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CaMKI(299-320)

Catalog No.: A78516
Calcium/calmodulin-dependent Protein Kinase I Peptide
CaMKI (299-320) is a peptide derived from the calcium/calmodulin-dependent protein kinase I, encompassing residues 299 to 320. This peptide exhibits a high-affinity interaction with Ca2+-calmodulin (Kd ≤ 1 nM) and is capable of phosphorylating target substrate proteins, thus modulating their biological activity. Due to its functional domains, including the calmodulin-binding and self-inhibition domains, CaMKI (299-320) is a valuable tool for investigating cellular physiological processes such as proliferation, differentiation, and apoptosis.
CaMKI(299-320) 205598-38-5 Calcium/calmodulin-dependent Protein Kinase I Peptide
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCaMKI (299-320) is a peptide derived from the calcium/calmodulin-dependent protein kinase I, encompassing residues 299 to 320. This peptide exhibits a high-affinity interaction with Ca2+-calmodulin (Kd ≤ 1 nM) and is capable of phosphorylating target substrate proteins, thus modulating their biological activity. Due to its functional domains, including the calmodulin-binding and self-inhibition domains, CaMKI (299-320) is a valuable tool for investigating cellular physiological processes such as proliferation, differentiation, and apoptosis.
Product Information
Catalog NumA78516
FormulaC116H192N38O28S
Molecular Weight2599.07
CAS Number205598-38-5
SequenceAla-Lys-Ser-Lys-Trp-Lys-Gln-Ala-Phe-Asn-Ala-Thr-Ala-Val-Val-Arg-His-Met-Arg-Lys-Leu-Gln
Sequence shorteningAKSKWKQAFNATAVVRHMRKLQ
SMILESC([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CC(C)C)=O)CCCCN)=O)CCCNC(=N)N)=O)CCSC)=O)=O)CCCNC(=N)N)=O)C(C)C)=O)C(C)C)=O)C)=O)[C@@H](C)O)=O)C)=O)CC(N)=O)=O)=O)C)=O)CCC(N)=O)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](C)N)=O)=O)CO)=O)CCCCN)=O)C=3C=4C(NC3)=CC=CC4
SynonymsCalmodulin-Dependent Protein Kinase I (299-320) Binding Domain
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