Brevicidine

Brevicidine is an antimicrobial peptide that demonstrates selective bactericidal activity against Gram-negative pathogens. It functions by binding to lipopolysaccharide (LPS) on the bacterial cell membrane, leading to pore formation and subsequent disruption of bacterial morphology. This results in the dissipation of the proton motive force, outer membrane damage, inhibition of ATP biosynthesis, and accumulation of reactive oxygen species within bacterial cells. Additionally, Brevicidine acts as a sensitizer, exhibiting synergistic effects when combined with various conventional antibiotics, making it valuable for research in antimicrobial resistance and antibiotic enhancement studies.