Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Mal-amido-PEG9-acid is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of bifunctional molecules that can induce targeted protein degradation, thereby providing a novel approach for modulating protein levels in research applications. Its unique structure enhances solubility and biocompatibility, making it a valuable tool for drug discovery and development in various biological studies. -
PROTAC Linker
Methyl 9-bromononanoate is a versatile PROTAC linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the construction of bifunctional molecules that promote the degradation of target proteins through the ubiquitin-proteasome system. This reagent is crucial for research applications aimed at elucidating protein function and therapeutic intervention in disease models. -
PROTAC Linker
Pent-4-ynal is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). By enabling the conjugation of target proteins to E3 ligases, it enhances the selective degradation of specific proteins within cellular pathways. This compound is valuable for research applications focused on targeted protein degradation and the exploration of therapeutic options in oncology and other diseases. -
PROTAC Linker
2-(3-((Tert-butoxycarbonyl)amino)cyclobutyl)acetic acid serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficacy of protein degradation by linking target proteins with E3 ligases, enabling selective modulation of protein levels. It is valuable for research applications focusing on targeted protein degradation and therapeutic development. -
PROTAC Linker
N-Boc-N-methyl-3-chloro-1-propanamine is a PROTAC linker designed for the synthesis of PROTAC compounds. This reagent enables the construction of bifunctional molecules that can facilitate targeted protein degradation. It is instrumental in research applications focusing on the modulation of protein levels and the exploration of new therapeutic strategies in various disease models. -
PROTAC Linkers
β-Estradiol-6-one 6-(O-carboxymethyloxime) is a PROTAC linker designed for targeted protein degradation. This compound facilitates the development of PROTACs by providing a suitable moiety for conjugation with E3 ligases and target proteins. Its unique structure enables efficient cellular uptake and promotes the degradation of specific proteins, making it valuable for research in biopharmaceuticals and therapeutic applications. -
PROTAC Linker
tert-Butyl (10-bromodecyl)carbamate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial for creating bifunctional molecules that can selectively induce the degradation of specific proteins, enhancing the study of protein function and regulation. Its robust chemical properties make it an essential tool in targeted protein degradation research and related applications. -
PROTAC Linker
3-(Piperazin-1-yl)propan-1-ol serves as a key linker in PROTAC (Proteolysis Targeting Chimeras) synthesis. Its structure permits effective conjugation of ligand components necessary for targeted protein degradation. This compound is essential in research applications focused on the development and optimization of PROTAC-based therapeutic agents. -
PROTAC Linker
12-(Benzyloxy)-12-oxododecanoic acid serves as an effective PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the design of targeted protein degradation systems, enabling selective regulation of protein levels in cellular research. Its utility spans various applications in drug discovery and development, particularly in studies aiming to innovate therapeutic strategies through targeted protein modulation. -
PROTAC Linker
6-Bromohexanenitrile is a chemical linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This linker provides a functional handle for conjugating various target ligands, facilitating the selective degradation of specific proteins within cellular contexts. It plays a crucial role in enhancing the efficacy of targeted protein degradation strategies in pharmaceutical research and drug discovery. -
PROTAC Linker
4-(4-Boc-Piperazino)benzylamine functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for the construction of bifunctional molecules that degrade specific disease-related proteins via the ubiquitin-proteasome pathway. It plays a crucial role in targeted protein degradation research and in the design of innovative therapeutic strategies. -
PROTAC Linker
Boc-3,3'-biazetidine hemioxalate is a PROTAC linker designed for the synthesis of PROTAC molecules. This compound facilitates the effective recruitment of E3 ligases, enhancing targeted protein degradation. Its application in drug discovery research allows for the development of innovative therapeutic strategies aimed at modulating protein levels within cells. -
PROTAC Linker
Boc-C17-COOH is a PROTAC (Proteolysis Targeting Chimeras) linker that facilitates the synthesis of PROTACs, enabling targeted protein degradation. Its chemical structure supports the effective conjugation of target proteins and E3 ligases, making it a valuable tool for research in protein homeostasis and regulation. This linker plays a crucial role in advancing studies on targeted therapeutics and the development of innovative treatments for various diseases. -
PROTAC Linker
Methyl 8-bromooctanoate serves as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs) that can selectively degrade target proteins. This compound plays a crucial role in expanding the toolbox for targeted protein degradation research and therapeutic applications. Its unique structure enhances the potency and specificity of PROTACs in various biological assays. -
PROTAC Linker
3-(4-Bromobenzoyl)propionic acid serves as a PROTAC linker, facilitating the synthesis of targeted protein degradation compounds. This reagent is essential for creating bifunctional molecules that promote the ubiquitination and subsequent degradation of specific proteins, enabling studies on protein function and regulation. Researchers can utilize this compound in drug discovery and development processes focusing on targeted therapy. -
PROTAC Linker
Methyl 4-hydroxybicyclo[2.2.2]octane-1-carboxylate is a PROTAC linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound enables selective degradation of target proteins through targeted ubiquitination, playing a crucial role in modulating cellular pathways. Its application in PROTAC synthesis allows researchers to explore innovative therapeutic strategies in cancer and various diseases by harnessing the power of targeted protein degradation. -
PROTAC Linker
4-(2-((tert-Butoxycarbonyl)amino)ethyl)benzoic acid functions as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the development of targeted protein degradation strategies, which have significant implications in cancer research and other fields of therapeutic discovery. Researchers utilize this linker to enhance the specificity and efficacy of PROTACs in modulating protein levels within cellular systems. -
PROTAC Linker
Benzyl (4-hydroxybutyl)carbamate serves as a PROTAC linker designed for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent linkage of target proteins to E3 ligases, promoting targeted protein degradation. It is essential for advancing research in targeted therapies and unraveling protein function in cellular processes. -
PROTAC Linker
Cbz-PEG2-prop-1-yne is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). By connecting target proteins to E3 ligases, this compound enhances targeted protein degradation, making it a valuable tool in the study of protein function and regulation. Its application in drug discovery and development enables researchers to explore novel therapeutic strategies for various diseases. -
PROTAC Linker
Methyl 5-bromo-4-oxopentanoate is a chemical linker designed for use in the development of Proteolysis Targeting Chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs, facilitating the targeted degradation of proteins by recruiting an E3 ligase. It is essential for researchers investigating targeted protein degradation and exploring therapeutic avenues in cancer and other diseases. -
PROTAC Linkers
Thiol-PEG6-alcohol is a poly(ethylene glycol)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features a thiol group that facilitates conjugation and linkage with targeted proteins, enhancing the delivery and degradation of specific intracellular proteins. It is a valuable reagent for researchers developing novel PROTACs for targeted protein degradation in therapeutic applications. -
PROTAC Linker
Methyl 1-(5-Bromopyrimidin-2-yl)piperidine-4-carboxylate is a key linker utilized in the design and synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. It facilitates targeted protein degradation by connecting ligand and E3 ligase components in PROTACs. This compound is essential for advancing research in targeted therapies and studying protein interactions and degradation pathways. -
PROTAC Linker
tert-Butyl 4-(azetidin-3-yl)piperazine-1-carboxylate hydrochloride is a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by linking them to E3 ligases, thereby allowing for targeted therapeutic applications. Its utility in PROTAC synthesis supports research in various fields, including cancer biology and drug discovery. -
PROTAC Linker
tert-Butyl N-[3-(hydroxymethyl)cyclobutyl]carbamate serves as a PROTAC linker, facilitating the effective synthesis of proteolysis targeting chimeras (PROTACs). Its unique structural characteristics improve the conjugation efficiency and stability of the resultant PROTACs. This compound is essential for researchers investigating targeted protein degradation and exploring new therapeutic strategies in various disease models. -
PROTAC Linkers
5-Ethynyl-2'-deoxyuridine (EdU) is a thymidine analogue that serves as a vital tool in cell proliferation studies. This compound can be incorporated into cellular DNA during replication and subsequently reacts with a fluorescent azide through a copper-catalyzed azide-alkyne cycloaddition (CuAAc) “Click” reaction, allowing for advanced imaging techniques. EdU also functions as an alkyl chain-based linker for the synthesis of PROTACs, facilitating targeted protein degradation in research applications. Its unique properties make it essential for investigations in cellular dynamics and innovative therapeutic strategies. -
PROTAC Linker
DBCO-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise bioconjugation. Its application is critical in the development of targeted protein degradation strategies, enhancing the ability to study protein interactions and manipulate cellular processes. -
PROTAC Linker
Biotin-PEG3-azide is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, facilitating the development of targeted protein degradation strategies. Biotin-PEG3-azide is essential for advancing research in molecular biology and therapeutic development involving PROTAC technology. -
PROTAC Linkers
L-Azidohomoalanine hydrochloride is a versatile PROTAC linker featuring an azide functional group, facilitating the synthesis of protein-targeting chimeras. This compound demonstrates key click chemistry capabilities, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when paired with DBCO or BCN groups, making it invaluable for bioconjugation and drug discovery applications. -
PROTAC Linker
4-Bromobutanoic acid tert-butyl ester functions as a PROTAC linker, facilitating the synthesis of PROTACs for targeted protein degradation. This compound plays a critical role in modulating protein levels within cells, enabling the study of protein function and potential therapeutic developments. Its incorporation into PROTACs aids in the design of innovative approaches for drug discovery and development in cancer and other diseases. -
PROTAC Linker
N-Boc-4,4'-bipiperidine is a versatile PROTAC linker that facilitates the design and synthesis of targeted protein degraders. This compound enables the construction of PROTACs such as BRD9 Degrader-5, which are crucial for modulating protein levels through the ubiquitin-proteasome system. Its role in the development of molecular probes for selective degradation highlights its significance in chemical biology and therapeutic research applications. -
PROTAC Linker
2-Chloroethanamine hydrochloride is a PROTAC linker utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound plays a crucial role in connecting target proteins to E3 ligases, facilitating targeted protein degradation. It is widely employed in chemical biology for the development of innovative therapeutics that leverage the ubiquitin-proteasome system. -
PROTAC Linker
3-Mercaptopropionic acid NHS ester functions as a linker in PROTAC (Proteolysis Targeting Chimeras) technology, facilitating the conjugation of target proteins for degradation. This reagent enables the synthesis of innovative PROTACs by providing a reactive moiety for efficient attachment to both the ubiquitin ligase and the target protein. Its unique structure supports targeted proteolysis and enhances the specificity and efficacy of therapeutic interventions in protein homeostasis research. -
PROTAC Linker
Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its versatile chemical reactivity makes it suitable for developing targeted protein degradation strategies in chemical biology research and drug discovery applications. -
PROTAC Linkers
Ac4GalNAz is an alkyl chain-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Ac4GalNAz serves as an essential tool in the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
m-PEG3-aldehyde is a polyethylene glycol (PEG)-based linker designed specifically for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances solubility and facilitates the development of bifunctional molecules that can simultaneously engage a target protein and an E3 ligase. Its application is crucial for advancing research in targeted protein degradation strategies and drug discovery. -
PROTAC Linkers
EGNHS is an alkyl/ether-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the construction of bifunctional molecules that can selectively target and degrade specific proteins in cellular systems. EGNHS is valuable for research applications focused on targeted protein degradation and the development of novel therapeutic strategies in various disease contexts. -
PROTAC Linkers
Biotin-PEG4-NHS ester is a biotinylated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the targeted degradation of specific proteins within cells. Its unique structure promotes solubility and improves the stability of PROTACs, making it a valuable tool for drug discovery and development in molecular biology and therapeutic research. -
PROTAC Linker
Amino-PEG3-C2-Azido is a PEG-based linker designed for use in PROTAC applications, facilitating the synthesis of targeted protein degraders, such as the PARP1 degrader iRucaparib-TP3. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds, making it a versatile tool for chemical biology and drug discovery research. -
PROTAC Linker
L-Homopropargylglycine is an alkyne-containing amino acid analog of methionine designed for use as a PROTAC linker. This compound facilitates the synthesis of PROTACs by enabling robust click chemistry reactions with azide-functionalized partners, such as Alexa Fluor. Its unique structure allows for precise manipulation of target protein degradation pathways, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linkers
Biotin alkyne is a PEG-based linker designed for the synthesis of PROTACs, targeting the ubiquitin-proteasome system. As a click chemistry reagent, it features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. This functionality facilitates the efficient assembly of bifunctional degraders, advancing research in targeted protein degradation and therapeutic development. -
PROTAC Linker
Biotin-PEG4-azide is a biotin-labeled PEG-based linker designed for constructing PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, Biotin-PEG4-azide can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds, facilitating advanced applications in targeted protein degradation research. -
PROTAC Linker
Biotin-PEG4-alkyne is a biotin-functionalized linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. This PEG-based compound features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the efficient conjugation with azide-containing molecules. Its application is vital in developing PROTACs for targeted protein degradation studies and therapeutic interventions. -
PROTAC Linker
Azido-PEG4-NHS-ester is a PEG-based linker designed for PROTAC synthesis, functioning primarily through click chemistry mechanisms. This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition reactions with DBCO or BCN groups. Its unique properties make it a valuable tool for researchers focused on the development of targeted protein degradation strategies. -
PROTAC Linkers
N-Boc-piperazine is a versatile alkyl/ether-based linker utilized in the synthesis of PROTACs, specifically for the development of PD-1/PD-L1 degrader-1. Its unique structure facilitates the formation of bifunctional molecules, enabling targeted protein degradation. This compound is essential for research applications focused on enhancing cancer immunotherapy and understanding the mechanisms of targeted protein modulation. -
PROTAC Linker
2-Boc-2,6-Diazaspiro[3.3]heptane is a versatile PROTAC linker facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a critical component in the development of targeted protein degradation strategies, enabling the selective modulation of protein levels within biological systems. Its structural attributes make it suitable for various applications in chemical biology and drug discovery research. -
PROTAC Linkers
Alkynyl myristic acid is a PROTAC linker characterized by its alkyl chain structure. It serves as a versatile click chemistry reagent, featuring an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. This compound is essential for the synthesis of PROTACs, facilitating targeted protein degradation studies in various biological research applications. -
PROTAC Linker
Mal-PEG8-NHS ester is a PEG-based PROTAC linker that facilitates the conjugation of target proteins for targeted protein degradation applications. This compound possesses a maleimide functional group, allowing for site-specific linking to thiol-containing biomolecules. It is essential for the synthesis of PROTACs aimed at modulating protein levels within cells, making it a valuable tool in drug discovery and development research. -
PROTAC Linker
TCO-PEG4-NHS ester is a PEG-based linker utilized in the synthesis of PROTACs. Its primary mechanism involves click chemistry, specifically the inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. TCO-PEG4-NHS ester facilitates targeted protein degradation, making it a valuable tool for research applications in pharmacology and molecular biology, particularly in the development of novel therapeutics. -
PROTAC Linker
Sulfo-NHS-Acetate is a PROTAC linker that enables the synthesis of proteolysis-targeting chimeras (PROTACs) through the formation of stable amide bonds. This compound features an alkyl chain that facilitates the conjugation of various target proteins, enhancing the efficacy of targeted protein degradation. It serves as an essential building block for researchers aiming to develop innovative therapeutics in targeted protein modulation and degradation studies. -
PROTAC Linker
Methyltetrazine-Ph-NHS ester is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a tetrazine group that participates in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) moieties. Its key biological activity lies in enabling targeted protein degradation, providing a valuable tool for researchers exploring protein function and dynamics in cellular systems. Methyltetrazine-Ph-NHS ester is suitable for applications in chemical biology and drug discovery research.
