Azido-PEG5-acid is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This non-cleavable linker facilitates the development of conjugates and antibody-drug conjugates (ADCs) through its azide functionality. Azido-PEG5-acid participates in click chemistry, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates, and can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its versatility makes it valuable for various applications in chemical biology and drug discovery.
Azido-PEG5-acid is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This non-cleavable linker facilitates the development of conjugates and antibody-drug conjugates (ADCs) through its azide functionality. Azido-PEG5-acid participates in click chemistry, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates, and can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its versatility makes it valuable for various applications in chemical biology and drug discovery.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
