Fig. 1 · Structure
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Biotin-PEG3-azide
PROTAC Linker
Biotin-PEG3-azide is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, facilitating the development of targeted protein degradation strategies. Biotin-PEG3-azide is essential for advancing research in molecular biology and therapeutic development involving PROTAC technology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 875770-34-6 |
| Applications | PROTAC Linker |
| Formula | C18H32N6O5S |
| Molecular Weight | 444.55 |
| SMILES | O=C(NCCOCCOCCOCCN=[N+]=[N-])CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.