Aminooxy-PEG2-azide is a PEG-based PROTAC linker that facilitates the synthesis of protein degraders. This non-cleavable 2-unit PEG linker is also utilized in the preparation of antibody-drug conjugates (ADCs). As a versatile click chemistry reagent, it features an azide group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its applications are essential in advancing targeted protein degradation and ADC development.
Aminooxy-PEG2-azide is a PEG-based PROTAC linker that facilitates the synthesis of protein degraders. This non-cleavable 2-unit PEG linker is also utilized in the preparation of antibody-drug conjugates (ADCs). As a versatile click chemistry reagent, it features an azide group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its applications are essential in advancing targeted protein degradation and ADC development.
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