Caspase

Inhibitory Selectivity
Catalog No.Inhibitor Name Pan-CaspaseCaspase-1Caspase-2Caspase-3Caspase-4Caspase-5Caspase-6Caspase-7Caspase-8Caspase-9Caspase-10
A10984VX-765 (Belnacasan)
**
***
A12373Z-VAD-FMK
*
A13503Z-DEVD-FMK
A14915Q-VD-OPh hydrate
****
****
***
***
A14919Caspase-3/7 Inhibitor I
****
***
A12611Z-VEID-FMK
A12637Z-VDVAD-FMK
A12697Z-DQMD-FMK
A12800Z-IETD-FMK
A14358Z-LEHD-FMK
A14284Z-FA-FMK
A15300Ivachtin
****
A15392Boc-D-FMK
A14916Z-WEHD-FMK
A15816Ac-DEVD-CHO
***
*
****
**
**
**
***
****
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A10984 SALE

VX-765 (Belnacasan)

Caspase-1/4 inhibitor
VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
A12800

Z-IETD-FMK

caspase 8 inhibitor
Z-IETD-FMK is a specific inhibitor of caspase 8.
A12697

Z-DQMD-FMK

Caspase-3 inhibitor
Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.
A12637

Z-VDVAD-FMK

Caspase-2 inhibitor
Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes.
A12611

Z-VEID-FMK

Caspase-6 inhibitor
Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2.
A15816

Ac-DEVD-CHO

Caspase Inhibitor
Ac-DEVD-CHO is an aldehyde peptide and a CPP32/Apopain Inhibitor.
A15319

Ac-IEPD-AFC

Fluorogenic caspase substrate
Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.
A15308

PETCM

Caspase-3 activator
PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols.
A15300

Ivachtin

Caspase-3 inhibitor
Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
A15294

AZ 10417808

Caspase-3 inhibitor
AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM).
A15291

Ac-LEHD-AFC

Fluorogenic caspase substrate
Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
A12373 SALE

Z-VAD-FMK

Pan Caspase Inhibitor
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
A14100

Nivocasan (GS-9450)

Caspase inhibitor
Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
A13503 SALE

Z-DEVD-FMK

Caspase-3 Inhibitor
Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
A14358

Z-LEHD-FMK

Caspase-9 Inhibitor
Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.
A14915 SALE

Q-VD-OPh hydrate

Caspase inhibitor
Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
A14916

Z-WEHD-FMK

Caspase inhibitor
Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity.
A14919

Caspase-3/7 Inhibitor I

Caspase-3/7 Inhibitor
Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
A16340

Z-VAD(OH)-FMK

Caspase inhibitor
Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases.
A16317

Z-YVAD-FMK

Caspase-1 inhibitor
Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.
A15392

Boc-D-FMK

Caspase inhibitor
BOC-D-FMK is a Novel inhibitor of Caspase-3.
A13704

25-hydroxy Cholesterol

-
25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types
A14284

Z-FA-FMK

Irreversible Cysteine Protease inhibitor
Z-FA-FMK is an irreversible cysteine protease inhibitor.
A13070 SALE

LY573636 (Tasisulam)

Apoptosis inducer
LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
A11944

Apoptosis Activator 2

Apoptosis Activator
Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells
A11090 SALE

PAC-1

Caspase activator
PAC-1 is first procaspase activating compound.
A16381

Z-FA-FMK

Cysteine protease inhibitor
Z-FA-FMK is an irreversible inhibitor of cysteine protease

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