5-Ethynyl-2'-deoxyuridine (EdU) is a thymidine analogue that serves as a vital tool in cell proliferation studies. This compound can be incorporated into cellular DNA during replication and subsequently reacts with a fluorescent azide through a copper-catalyzed azide-alkyne cycloaddition (CuAAc) “Click” reaction, allowing for advanced imaging techniques. EdU also functions as an alkyl chain-based linker for the synthesis of PROTACs, facilitating targeted protein degradation in research applications. Its unique properties make it essential for investigations in cellular dynamics and innovative therapeutic strategies.
5-Ethynyl-2'-deoxyuridine (EdU) is a thymidine analogue that serves as a vital tool in cell proliferation studies. This compound can be incorporated into cellular DNA during replication and subsequently reacts with a fluorescent azide through a copper-catalyzed azide-alkyne cycloaddition (CuAAc) “Click” reaction, allowing for advanced imaging techniques. EdU also functions as an alkyl chain-based linker for the synthesis of PROTACs, facilitating targeted protein degradation in research applications. Its unique properties make it essential for investigations in cellular dynamics and innovative therapeutic strategies.
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