Kuwanon L is an inhibitor of HIV-1 integrase that effectively disrupts the interaction between HIV-1 integrase and LEDGF/p75, demonstrating IC50 values of 42 µM for LEDGF-dependent and 34 µM for LEDGF-independent integrase activity. With an IC50 of 22 µM for the integrase-LEDGF/p75 interaction, Kuwanon L also inhibits HIV-1 replication in immune cells. This compound is valuable for research focused on HIV-1 infection and the mechanisms underlying viral integration.
Kuwanon L is an inhibitor of HIV-1 integrase that effectively disrupts the interaction between HIV-1 integrase and LEDGF/p75, demonstrating IC50 values of 42 µM for LEDGF-dependent and 34 µM for LEDGF-independent integrase activity. With an IC50 of 22 µM for the integrase-LEDGF/p75 interaction, Kuwanon L also inhibits HIV-1 replication in immune cells. This compound is valuable for research focused on HIV-1 infection and the mechanisms underlying viral integration.
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