Fig. 1 · Structure
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5-Ethynyl-2'-deoxyuridine
Cell Proliferation Assay Reagent
5-Ethynyl-2'-deoxyuridine (EdU) is a thymidine analogue that serves as a vital tool in cell proliferation studies. This compound can be incorporated into cellular DNA during replication and subsequently reacts with a fluorescent azide through a copper-catalyzed azide-alkyne cycloaddition (CuAAc) “Click” reaction, allowing for advanced imaging techniques. EdU also functions as an alkyl chain-based linker for the synthesis of PROTACs, facilitating targeted protein degradation in research applications. Its unique properties make it essential for investigations in cellular dynamics and innovative therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 61135-33-9 |
| Applications | Cell Proliferation Assay Reagent |
| Formula | C11H12N2O5 |
| Molecular Weight | 252.23 |
| Synonyms | EdU |
| SMILES | O[C@H]1C[C@H](N2C(NC(C(C#C)=C2)=O)=O)O[C@@H]1CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.