Propargyl-PEG5-amine is a non-cleavable linker utilized in antibody-drug conjugates (ADCs) and PROTAC synthesis. This PEG-based compound features an alkyne functional group, enabling efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Propargyl-PEG5-amine is valuable for researchers developing innovative therapeutic strategies involving targeted protein degradation and selective delivery of cytotoxic agents.
Propargyl-PEG5-amine is a non-cleavable linker utilized in antibody-drug conjugates (ADCs) and PROTAC synthesis. This PEG-based compound features an alkyne functional group, enabling efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Propargyl-PEG5-amine is valuable for researchers developing innovative therapeutic strategies involving targeted protein degradation and selective delivery of cytotoxic agents.
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