CNI103 is a potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. By selectively inhibiting the interaction between calcineurin and NFATc3, with a binding affinity of KD=16 nM, CNI103 effectively prevents NFATc3 activation both in vitro and in vivo. This reagent is valuable for investigating mechanisms involved in acute respiratory distress syndrome (ARDS) and other inflammatory diseases.
CNI103 is a potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. By selectively inhibiting the interaction between calcineurin and NFATc3, with a binding affinity of KD=16 nM, CNI103 effectively prevents NFATc3 activation both in vitro and in vivo. This reagent is valuable for investigating mechanisms involved in acute respiratory distress syndrome (ARDS) and other inflammatory diseases.
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