Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
4-(2-Bromoethyl)phenol is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target binding moieties to E3 ligase ligands, enabling targeted protein degradation. It is instrumental in the development of innovative therapeutic strategies through modulation of cellular pathways in various biological research applications. -
PROTAC Linker
4-Bromo-1-trimethylsilyl-1-butyne serves as a versatile linker for the development of PROTAC (proteolysis-targeting chimera) molecules. Its unique structural features facilitate the conjugation of target ligands, thereby enabling the selective degradation of proteins through the ubiquitin-proteasome system. This compound is critical for advancing research in targeted protein degradation and enhancing therapeutic strategies in cancer and other diseases. -
PROTAC Linker
N-Fmoc-8-aminooctanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain that includes a terminal Fmoc-protected amine and a carboxylic acid group. The Fmoc group can be removed under basic conditions to yield a free amine amenable for further modifications. Additionally, the carboxylic acid can react with primary amines in the presence of coupling agents, such as EDC or HATU, to establish stable amide bonds, thus enhancing the structural diversity of PROTAC molecules for targeted protein degradation studies. -
PROTAC Linkers
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the conjugation of target proteins with E3 ligases, thereby promoting targeted degradation pathways. Its application in chemical biology allows for the development of innovative therapeutic strategies through the modulation of protein levels within cells. -
PROTAC Linker
Azido-PEG6-azide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring an azide functional group, it facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, making it a versatile tool for targeted protein degradation studies. -
PROTAC Linkers
Bis-PEG12-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, facilitating the targeted degradation of specific proteins within cells. Bis-PEG12-acid is ideal for research applications focused on proteostasis, targeted therapy development, and the study of protein function through degradation mechanisms. -
PROTAC Linkers
m-PEG7-alcohol is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the development of innovative therapeutic strategies by linking target proteins to E3 ligases, enhancing protein degradation. Its unique structure offers improved solubility and biocompatibility, making it suitable for various chemical biology applications. This linker is essential for researchers aiming to manipulate protein levels within cellular environments. -
PROTAC Linkers
HO-PEG11-OH is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the effective conjugation of target proteins to E3 ligases, enhancing the recruitment and degradation of specific proteins via the ubiquitin-proteasome pathway. HO-PEG11-OH is valuable in research applications focusing on targeted protein degradation, therapeutic development, and cellular signaling studies. -
PROTAC Linker
Mal-PEG8-acid is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis, facilitating targeted protein degradation. This compound enhances the solubility and stability of PROTACs while promoting efficient cellular uptake. It is a valuable tool in chemical biology for studying protein interactions and developing therapeutic agents targeting specific proteins for degradation. -
PROTAC Linkers
Amino-PEG6-amine is a polyethylene glycol (PEG) compound featuring a six-unit linker that serves as an essential component in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, enabling selective degradation pathways. This reagent is crucial for advancing research in targeted protein degradation and protein engineering applications. -
PROTAC Linker
Azide-PEG4-Tos is a PEG-based PROTAC linker known for facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide functional group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives. This compound is valuable for researchers focusing on targeted protein degradation and drug development through the innovative PROTAC technology. -
PROTAC Linkers
Biotin-PEG4-SH is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the conjugation of biotin to target proteins, enabling targeted degradation through the ubiquitin-proteasome pathway. Its primary applications include the development of novel PROTACs for targeted protein modulation in various biological studies and therapeutic investigations. -
PROTAC Linker
Biotin-PEG-Biotin is a polyethylene glycol (PEG) linkage compound designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This bifunctional linker enhances the solubility and bioavailability of target proteins, facilitating efficient degradation through the ubiquitin-proteasome system. Its primary applications include the development of novel therapeutic agents for targeted protein degradation in various diseases, including cancer and neurodegenerative disorders. -
PROTAC Linker
Thiol-PEG3-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). Its thiol moiety provides a reactive site for conjugation, facilitating the development of novel therapeutics that leverage targeted degradation mechanisms. This compound is essential for enhancing the solubility and stability of PROTACs, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Amino-PEG12-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It facilitates the selective degradation of target proteins by linking an E3 ligase ligand with a target protein binder. This reagent is valuable for research applications in targeted protein degradation and developing novel therapeutic strategies. -
PROTAC Linker
m-PEG5-acid is a polyethylene glycol-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the formation of PROTACs and promoting targeted protein degradation. m-PEG5-acid is instrumental in advancing research in protein modulation and therapeutic development. -
PROTAC Linker
Diethylene glycol bis(p-toluenesulfonate) is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins by bridging an E3 ligase and a protein of interest, enabling the selective modulation of cellular pathways. Its application is particularly relevant in drug discovery and development aimed at treating diseases associated with protein dysregulation. -
PROTAC Linkers
Boc-NH-PEG6-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins and E3 ligases, thereby enabling targeted protein degradation. It is essential for researchers developing PROTACs to study protein function and regulation in various biological contexts. -
PROTAC Linker
tert-Butyl 5-bromoisoindoline-2-carboxylate serves as a PROTAC linker, facilitating targeted protein degradation mechanisms. This compound is instrumental in synthesizing various PROTACs, including the HSD17B13 degrader 1, which enables the modulation of protein levels within biological systems. Its structural properties make it a valuable tool in research applications focused on targeted therapy development and protein regulation studies. -
PROTAC Linker
t-Boc-N-amido-PEG5-acetic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a terminal carboxylic acid, facilitating conjugation with targeting ligands and degradation tags. It exhibits key biological activity in promoting targeted protein degradation, making it a valuable tool in drug discovery and development research applications. -
PROTAC Linker
3-Iodopropan-1-ol is a PROTAC linker characterized by its role in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligase, promoting their ubiquitination and subsequent degradation. It is a valuable tool in research applications aimed at exploring targeted protein degradation and elucidating cellular pathways. -
PROTAC Linker
m-PEG7-thiol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound exhibits excellent solubility and flexibility, facilitating the efficient conjugation of target proteins with E3 ligases. It serves as a crucial component in the development of novel therapeutic modalities that harness the ubiquitin-proteasome system for targeted protein degradation in various research applications. -
PROTAC Linker
Tetrazine-Ph-NHCO-C3-NHS ester serves as a PEG-based PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a Tetrazine group that enables a selective inverse electron demand Diels-Alder reaction (iEDDA) with TCO-containing molecules. It is instrumental in developing targeted protein degradation strategies in chemical research, enhancing the precision of therapeutic interventions. -
PROTAC Linker
Fmoc-NH-PEG8-NHS ester is a polyethylene glycol (PEG) linker designed for use in PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. Its long PEG chain improves solubility and bioavailability, making it a valuable tool in chemical biology and drug discovery applications focused on modulating protein levels within cells. -
PROTAC Linker
Amino-PEG2-C2-hydrazide-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient conjugation of target proteins to E3 ligases, enhancing the degradation of specific proteins through the ubiquitin-proteasome pathway. Its versatile structure allows for a variety of applications in chemical biology and drug discovery, particularly in targeted protein degradation research. -
PROTAC Linker
DBCO-PEG3-NHS is a PROTAC linker featuring an alkynyl (DBCO) and N-hydroxysuccinimide (NHS) ester group, facilitating the chemical modification of proteins and antibodies. This reagent is instrumental in the synthesis of PROTACs, enhancing targeted protein degradation applications, as well as contributing to drug delivery systems and the development of biosensors and diagnostic assays. It allows for precise conjugation chemistry, enabling innovative research in therapeutic development and biomolecular interactions. -
PROTAC Linkers
Biotin-PEG8-amine is a biotinylated linker with a polyethylene glycol (PEG) moiety designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound enhances the solubility and stability of PROTAC molecules, facilitating targeted protein degradation in cellular studies. Its biotin functionality also allows for efficient capture and purification of PROTACs via streptavidin-based methods, enabling exploration of protein interactions and functional assays in chemical biology. -
PROTAC Linker
Azido-PEG10-NHS ester is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for chemical biology applications. -
PROTAC Linker
Tert-Butyl 8-hydroxyoctanoate functions as a PROTAC linker, facilitating the synthesis of various PROTACs, including PROTAC CDK Degrader-1. This compound exhibits potent anti-tumor activity through targeted degradation of cyclin-dependent kinases (CDKs), making it a valuable tool for cancer research and therapeutic development. Its role in PROTAC design enhances the specificity and efficacy of targeted protein degradation strategies. -
PROTAC Linker
Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation molecular constructs. This compound features a tetrazine moiety that facilitates click chemistry via an inverse electron demand Diels-Alder reaction (iEDDA) with trans-cyclooctene (TCO) derivatives. Its biological activity allows for the selective recruitment of E3 ligases, making it a valuable tool for researchers studying protein regulation and degradation pathways. This reagent is essential for the development of innovative therapies utilizing PROTAC technology. -
PROTAC Linker
Bromo-PEG3-C2-acid is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the formation of PROTACs by providing a suitable structure for the recruitment of E3 ligases and target proteins, enabling targeted degradation in cellular systems. It is suitable for use in research applications focused on protein degradation and modulation of cellular pathways. -
PROTAC Linker
Aminooxy-PEG1-propargyl is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. Featuring an alkyne group, it facilitates click chemistry and can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for precise conjugation with azide-containing molecules. This compound is valuable for researchers engaged in the development of targeted protein degradation strategies. Its versatility makes it an essential tool for advancing chemical biology applications. -
PROTAC Linker
HS-PEG5-CH2CH2NH2 hydrochloride is a PROTAC linker designed to facilitate the degradation of target proteins via the proteasome pathway. As part of the polyethylene glycol (PEG) class, this compound provides favorable solubility and biocompatibility, making it an ideal choice for synthesizing PROTAC molecules. Its application supports studies in targeted protein degradation and therapeutic development in various diseases. -
PROTAC Linker
(9H-Fluoren-9-yl)methyl (3-aminopropyl)carbamate hydrochloride serves as a PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound plays a crucial role in the synthesis of PROTAC molecules, enabling the selective recruitment of E3 ubiquitin ligases to target proteins for ubiquitination and subsequent degradation. Its application in research is essential for advancing studies in targeted protein modulation and therapeutic interventions in various diseases. -
PROTAC Linker
Bis(2,5-dioxopyrrolidin-1-yl) succinate serves as a versatile PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the precision and efficacy of targeted protein degradation by promoting the recruitment of E3 ubiquitin ligases to specific protein targets. Its application in chemical biology allows for the investigation of protein dynamics and modulation of cellular pathways for therapeutic development. -
PROTAC Linker
10-Aminodecan-1-ol is a versatile PROTAC linker utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). Its structure facilitates the efficient conjugation of target proteins to E3 ligases, enabling targeted degradation pathways. This compound is essential for researchers focusing on targeted protein degradation and related therapeutic applications. -
PROTAC Linker
Fmoc-NH-PEG2-C2-NH2 hydrochloride is a PROTAC linker designed to facilitate the synthesis of PROTAC compounds. This bifunctional molecule enables the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. Its applications extend to chemical biology and drug discovery, allowing researchers to explore novel therapeutic strategies through the modulation of protein levels within cellular systems. -
PROTAC Linker
(4-(((tert-Butoxycarbonyl)amino)methyl)phenyl)boronic acid functions as a PROTAC linker, facilitating the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound is crucial for achieving selective degradation of target proteins, thereby enabling studies in targeted protein modulation and therapeutic development. Its robust chemical properties make it suitable for advancing research in protein homeostasis and cellular regulation. -
PROTAC Linker
Ethyl 3-bromopropanoate is a versatile PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the construction of bifunctional molecules that promote targeted degradation of specific proteins, thereby providing a powerful tool for studying protein function and regulation. Its application in chemical biology may enhance the development of therapeutics aimed at previously undruggable targets. -
PROTAC Linker
2-(Prop-2-yn-1-yloxy)tetrahydro-2H-pyran serves as a versatile linker for PROTAC (Proteolysis-Targeting Chimera) synthesis. This compound facilitates the functionalization of target proteins through targeted protein degradation, offering significant potential in therapeutic research and drug development. It is particularly valuable in studies focused on the modulation of protein expression and the development of novel biotherapeutics. -
PROTAC Linker
1'-(tert-Butoxycarbonyl)-[1,4'-bipiperidine]-4-carboxylic acid is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs by connecting E3 ligases and target proteins, thereby promoting targeted protein degradation. It is valuable in various research applications, including drug discovery and molecular biology studies focused on protein regulation and degradation pathways. -
PROTAC Linker
Benzyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate serves as a PROTAC linker that is crucial for the design and synthesis of targeted protein degradation (TPD) bioconjugates. This compound facilitates the conjugation of E3 ligase recruiting elements to target proteins, thereby enabling the degradation of unwanted proteins within cells. Its structural characteristics make it a valuable tool for researchers exploring the therapeutic potential of PROTAC technology in various diseases. -
PROTAC Linker
2-((tert-Butoxycarbonyl)amino)ethyl 4-methylbenzenesulfonate serves as a PROTAC linker essential for the construction of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of proteins, enabling researchers to modulate cellular processes by selectively eliminating specific proteins of interest. Its application in PROTAC synthesis supports studies in drug discovery and the development of innovative therapeutic strategies. -
PROTAC Linker
Methyl 4-(2-hydroxyethyl)benzoate serves as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound is integral in the design of bifunctional molecules that promote targeted degradation of specific proteins, thereby enabling the study of protein function and the development of therapeutic strategies. Its utility in the synthesis of advanced PROTAC structures enhances research applications in cellular biology and drug discovery. -
PROTAC Linker
tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate serves as a key linker in the development of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing protein degradation pathways. It is suitable for applications in targeted protein degradation research, enabling the exploration of therapeutic strategies for various diseases by modulating protein levels within cells. -
PROTAC Linker
2-(4-Cyanophenyl)acetic acid functions as a versatile PROTAC linker, integral to the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of heterobifunctional molecules that induce ubiquitin-mediated degradation of target proteins, enabling selective modulation of protein levels. Its application in chemical biology research supports the development of targeted therapies and enhances investigations into protein degradation pathways. -
PROTAC Linker
Boc-bipiperidine-NH2 serves as a PROTAC linker, facilitating the development of targeted protein degraders. This reagent is crucial in constructing bifunctional molecules that engage specific E3 ligases and target proteins for degradation. Its application in PROTAC synthesis opens avenues for innovative therapeutic strategies aimed at modulating protein levels in various biological pathways. -
PROTAC Linker
14-Hydroxytetradecanoic acid is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation, an essential mechanism in the study of proteostasis and disease modulation. Its role in linking ligands to E3 ligase components makes it a valuable tool for researchers investigating therapeutic strategies in cancer and other diseases. -
PROTAC Linker
tert-Butyl (4-aminobutyl)carbamate hydrochloride is a PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the design of bifunctional molecules that promote targeted degradation of proteins, enabling advanced studies in cellular signaling and protein homeostasis. Its use in the development of selective proteolysis tools enhances the potential for therapeutic interventions in a variety of diseases through targeted protein modulation. -
PROTAC Linker
tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate is a versatile PROTAC linker utilized for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligand-recruiting units to E3 ligase components, enabling targeted protein degradation. Its application in chemical biology research supports the development of novel therapeutic strategies by enhancing the specificity and efficacy of PROTAC formulations.
