KWWCRW is a Holliday linker inhibitory peptide that targets homologous recombination repair (HDR) in DNA repair mechanisms. By binding to the reactive Holliday linker intermediate, KWWCRW prevents its degradation, thereby inhibiting HDR and site-specific recombination by bacteriophage in vitro. This peptide is valuable in cancer research, particularly in studying DNA repair pathways and potential therapeutic interventions.
KWWCRW is a Holliday linker inhibitory peptide that targets homologous recombination repair (HDR) in DNA repair mechanisms. By binding to the reactive Holliday linker intermediate, KWWCRW prevents its degradation, thereby inhibiting HDR and site-specific recombination by bacteriophage in vitro. This peptide is valuable in cancer research, particularly in studying DNA repair pathways and potential therapeutic interventions.
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