Fig. 1 · Structure
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Biotin-PEG4-NHS ester
PROTAC Linkers
Biotin-PEG4-NHS ester is a biotinylated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the targeted degradation of specific proteins within cells. Its unique structure promotes solubility and improves the stability of PROTACs, making it a valuable tool for drug discovery and development in molecular biology and therapeutic research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 459426-22-3 |
| Applications | PROTAC Linkers |
| Formula | C25H40N4O10S |
| Molecular Weight | 588.67 |
| SMILES | O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.