Abz-HPGGPQ-EDDnp is a bioactive peptide designed as a selective substrate for cathepsin K, a lysosomal cysteine protease crucial for bone remodeling and resorption. This fluorescence resonance energy transfer (FRET) peptide is specifically cleaved at the Gly-Gly bond by cathepsin K, enabling precise monitoring of its activity in physiological fluids and cell lysates. The peptide demonstrates resistance to hydrolysis by other cathepsins, thereby facilitating targeted research into autoimmune diseases and osteoporosis. Abz-HPGGPQ-EDDnp is characterized by excitation/emission wavelengths of 340 nm/420 nm, making it a valuable tool for studying protease activity in cellular contexts.
Abz-HPGGPQ-EDDnp is a bioactive peptide designed as a selective substrate for cathepsin K, a lysosomal cysteine protease crucial for bone remodeling and resorption. This fluorescence resonance energy transfer (FRET) peptide is specifically cleaved at the Gly-Gly bond by cathepsin K, enabling precise monitoring of its activity in physiological fluids and cell lysates. The peptide demonstrates resistance to hydrolysis by other cathepsins, thereby facilitating targeted research into autoimmune diseases and osteoporosis. Abz-HPGGPQ-EDDnp is characterized by excitation/emission wavelengths of 340 nm/420 nm, making it a valuable tool for studying protease activity in cellular contexts.
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