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TFLLRNPNDK-NH2

Catalog No.: A77941
Bioactive Peptide
TFLLRNPNDK-NH2 is a bioactive peptide that acts as a potent agonist of the protease-activated receptor 1 (PAR-1). By mimicking the tethered ligand generated by thrombin proteolytic cleavage, this peptide reversibly binds to PAR-1, modulating various cellular responses. Key biological activities include the enhancement of liquid and protein permeability, making it valuable for research applications in cardiovascular and inflammatory studies.
TFLLRNPNDK-NH2 145229-90-9 Bioactive Peptide
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTFLLRNPNDK-NH2 is a bioactive peptide that acts as a potent agonist of the protease-activated receptor 1 (PAR-1). By mimicking the tethered ligand generated by thrombin proteolytic cleavage, this peptide reversibly binds to PAR-1, modulating various cellular responses. Key biological activities include the enhancement of liquid and protein permeability, making it valuable for research applications in cardiovascular and inflammatory studies.
Product Information
Catalog NumA77941
FormulaC54H89N17O15
Molecular Weight1216.39
CAS Number145229-90-9
SequenceThr-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-NH2
Sequence shorteningTFLLRNPNDK-NH2
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H]([C@@H](C)O)N)=O)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)=O)CC(N)=O)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CC(O)=O)=O)CC(N)=O)=O)CCC2
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