Catalog No.
Product Name
Application
Product Information
Citations
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Impurity of Asenapine
Asenapine impurity 1 is a recognized impurity of Asenapine, an atypical antipsychotic known for its antagonistic activity on serotonin, adrenoceptors, dopamine, and histamine receptors. With reported pKi values ranging from 8.2 to 10.5 across these targets, it is relevant for studies investigating the pharmacological profile of Asenapine. This impurity is important for quality control and characterization in research contexts focused on schizophrenia and bipolar disorder treatments. -
Drug Impurity
Brexpiprazole impurity 1 is a chemical impurity related to the atypical antipsychotic Brexpiprazole, which primarily targets serotonin and dopamine receptors. This impurity can be utilized in the assessment of drug quality and to investigate the stability and degradation pathways of Brexpiprazole. Its presence may influence the pharmacological profile and safety evaluations in related research applications. -
Drug Derivative
TA-993 is a drug derivative that enhances limb blood flow primarily through the modulation of the sympathetic nervous system, bypassing adrenergic receptors. This compound demonstrates a distinctive mechanism of action, potentially influencing heart rate through alternative pathways. TA-993 is valuable for research applications focused on understanding vascular dynamics and autonomic control in various physiological and pathological states. -
Active Molecule
WAY-271999 is an active molecule that serves as a potent antagonist of the cannabinoid receptor type 1 (CB1). It exhibits significant modulation of neuropsychiatric and metabolic processes, making it a valuable tool for research in obesity, addiction, and mood disorders. This compound is suitable for in vitro and in vivo studies aimed at elucidating the role of CB1 signaling in various physiological and pathological conditions. -
Drug Derivative
Benzoadenosine is a drug derivative that acts as an adenosine receptor modulator. It exhibits biological activities that may influence cellular signaling pathways involving adenosine, making it valuable for research in pharmacology and drug development. This compound can be utilized to investigate the role of adenosine-related mechanisms in various biological processes and disease states. -
Vasoconstrictor Agent
Nordefrin, a derivative of norepinephrine, functions primarily as a vasoconstrictor agent. It exerts its biological activity by stimulating adrenergic receptors, leading to increased vascular resistance and elevated blood pressure. This compound is commonly utilized in research investigations focused on cardiovascular physiology and pharmacology, particularly those exploring blood pressure regulation and vascular function. -
Platelet Aggregation Inhibitor
Ataprost is a potent platelet aggregation inhibitor that functions as an orally active analogue of Carboprostacyclin. This compound demonstrates 2.6 times greater efficacy than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Additionally, Ataprost has been shown to alleviate coronary spasm, making it relevant for research in cardiovascular diseases and platelet function studies. -
Guanfacine Derivative
Etiguanfacine is a derivative of Guanfacine that primarily targets alpha-2 adrenergic receptors. It exhibits potential for reducing gastrointestinal side effects commonly associated with Guanfacine, making it a valuable tool for research into improved therapeutic profiles. This compound can be utilized in studies involving hypertension and attention-deficit hyperactivity disorder (ADHD), as well as in evaluating receptor-mediated mechanisms in neuropharmacology. -
Drug Derivative
Fepradinol is a drug derivative that primarily acts as a selective modulator of adrenergic receptors. This compound exhibits significant biological activity in influencing cardiovascular responses and can be utilized in research focused on cardiovascular pharmacology. Its modulatory effects make it valuable for investigating the therapeutic potential in treating various cardiovascular disorders. -
Drug Derivative
Methoserpidine is a drug derivative that primarily functions as an antagonist of the alpha-adrenergic receptor. This compound exhibits significant biological activity in modulating cardiovascular responses and neurotransmitter release, making it useful for research in hypertension and other cardiovascular disorders. Its properties enable exploration of adrenergic signaling pathways and may provide insights into potential therapeutic strategies. -
Dexoxadrol Enantiomer
Levoxadrol is the active enantiomer of dexoxadrol, primarily targeting adrenergic receptors. This compound exhibits potent agonistic activity, making it valuable for research applications in cardiovascular and neuropharmacology studies. Its distinct biological properties facilitate investigations into adrenergic signaling pathways and their role in various physiological and pathological conditions. -
Cannabinoid Compound
Δ8-THCO (delta 8-tetrahydrocannabinol) is a cannabinoid compound derived from Cannabis sativa. This compound exhibits psychoactive properties akin to delta-9-THC, engaging with the CB1 cannabinoid receptor, which is implicated in various physiological processes such as appetite, pain sensation, and mood regulation. Δ8-THCO is utilized in research focused on understanding the effects of cannabinoids on the endocannabinoid system and exploring potential therapeutic applications in pain management and anxiety treatment. -
Peptide
Cionin is a disulfotyrosyl hybrid peptide derived from cholecystokinin and gastrin. It primarily targets cholecystokinin receptors, mediating various physiological functions such as gastric motility and enzyme secretion. This compound is utilized in research applications examining gastrointestinal physiology and the endocrine system. Its unique structure allows for the exploration of receptor interactions and signaling pathways in peptide studies. -
Nasal Vasoconstrictor
Tymazoline hydrochloride is an imidazoline derivative known for its nasal vasoconstrictor properties. It acts primarily on alpha-adrenergic receptors, leading to the reduction of nasal mucosal edema. This compound is valuable in research applications related to rhinitis and other conditions involving nasal congestion. -
Drug Derivative
MRS 2500 is a potent drug derivative that selectively targets adenosine A3 receptors. This compound exhibits significant effects on cellular signaling pathways, making it valuable for research involving inflammation and cancer biology. MRS 2500 can be utilized in studies aimed at understanding the role of adenosine receptors in various physiological and pathological processes. -
Alkaloid
N-(2-Hydroxy-3-methylbutyl)-adenosine is a natural alkaloid that modulates adenosine receptors. Its biological activity includes influencing various cellular processes such as inflammation and neuroprotection. This compound is utilized in research exploring adenosine signaling pathways and its implications in physiological and pathological conditions. -
Exenatide Impurity
(D-Asp28)-Exenatide is an impurity of Exenatide, which functions as a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. This compound plays a significant role in the regulation of glucose homeostasis and appetite control, making it relevant for research in diabetes and obesity. The characterization of this impurity is essential for understanding the pharmacological properties and ensuring the quality of Exenatide in therapeutic applications. -
Pressor/Sympathomimetic Agent
Gepefrine is an orally active sympathomimetic agent with pressor properties. It primarily targets adrenergic receptors, enhancing vascular response and improving arterial pressure regulation. Gepefrine is utilized in research to study its effects on orthostatic dysregulation and cardiovascular dynamics. -
Stable Isotope
3-O-Methyl Colterol-d9 is a deuterium-labeled analog of 3-O-Methyl Colterol. This stable isotope is utilized in analytical studies to track metabolic pathways and quantify interactions in biological systems. Its primary applications include pharmacokinetic studies and the investigation of drug metabolism, enhancing the understanding of biological processes involving beta-adrenergic receptors. -
LAI Antipsychotic
Aripiprazole Lauroxil is a long-acting injectable antipsychotic targeting dopamine receptors D2 and D4. It is an N-acyloxymethyl proagent of Aripiprazole, which undergoes enzymatic cleavage by esterases in the body to yield N-hydroxymethyl aripiprazole and lauric acid, further converting to aripiprazole and formaldehyde. This compound exhibits therapeutic activity in the management of schizophrenia and is utilized in research related to psychotropic medications and long-term treatment strategies. -
GLP-1R Agonist
GLP-1R Agonist 3 is a potent agonist of the glucagon-like peptide-1 receptor (GLP-1R). This compound, a modified imidazole derivative, plays a significant role in modulating insulin secretion and glucose homeostasis. GLP-1R Agonist 3 is primarily utilized in research focused on diabetes and metabolic disorders, offering avenues for developing novel therapeutic strategies. -
Antipsychotic Agent
Carphenazine is a phenothiazine antipsychotic agent that primarily targets dopamine receptors in the central nervous system. It exhibits significant antipsychotic activity, making it useful for studying the mechanisms underlying chronic schizophrenic psychoses. This compound is employed in research to better understand therapeutic interventions for various psychotic disorders. -
Platelet Aggregation Inhibitor
Cloricromen hydrochloride is a potent platelet aggregation inhibitor that effectively targets and modulates platelet activation pathways. This compound has demonstrated the ability to inhibit platelet aggregation in both human and experimental thrombosis models, making it a valuable reagent for research into cardiovascular diseases and thrombotic disorders. Cloricromen hydrochloride is suitable for studies focused on the mechanisms of platelet function and the development of antithrombotic therapies. -
CGRP Antagonist
SB 268262 is a selective antagonist of the calcitonin gene-related peptide (CGRP) receptor. This compound exhibits high affinity for CGRP receptors in the human brain, making it a valuable tool for studying CGRP signaling pathways. SB 268262 is applicable in research investigating the pharmacological properties of non-peptide CGRP receptor antagonists, also known as gepants, in models including rat, pig, and human meninges. -
Platelet Aggregation Inhibitor
KP-10614 is a potent, orally active inhibitor of platelet aggregation, primarily targeting ADP-induced aggregation with an IC50 of 1 nM. This compound exhibits dose-dependent inhibition of ex vivo platelet aggregation in rat models. KP-10614 demonstrates significant antithrombotic effects across various thrombosis models, making it a valuable tool for research into thrombotic diseases. -
Stable Isotope
N-Pentylindole-d11 is a deuterated analogue of 1-Pentyl-1H-indole, serving as a stable isotope. This compound is particularly valuable in pharmacokinetic studies, as it aids in tracing the metabolic pathways of indole-based compounds. Its application extends to the analysis of drug metabolism and the study of cannabinoid receptors, enhancing the understanding of biological mechanisms in related research fields. -
Stable Isotope
1-Oxo Colterol-d9 is a deuterium-labeled analog of 2-(Tert-butylamino)-1-(3,4-dihydroxyphenyl)ethan-1-one, serving as a stable isotope standard. This compound is valuable for quantitative mass spectrometry applications in biochemical research, particularly in studies involving adrenergic receptor signaling and pharmacokinetics. Its incorporation of deuterium enables precise tracking and analysis of metabolic pathways, enhancing the understanding of drug metabolism and activity. -
Stable Isotope
5'-Hydroxyphenyl carvedilol-d5 is a stable isotope-labeled analogue of carvedilol, targeting beta-adrenergic receptors. This deuterated compound is useful in pharmacokinetic studies, enabling the tracing of metabolic pathways and the assessment of drug disposition in various biological systems. Its structural modifications enhance the sensitivity and accuracy of analytical methods, making it an essential reagent for research applications in cardiovascular pharmacology and drug development. -
Stable Isotope
rac-Rotigotine-d3 methyl ether is a deuterium-labeled analogue of the dopamine agonist rotigotine, targeting dopamine D2 and D3 receptors. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research, enabling precise tracking of rotigotine's distribution and metabolism in biological systems. Its application enhances the understanding of dopamine receptor activity and drug interactions. -
Adrenergic Receptor Antagonist
Yohimbine-d3 is a deuterated derivative of Yohimbine, functioning as an adrenergic receptor antagonist. This compound is utilized in research to study the modulation of adrenergic signaling pathways, specifically the alpha-2 adrenergic receptors. Its applications include investigations into the effects of adrenergic blockade on physiological processes and the potential therapeutic roles in conditions such as depression and sexual dysfunction. -
Stable Isotope
Dexmedetomidine-d4 L-tartrate (-d4-major) is a deuterium-labeled derivative of Dexmedetomidine L-tartrate, serving as a stable isotope for research applications. This compound is primarily utilized in pharmacokinetic studies and metabolic labeling, enabling accurate tracking of drug disposition and action mechanisms. It supports investigations into alpha-2 adrenergic receptor modulation and sedation research, providing insights into the pharmacological properties of its parent compound. -
Stable Isotope
1H-1-Ethyl-d5 Candesartan is a deuterium-labeled derivative of 1H-1-Ethyl Candesartan, primarily utilized as a stable isotope. This compound is valuable in pharmacokinetic studies, allowing for precise tracking of drug metabolism and distribution. It aids researchers in understanding the metabolic pathways and interactions of angiotensin receptor antagonists in cardiovascular studies. -
Stable Isotope
(R)-(+)-Celiprolol-d9 hydrochloride is a deuterium-labeled analogue of the racemic beta-blocker Celiprolol, primarily targeting beta-adrenergic receptors. This stable isotope derivative facilitates precise pharmacokinetic studies and isotopic labeling experiments in chemical research. Its unique properties make it suitable for applications in metabolomics, drug metabolism, and tracer studies to elucidate the pharmacodynamics of beta-blockers. -
Stable Isotope
(Rac)-Ambrisentan-d5 is a deuterium-labeled form of (Rac)-Ambrisentan, functioning primarily as a selective endothelin receptor antagonist. Its key biological activity includes inhibition of endothelin-1, a peptide known to play a crucial role in vasoconstriction and blood pressure regulation. This stable isotope is particularly useful in pharmacokinetic studies, allowing for precise tracking of drug metabolism and distribution in biological systems. -
Stable Isotope
Apomorphine hydrochloride-d4 is a deuterium-labeled derivative of Apomorphine hydrochloride, designed as a stable isotope for metabolic studies. This compound serves as a valuable tool in pharmacokinetic and drug metabolism research, enabling precise tracking of Apomorphine in biological systems. Its application extends to studies on dopamine receptor modulation and related neurological pathways, facilitating a deeper understanding of dopaminergic signaling and its implications in various disorders. -
Stable Isotope
trans-Dihydro Tetrabenazine-d7 is a deuterium-labeled stable isotope of (2S,3S,11bS)-3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol. It serves as a valuable tool for isotopic labeling in biochemical research. Its distinct mass characteristics facilitate studies on pharmacokinetics, metabolism, and drug interactions, particularly in the context of neuropharmacology and the investigation of dopamine receptors. -
Stable Isotope
Labetalol hydrochloride-d5 is a deuterium-labeled form of Labetalol hydrochloride, specifically designed as a stable isotope for research applications. This compound functions as a selective α1-adrenergic and non-selective β-adrenergic receptor antagonist, primarily utilized for its antihypertensive properties. It is suitable for studying cardiovascular conditions, including hypertension, especially in contexts such as pregnancy where blood pressure regulation is critical. The stable isotope labeling facilitates advanced pharmacokinetic and metabolic studies. -
Drug Impurity
Ropinirole impurity 3 is a characterized impurity associated with the dopamine receptor agonist Ropinirole. This compound is crucial for assessing the purity and quality of Ropinirole in pharmaceutical formulations. It aids in the development and validation of analytical methods required for regulatory compliance in drug manufacturing. -
Drug Impurity
Tamsulosin impurity 14 is a known impurity associated with the pharmaceutical compound Tamsulosin, primarily targeting alpha-1 adrenergic receptors. This impurity is significant for quality control and analytical studies in drug development, particularly in determining the purity and stability of Tamsulosin formulations. Its characterization is essential for compliance with pharmaceutical regulations and ensuring therapeutic efficacy. -
Drug Impurity
Fluphenazine decanoate impurity 8 is a known impurity associated with Fluphenazine decanoate, an antipsychotic medication primarily targeting dopamine receptors. This compound can be utilized in analytical research to evaluate the purity of pharmaceutical formulations and support drug development processes. Its presence may affect pharmacokinetics and pharmacodynamics, making it essential for quality control and safety assessments in therapeutic applications. -
Drug Impurity
Mirabegron impurity 4 is a chemical impurity associated with the drug Mirabegron, a beta-3 adrenergic receptor agonist. This impurity is important for assessing the purity and quality of Mirabegron formulations in pharmaceutical research. Its characterization is crucial for ensuring compliance with regulatory standards and for conducting stability studies in drug development. -
Racemate
(±)-Levomepromazine is a racemic mixture primarily targeting dopamine receptors. It exhibits notable antipsychotic activity, making it relevant for research in psychiatry and neuropharmacology. Its effects on neurotransmitter pathways are valuable for studying various psychiatric disorders and the mechanisms of psychotropic agents. -
H1 Receptor Antagonist
(R)-Promethazine is an H1 receptor antagonist, serving as the R-enantiomer of Promethazine. This compound exhibits potent antihistamine activity, primarily used for its sedative effects. Additionally, it demonstrates weak antipsychotic properties, making it useful in various research applications related to sleep disorders and psychotropic effects. -
Nantenine Isomer
(R)-Nantenine is the levorotatory isomer of Nantenine, with a high affinity and selectivity for the α1A adrenergic receptor. This compound effectively blocks the behavioral suppression associated with 3,4-methylenedioxymethamphetamine (MDMA). Research applications for (R)-Nantenine primarily involve the study of disorders linked to MDMA abuse, providing valuable insights into its neuropharmacological effects. -
Isomer of 5-Fluoro PB-22
5-Fluoro PB-22 6-hydroxyisoquinoline isomer is a structural isomer of the synthetic cannabinoid 5-Fluoro PB-22, acting primarily as a cannabinoid receptor agonist. This compound exhibits significant binding affinity for CB1 and CB2 receptors, contributing to its potential biological effects. It can be utilized in research applications aimed at investigating the biochemical pathways and pharmacological effects of synthetic cannabinoids. -
Isomer of 5-Fluoro PB-22
5-Fluoro PB-22 N-(3-fluoropentyl) isomer is a structural isomer of 5-Fluoro PB-22, targeting the cannabinoid receptors. This compound exhibits significant biological activity related to the modulation of cannabinoid receptor signaling pathways. It is primarily utilized in research applications exploring cannabinoid pharmacology, drug interaction studies, and the development of therapeutic agents targeting the endocannabinoid system. -
Isomer of 5-Fluoro PB-22
5-Fluoro PB-22 5-hydroxyisoquinoline isomer is a structural isomer of 5-Fluoro PB-22, targeting the cannabinoid receptors. This compound has been studied for its potential biological activities within the endocannabinoid system. It may be utilized in research related to neuropharmacology and the exploration of cannabinoid receptor modulation. -
Isomer of PB-22
PB-22 6-Hydroxyquinoline isomer is a structural isomer of the cannabinoid PB-22, which primarily acts on the cannabinoid receptors. This compound may exhibit similar biological activities related to modulation of the endocannabinoid system, potentially influencing pain, inflammation, and mood regulation. It is suitable for research applications in pharmacology, toxicology, and cannabinoid receptor studies. -
Isomer of PB-22
PB-22 7-Hydroxyquinoline isomer is a structural isomer of PB-22, a synthetic cannabinoid. This compound targets cannabinoid receptors and exhibits activity that may influence the endocannabinoid system. PB-22 7-Hydroxyquinoline isomer is primarily utilized in cannabinoid research to explore its pharmacological properties and potential therapeutic applications. -
Isomer of PB-22
PB-22 8-Hydroxyisoquinoline isomer is a structural isomer of the synthetic cannabinoid PB-22. This compound acts primarily on cannabinoid receptors, modulating various signaling pathways. Its unique structure may offer insights into cannabinoid research and the development of novel therapeutic agents targeting the endocannabinoid system. PB-22 8-Hydroxyisoquinoline isomer is suitable for biochemical assays and pharmacological studies exploring cannabinoid receptor interactions.
