibition of viral replication, making it a valuable tool for research on HIV infections and the development of antiviral therapies. BILR 355's selectivity and effectiveness in disrupting reverse transcription make it an important reagent for studying HIV biology and drug resistance. -
HIV Inhibitor
(-)-6-Aminocarbovir is an antiviral compound that acts as a potent inhibitor of HIV replication. It demonstrates significant biological activity against the virus, making it a valuable tool in HIV research. This reagent is applicable for studies focusing on viral infections and the development of antiviral therapies. -
HIV-1 Reverse Transcriptase Inhibitor
U 88204 is a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an IC50 value of 0.25 μM. This compound effectively blocks the replication of HIV-1 in infected cells, making it a valuable tool for research focused on HIV infection and acquired immunodeficiency syndrome (AIDS). Its specificity and efficacy facilitate studies aimed at understanding the mechanisms of viral replication and the development of antiviral therapies. -
HIV Inhibitor
VCH-286 is a selective CCR5 inhibitor that demonstrates significant in vitro activity against HIV-1. This compound effectively blocks the CCR5 co-receptor, preventing viral entry into host cells. VCH-286 is particularly useful for research applications focused on understanding HIV-1 pathogenesis and developing therapeutic strategies targeting CCR5-mediated viral infections. -
CCR5 Inhibitor
CMPD167 is a selective CCR5 inhibitor that exerts its antiviral effects by blocking the CCR5 receptor, which is critical for the entry of certain viruses into host cells. This compound demonstrates potent antiviral activity in vitro, making it a valuable tool for research on viral infections, particularly in studies related to HIV. CMPD167 can facilitate investigations into CCR5-related pathways and the development of therapeutic strategies targeting viral entry mechanisms. -
HIV-1 Latency Reversing Agent
HIV-1 protease-IN-10 is a potent HIV-1 latency reversing agent with an IC50 of 0.22 μM. This compound selectively binds to the PKCδ C1b domain, exhibiting an IC50 of 0.69 μM. Additionally, HIV-1 protease-IN-10 demonstrates stability against esterase-mediated hydrolysis, making it suitable for research applications in HIV latency and reactivation studies. -
Nucleoside Reverse Transcriptase Inhibitor
Amdoxovir is a nucleoside reverse transcriptase inhibitor that acts as a prodrug of dioxolane guanosine. It demonstrates efficacy against both wild-type and nucleoside reverse transcriptase inhibitor-resistant HIV strains. Amdoxovir is utilized in research related to HIV/AIDS, providing insight into antiviral mechanisms and potential therapeutic strategies.
