Catalog No.
Product Name
Application
Product Information
Citations
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UbcH5c inhibitor
UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. -
DUB inhibitor
EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5. -
USP2 inhibitor
ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 μM) with anti-proliferative activity.- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
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USP7/USP47 inhibitor
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively. -
Cereblon E3 Ubiquitin Ligase Modulating Agent
CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD). CC-92480 shows high affinity to cereblon, resulting in potent antimyeloma activity. -
Parkin modulators
BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. It enhances the activity of wild-type Parkin by stimulating its autoubiquitination and promotes the monoubiquitination of Miro1, with an EC50 of 0.17 μM. BIO-2007817 is a valuable tool for studying Parkin-mediated mitophagy and neurodegenerative diseases such as Parkinson's disease. -
UCH-L3 inhibitor
TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective inhibitor of neuronal ubiquitin C-terminal hydrolase UCH-L3, with an IC50 of 0.6 μM. It reduces ubiquitination of the glycine transporter GlyT2 in primary neurons from the brainstem and spinal cord, making it a valuable tool for studying neuronal ubiquitin regulation and glycinergic neurotransmission. -
PROTAC CRBN Degrader
CRBN-6-5-5-VHL is a potent and selective VHL-based PROTAC degrader targeting cereblon (CRBN), with a DC₅₀ of 1.5 nM. It selectively degrades CRBN without affecting neo-substrates IKZF1 and IKZF3. -
USP7 PROTAC Degrader
U7D-1 is a first-in-class, potent, and selective PROTAC degrader of USP7 (ubiquitin-specific protease 7), with a DC₅₀ of 33 nM in RS4;11 cells. It exhibits anticancer activity and induces apoptosis in Jeko-1 cells, supporting its utility in cancer research targeting deubiquitinating enzymes. -
Cysteine Residues Modifier
N-Ethylmaleimide (NEM) is a potent chemical reagent that irreversibly alkylates free sulfhydryl groups, specifically targeting cysteine residues. This compound serves as an effective inhibitor of cysteine proteases and significantly affects phosphate transport in mitochondria. With an IC50 value of 6.3 μM, N-Ethylmaleimide is valuable for modifying cysteine residues in proteins and peptides, making it an essential tool in biochemical research and studies involving protein functionality and structure. -
RNF5 Degrader
RNF5-IN-1 is a selective RNF5 degrader that targets the RNF5 E3 ubiquitin ligase, inhibiting its activity and facilitating its proteasomal degradation via endoplasmic reticulum-associated degradation (ERAD). It demonstrates significant biological activity by inhibiting α-1-antitrypsin dislocation with an IC50 value of 2.7 μM. This compound is valuable for research into conditions such as cystic fibrosis, acute myeloid leukemia, and various viral infections.
