Ala286-Calmodulin-Dependent Protein Kinase II (281-302)

Catalog No.: A78520
CaMKII Active Peptide
[Ala286]-Calmodulin-Dependent Protein Kinase II (281-302) is a modified peptide fragment of calcium/calmodulin-dependent protein kinase II (CaMKII), featuring an alanine substitution at position 286. This alteration enhances its functional characteristics, making it a valuable tool for the development of potent CaMKII inhibitors. It is primarily used in research applications focused on understanding CaMKII's regulatory roles in cellular processes and signaling pathways.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description[Ala286]-Calmodulin-Dependent Protein Kinase II (281-302) is a modified peptide fragment of calcium/calmodulin-dependent protein kinase II (CaMKII), featuring an alanine substitution at position 286. This alteration enhances its functional characteristics, making it a valuable tool for the development of potent CaMKII inhibitors. It is primarily used in research applications focused on understanding CaMKII's regulatory roles in cellular processes and signaling pathways.
Product Information
Catalog NumA78520
Molecular Weight2600.08
CAS Number141055-85-8
SequenceMet-His-Arg-Gln-Glu-Ala-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala
Sequence shorteningMHRQEAVDCLKKFNARRKLKGA
SMILES[C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@H](CCSC)N)=O)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCC(O)=O)=O)C)=O)C(C)C)=O)CC(O)=O)=O)CS)=O)CC(C)C)=O)CCCCN)=O)CCCCN)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)C)=O)=O)CCCCN)=O)CC(C)C)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)C)=O)CC(N)=O)=O
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