Azide-PEG3-Tos is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This non-cleavable linker consists of a three-unit polyethylene glycol (PEG) structure, making it suitable for the development of antibody-drug conjugates (ADCs). Azide-PEG3-Tos acts as a click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its versatile reactivity and stability make it a valuable tool in chemical biology research and drug development.
Azide-PEG3-Tos is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This non-cleavable linker consists of a three-unit polyethylene glycol (PEG) structure, making it suitable for the development of antibody-drug conjugates (ADCs). Azide-PEG3-Tos acts as a click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its versatile reactivity and stability make it a valuable tool in chemical biology research and drug development.
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