Fig. 1 · Structure
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3-Mercaptopropionic acid NHS ester
PROTAC Linker
3-Mercaptopropionic acid NHS ester functions as a linker in PROTAC (Proteolysis Targeting Chimeras) technology, facilitating the conjugation of target proteins for degradation. This reagent enables the synthesis of innovative PROTACs by providing a reactive moiety for efficient attachment to both the ubiquitin ligase and the target protein. Its unique structure supports targeted proteolysis and enhances the specificity and efficacy of therapeutic interventions in protein homeostasis research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 117235-10-6 |
| Applications | PROTAC Linker |
| Formula | C7H9NO4S |
| Molecular Weight | 203.22 |
| SMILES | O=C(ON1C(CCC1=O)=O)CCS |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.