Biotin-PEG4-azide is a biotin-labeled PEG-based linker designed for constructing PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, Biotin-PEG4-azide can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds, facilitating advanced applications in targeted protein degradation research.
Biotin-PEG4-azide is a biotin-labeled PEG-based linker designed for constructing PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, Biotin-PEG4-azide can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds, facilitating advanced applications in targeted protein degradation research.
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