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PKHB1

Catalog No.: A39225
Peptide Mimic
PKHB1 is a thrombospondin-1 peptide mimic that exerts antitumor effects primarily through mitochondrial dysfunction. It promotes the production of reactive oxygen species (ROS), triggers intracellular calcium accumulation, and activates calcium-dependent apoptotic pathways in breast cancer cells. Additionally, PKHB1 facilitates immune system activation by inducing immunogenic cell death, making it a valuable tool for research into cancer therapeutics and immunology.
PKHB1 1505523-99-8 Peptide Mimic
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPKHB1 is a thrombospondin-1 peptide mimic that exerts antitumor effects primarily through mitochondrial dysfunction. It promotes the production of reactive oxygen species (ROS), triggers intracellular calcium accumulation, and activates calcium-dependent apoptotic pathways in breast cancer cells. Additionally, PKHB1 facilitates immune system activation by inducing immunogenic cell death, making it a valuable tool for research into cancer therapeutics and immunology.
Product Information
Catalog NumA39225
FormulaC68H105N17O12S
Molecular Weight1384.73
CAS Number1505523-99-8
Sequence{d-Lys}-Arg-Phe-Tyr-Val-Val-Met-Trp-Lys-{d-Lys}
Sequence shortening{d-Lys}-RFYVVMWK-{d-Lys}
SMILESC([C@@H](C(N[C@H](C(N[C@H](CCCCN)C(O)=O)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](CCCCN)N)=O)CCCNC(=N)N)=O)=O)=O)C(C)C)=O)[C@H](C)C)=O)CCSC)=O)C=3C=4C(NC3)=CC=CC4
SynonymstxCD47
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