Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Fmoc-PEG5-NHS ester is a polyethylene glycol (PEG) linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins with E3 ligases, thereby promoting targeted protein degradation. Fmoc-PEG5-NHS ester is particularly valuable in research applications involving selective modulation of protein levels and the study of cellular pathways. -
PROTAC Linkers
Azido-PEG8-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. This reagent features an azide group, enabling its engagement in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can facilitate strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when paired with DBCO or BCN functionalized compounds, making it a versatile tool for bioconjugation in chemical biology research. -
PROTAC Linkers
Thiol-PEG4-NH2 hydrochloride is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a thiol group which facilitates the conjugation to target proteins, enhancing the development of targeted degradation strategies. It serves as a crucial component in creating PROTACs for studying protein regulation and degradation pathways in cellular models. -
PROTAC Linkers
Bromoacetamido-PEG3-azide is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. The versatility of Bromoacetamido-PEG3-azide makes it a valuable tool for chemical biology and therapeutic development. -
PROTAC Linker
(+)–Biotin-SLC is a bifunctional linker designed for PROTAC synthesis, characterized by an alkyl chain structure. It facilitates the conjugation of biotin to a target protein, enabling the targeted degradation of proteins via the ubiquitin-proteasome pathway. This reagent is valuable for researchers exploring selective protein modulation and degradation mechanisms in cellular studies. -
PROTAC Linkers
TCO-PEG6-amine is a PEG-derived linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This linker facilitates the development of bifunctional molecules to selectively degrade target proteins via the ubiquitin-proteasome system. Its unique structure enables effective conjugation with other moieties, contributing to research applications in targeted protein degradation and molecular biochemistry. -
PROTAC Linkers
Tos-PEG6-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of functional PROTAC molecules, enabling targeted protein degradation. Its use is crucial in developing novel therapeutic strategies aimed at modulating protein levels in various biological contexts. -
PROTAC Linkers
Biotin-nPEG-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the efficient conjugation of target proteins with E3 ligases, enhancing the selective degradation of specific proteins within cellular environments. It is essential for researchers aiming to study protein degradation pathways and investigate therapeutic approaches in chemical biology. -
PROTAC Linker
Cbz-NH-PEG3-C2-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a carbobenzyloxy (Cbz) protecting group and a three-unit polyethylene glycol (PEG) spacer, facilitating optimal conjugation and stability. Its application is pivotal in the development of targeted protein degradation strategies, enhancing the efficacy of drug discovery efforts in various therapeutic areas. -
PROTAC Linker
m-PEG5-CH2CH2COOH is a polyethylene glycol (PEG) linker designed for use in PROTAC (PROteolysis TArgeting Chimera) synthesis. It facilitates the conjugation of ligands to E3 ligase recruiters, enhancing targeted protein degradation mechanisms. This reagent is crucial for the development of bifunctional molecules in drug discovery and research applications focused on modulating protein levels within cells. -
PROTAC Linkers
Azido-PEG24-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG24-acid is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool in chemical biology and protein degradation research applications. -
PROTAC Linker
Bis-PEG4-PFP ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the effective conjugation of target proteins to E3 ligases, enhancing protein degradation through the ubiquitin-proteasome system. Its versatile application in chemical biology makes it an essential tool for researchers exploring targeted protein degradation and therapeutic development. -
PROTAC Linker
Thiol-PEG3-acetic acid is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of specific proteins within cellular environments. Its application is crucial in developing PROTACs for targeted protein degradation studies and therapeutic research. -
PROTAC Linker
Bromoacetamido-PEG4-NHS ester is a PEGylated linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. Its applications extend to chemical biology and drug discovery, where it aids in the development of innovative therapeutic strategies by modulating protein expression levels. -
PROTAC Linkers
m-PEG24-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves enhancing the solubility and stability of the PROTAC molecules, facilitating their ability to induce targeted protein degradation. This compound is particularly valuable in drug discovery and development applications focused on selective modulation of protein targets. -
PROTAC Linker
Benzyl-PEG7-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by linking E3 ligases to proteins of interest. It is valuable for researchers exploring targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linkers
Boc-amido-PEG9-amine is a polyethylene glycol (PEG)-based linker tailored for PROTAC (Proteolysis Targeting Chimeras) applications. This reagent facilitates the synthesis of PROTAC molecules, enabling targeted protein degradation through an innovative dual-binding mechanism. Its hydrophilic nature enhances solubility and bioavailability, making it an essential component in the development of targeted therapeutics. -
PROTAC Linkers
Boc-C16-NHS ester is an alkyl/ether-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This molecule facilitates the selective degradation of target proteins by promoting the interaction between E3 ubiquitin ligases and the protein of interest. Its ability to enhance the efficacy of PROTACs makes it a valuable reagent in chemical biology and drug discovery research. -
PROTAC Linker
Diazo Biotin-PEG3-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its applications extend to the development of targeted protein degradation methods, facilitating the exploration of protein interactions and degradation pathways in chemical biology research. -
PROTAC Linker
DBCO-PEG3-amine is a PEG-based linker designed for use in PROTAC synthesis. This compound features a DBCO group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its application in the development of bifunctional degraders positions DBCO-PEG3-amine as a valuable tool in chemical biology research, particularly for targeted protein degradation studies. -
PROTAC Linker
Fmoc-PEG2-C2-NHS ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This NHS ester enables efficient conjugation to target proteins, enhancing cellular uptake and stability of the resulting PROTACs. It is suitable for research applications in targeted protein degradation and modular drug design, facilitating investigations into protein regulation and therapeutic development. -
PROTAC Linker
Maleimide-C10-NHS ester is a versatile linker designed for use in protein-targeting chimeras (PROTACs) to facilitate targeted protein degradation. This alkyl/ether-based compound allows for efficient conjugation to proteins, enhancing the specificity and efficacy of therapeutic applications. It serves as a vital component in the development of novel PROTACs for research into cellular regulation, protein interactions, and disease mechanisms. -
PROTAC linker
NH-bis(PEG2-propargyl) is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an alkyne moiety that enables the copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction with azide-containing molecules. Its function as a versatile click chemistry reagent facilitates the development of targeted protein degradation strategies, making it valuable for research in targeted therapeutics and cellular signaling pathways. -
PROTAC Linker
Benzyl-PEG4-Ots is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the formation of PROTACs by providing a stable link that enhances the molecular interaction between a target protein and an E3 ligase. This compound is pivotal in research applications aimed at targeted protein degradation, enabling studies in cellular biology, therapeutic development, and the manipulation of protein levels in various disease models. -
PROTAC Linkers
DNP-PEG4-DBCO is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound serves as a click chemistry reagent, featuring a DBCO group that participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique properties make it suitable for developing targeted protein degradation strategies in various biological research applications. -
PROTAC Linkers
Biotin-PEG4-TFP ester is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of proteins and enables targeted protein degradation through the recruitment of E3 ligases. Its application is pivotal in the development of innovative therapeutic strategies for selective modulation of protein levels in various biological contexts. -
PROTAC Linkers
m-PEG5-Br is a PEG-based linker designed for PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the development of bifunctional molecules by promoting targeted protein degradation through the recruitment of E3 ubiquitin ligases. m-PEG5-Br serves as a versatile building block for the synthesis of novel PROTACs, advancing research in targeted therapy and protein regulation studies. -
PROTAC Linkers
Biotin-PEG11-azide is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its biotinylated structure allows for high-affinity interactions with streptavidin or avidin, making it a valuable tool in chemical biology and proteomics applications. -
PROTAC Linker
HO-PEG13-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This linker facilitates the conjugation of target proteins to E3 ligases, enabling controlled degradation pathways. Its solubility and flexibility enhance the effectiveness of PROTACs in various biological assays and contribute to the advancement of targeted protein degradation research. -
PROTAC Linker
Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker that facilitates the synthesis of PROTAC molecules. This compound serves as a key building block in the development of targeted protein degradation strategies, enabling the selective modulation of protein levels in cellular systems. It is particularly useful in research applications focused on enhancing therapeutic efficacy through innovative drug design. -
PROTAC Linker
Me-PEG4-Me is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of target ligands to E3 ligase ligands, enabling the development of innovative targeted protein degradation strategies. Me-PEG4-Me's hydrophilic nature enhances solubility and biocompatibility, making it suitable for various research applications in the field of protein regulation and degradation. -
PROTAC Linkers
DSPE-PEG2-mal is a PEG-derived linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the assembly of the requisite components for targeted protein degradation, enhancing the solubility and bioavailability of the resulting PROTACs. It is instrumental in research applications aimed at modulating protein levels for therapeutic purposes. -
PROTAC Linkers
DBCO-PEG2-acid is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. Featuring a DBCO group, it enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is essential for the development of targeted protein degradation strategies in chemical biology research. Its ability to form stable linkages enhances the design and application of bifunctional molecules for therapeutic development. -
PROTAC Linker
Boc-Aminooxy-PEG2 is a PEG-derived linker utilized in the construction of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins by linking an E3 ligase to a protein of interest, enabling selective ubiquitination and subsequent proteasomal degradation. It is particularly valuable in research applications focused on protein degradation, therapeutic development, and cellular signaling pathways. -
PROTAC Linkers
Azido-PEG12-NHS ester is a PEG-based linker designed for PROTAC synthesis that incorporates an azide functional group. This compound participates in click chemistry, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN substrates. It is particularly valuable in the development of targeted protein degradation strategies, facilitating innovative research applications in drug discovery and cellular biology. -
PROTAC Linker
Azido-PEG5-PFP ester serves as a versatile PROTAC linker featuring a polyethylene glycol (PEG) moiety. Its primary mechanism involves facilitating targeted protein degradation via a biocompatible linker design. This compound is suitable for the synthesis of PROTACs, enabling efficient conjugation through click chemistry techniques, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules. Its application in research supports advancements in targeted therapeutics and protein modulation. -
PROTAC Linkers
Mal-PEG2-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligase ligands to target proteins, enhancing selective degradation through the ubiquitin-proteasome pathway. It is particularly valuable in chemical biology research focused on studying protein degradation and modulation of cellular pathways. -
PROTAC linker
N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester functions as a PEG-based PROTAC linker, facilitating the synthesis of PROTACs. This compound serves as a click chemistry reagent, featuring an azide group that can engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, interacting with DBCO or BCN functionalized molecules. Its versatile reactive groups enable broad applications in chemical biology and drug development research. -
PROTAC Linkers
4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl-based PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in connecting E3 ligase recruiters to target proteins, enhancing targeted protein degradation. Its unique structure allows for flexibility and tunability, making it suitable for various applications in chemical biology and drug discovery research. -
PROTAC Linkers
FmocNH-PEG4-t-butyl ester is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of PROTACs by providing a flexible and soluble linkage between the target protein and the E3 ligase. Its use enhances the efficiency of target protein degradation, making it valuable for research in targeted protein modulation and therapeutic development. -
PROTAC Linker
m-PEG9-Br is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of specific intracellular proteins. Its application is critical in the development of targeted protein degradation strategies for drug discovery and therapeutic interventions in various diseases. -
PROTAC Linkers
NH-bis(PEG4-C2-NH-Boc) is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating the targeted degradation of proteins. Its bifunctional structure enhances the solubility and stability of PROTACs, promoting effective cellular uptake and engagement with target proteins. This compound is essential for researchers exploring protein degradation pathways and developing novel therapeutic strategies in targeted protein modulation. -
PROTAC Linker
Azido-PEG2-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups. Its application in PROTAC development allows for the effective modification of target proteins, making it a valuable tool for chemical biology research. -
PROTAC Linkers
Propargyl-PEG1-Boc is a versatile PROTAC linker featuring an alkyne functionality that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent is designed for use in click chemistry, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is particularly valuable for bioconjugation applications and the development of targeted protein degradation strategies. -
PROTAC Linker
Acid-PEG4-mono-methyl ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of protein ligands, enabling the targeted degradation of specific proteins within cellular environments. It is widely utilized in chemical biology and drug discovery applications to explore the modulation of protein function and to develop innovative therapeutic strategies. -
PROTAC Linker
Bis-propargyl-PEG11 is a PEG-based PROTAC linker designed for the efficient synthesis of PROTACs. Featuring an alkyne group, this compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the conjugation of azide-containing molecules. Bis-propargyl-PEG11 is a valuable tool for researchers developing targeted protein degradation strategies and investigating protein interactions. -
PROTAC Linker
Biotin-PEG2-C6-azide is a PEG-based linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. Featuring an azide functional group, it facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This reagent is instrumental in developing targeted protein degradation strategies and advancing research in cellular protein modulation and therapeutic discovery. -
PROTAC Linker
Boc-NH-Cyclobutane-COOH is a PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the creation of novel molecules that harness the cell's ubiquitin-proteasome system to selectively degrade target proteins. Its application in chemical biology enables researchers to explore new therapeutic strategies by modulating protein levels within cellular systems. -
PROTAC Linker
4,4'-Oxybis(butan-1-ol) is a versatile PROTAC linker that facilitates the development of PROTACs by connecting target proteins and E3 ligases to promote targeted protein degradation. Its unique structure enhances solubility and stability, making it an essential component in the design of compounds for research in targeted protein degradation therapies. This reagent is valuable for studies in cellular biology and drug discovery applications focused on protein homeostasis. -
PROTAC Linker
PEG2-bis(Alkyne) is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the construction of bifunctional molecules that selectively degrade target proteins via the ubiquitin-proteasome system. Its unique alkyne functionality enables efficient click chemistry, making it suitable for various research applications in targeted protein degradation studies and drug discovery.
