Fig. 1 · Structure
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Mal-PEG8-NHS ester
PROTAC Linker
Mal-PEG8-NHS ester is a PEG-based PROTAC linker that facilitates the conjugation of target proteins for targeted protein degradation applications. This compound possesses a maleimide functional group, allowing for site-specific linking to thiol-containing biomolecules. It is essential for the synthesis of PROTACs aimed at modulating protein levels within cells, making it a valuable tool in drug discovery and development research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2055033-05-9 |
| Applications | PROTAC Linker |
| Formula | C27H42N2O14 |
| Molecular Weight | 618.63 |
| SMILES | O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN2C(C=CC2=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.