BTA-EG6 is a brain-penetrant binder that selectively targets aggregated amyloid-β (Aβ) peptides, exhibiting a dissociation constant (Kd) of 290 nM for Aβ1-42. This compound forms protective protein-resistive coatings that inhibit interactions between Aβ and catalase, thereby reducing neurotoxic effects. In functional assays, BTA-EG6 demonstrates protective effects against Aβ-induced cytotoxicity and oxidative stress, effectively decreasing hydrogen peroxide (H2O2) levels in neuroblastoma cells. This reagent is valuable for research focusing on Alzheimer’s disease (AD) and associated mechanisms of neurotoxicity.
BTA-EG6 is a brain-penetrant binder that selectively targets aggregated amyloid-β (Aβ) peptides, exhibiting a dissociation constant (Kd) of 290 nM for Aβ1-42. This compound forms protective protein-resistive coatings that inhibit interactions between Aβ and catalase, thereby reducing neurotoxic effects. In functional assays, BTA-EG6 demonstrates protective effects against Aβ-induced cytotoxicity and oxidative stress, effectively decreasing hydrogen peroxide (H2O2) levels in neuroblastoma cells. This reagent is valuable for research focusing on Alzheimer’s disease (AD) and associated mechanisms of neurotoxicity.
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