Catalog No.
Product Name
Application
Product Information
Citations
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Adrenergic Receptor Agonist
Tizanidine hydrochloride is a selective α2-adrenoceptor agonist that serves as an effective skeletal muscle relaxant. It primarily promotes muscle relaxation by reducing the presynaptic release of excitatory amino acids, such as glutamate and aspartate, within spinal cord interneurons. In addition to its central effects, Tizanidine hydrochloride demonstrates potential anti-cancer properties by inhibiting lung cancer cell proliferation, migration, and invasion, while promoting apoptosis via the modulation of the AKT and Wnt3a/β-catenin signaling pathways. This compound is clinically relevant for the management of spasticity associated with conditions like multiple sclerosis, stroke, and spinal cord injury. -
Neurotransmitter
Histamine is a biogenic amine that acts as an agonist for histamine receptors, playing a significant role as a neurotransmitter. It is involved in local immune responses and the regulation of various physiological functions, including vasodilation. Histamine influences the p38 MAPK/Akt signaling pathway and demonstrates notable antitumor, antioxidant, and anti-inflammatory properties. It is commonly utilized in research related to acute myeloid leukemia, malignant melanoma, and renal cell carcinoma. -
Adrenergic Receptor Agonist
Tizanidine is a selective α2-adrenoceptor agonist that functions primarily as a skeletal muscle relaxant. It exerts muscle relaxation effects by inhibiting the release of excitatory amino acids, thereby modulating synaptic activity in the spinal cord. Additionally, Tizanidine demonstrates anti-cancer properties by inhibiting proliferation, migration, and invasion of lung cancer cells, as well as inducing apoptosis through the upregulation of Nischarin and suppression of the AKT and Wnt3a/β-catenin pathways. This compound is utilized clinically for the management of spasticity associated with conditions such as multiple sclerosis, stroke, and spinal cord injury. -
Stable Isotope
Histamine-d4 is a deuterium-labeled derivative of histamine, functioning primarily as a stable isotope for metabolic and pharmacokinetic studies. This compound acts as an agonist at histamine receptors and serves as a notable vasodilator, playing a critical role in local immune responses, intestinal physiological regulation, and neurotransmission. Histamine influences several signaling pathways, including p38 MAPK and Akt, and exhibits diverse biological activities such as anti-inflammatory, antioxidant, and potential antitumor effects. Its applications in research extend to the study of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma, facilitating a deeper understanding of these conditions. -
5-HT5A Receptor Antagonist
SB-699551 free base is a selective antagonist of the 5-HT5A receptor, characterized by a pKi of 8.2 nM, which allows for effective brain penetration. It exhibits significant selectivity over various serotonin receptor subtypes, dopamine receptors, and the α1B adrenoceptor. This compound disrupts Gαi/o-coupled and PI3K/AKT/mTOR signaling pathways, influencing the phosphorylation of key proteins such as CREB, ATF1, AKT, PRAS40, S6K, and FOXO1 in breast tumor cells. SB-699551 free base is valuable for research into anxiety, breast cancer, and Alzheimer's disease. -
Stable Isotope
Histamine-13C5 is a stable isotope-labeled form of histamine, primarily functioning as an agonist for histamine receptors. This organic nitrogen compound plays a critical role in local immune responses, modulates intestinal physiological functions, and acts as a neurotransmitter. Histamine influences the p38 MAPK/Akt signaling pathway and demonstrates antitumor, antioxidant, and anti-inflammatory properties. Research applications of Histamine-13C5 include the investigation of conditions such as acute myeloid leukemia, malignant melanoma, and renal cell carcinoma, facilitating deeper insights into these diseases. -
Anti-CXCR4 Antibody
LY-2624587 is a humanized IgG4 monoclonal antibody that antagonizes CXCR4. By blocking the interaction between SDF-1 and CXCR4, it inhibits SDF-1-induced GTP binding, significantly reducing cell migration and promoting apoptosis in human lymphoma and leukemia cells. Additionally, LY-2624587 impedes CXCR4 and SDF-1-mediated signaling pathways, including the activation of MAPK and AKT. This reagent is valuable for research applications involving human hematological malignancies, particularly acute myeloid leukemia (AML). -
CXCR4 Antagonist.
BPRCX807 is a selective and potent antagonist of the CXC chemokine receptor type 4 (CXCR4). It effectively inhibits CXCL12-mediated phosphorylation of ERK and Akt, leading to significant suppression of primary tumor growth. This compound is applicable for research in hepatocellular carcinoma, providing insights into its therapeutic potential in cancer treatment. -
GLP-1R Agonist
Pegloxenatide is a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist. It exhibits various biological activities, including the reduction of blood glucose and lipids, weight management, anti-inflammatory effects, and promotion of wound healing, as well as providing protective effects on liver and heart tissues. Pegloxenatide is primarily utilized in research focused on type 2 diabetes and its associated complications. -
S1PR Regulator
Mocravimod is a sphingosine-1-phosphate receptor (S1PR) modulator that inhibits the signaling necessary for T cell egress from lymph nodes and other lymphoid tissues. It preferentially binds to S1PR1, exhibiting beneficial effects such as a reduction in reactive oxygen species (ROS) levels, prevention of mitochondrial permeability transition pore opening, and enhancement of mitochondrial membrane potential (MMP). Additionally, Mocravimod promotes the phosphorylation of key signaling proteins including AKT, ERK, GSK-3β, JAK2, and STAT3, while preserving T cell effector function. This reagent is suitable for research into acute myelogenous leukemia, diabetes, and myocardial ischemia-reperfusion injury. -
CXCR4 Inhibitor
Hit 14 is a selective inhibitor of C-X-C chemokine receptor type 4 (CXCR4), demonstrating an IC50 value of 254 nM. This compound effectively inhibits the migration and invasion of MDA-MB-231 cells, highlighting its potential in cancer research. Furthermore, Hit 14 modulates Akt phosphorylation and exhibits anti-inflammatory properties, demonstrating efficacy in reducing ear swelling and damage in mouse models. Its diverse biological activities make it a valuable tool for studies related to cancer metastasis and inflammation. -
α/β-Adrenergic Agonist
Etilefrine is an α/β-adrenergic agonist primarily targeting α1 and β1 receptors. Its activity induces vasoconstriction by stimulating α1 receptors, leading to increased peripheral resistance, while β1 receptor activation enhances myocardial contractility and elevates heart rate, resulting in improved blood pressure and cardiac output. Additionally, Etilefrine modulates the AMPK/Akt signaling pathway, influencing phosphorylation levels. This compound is applicable in cardiovascular research, notably in studies related to postural hypotension, chylothorax, and conditions characterized by low cardiac output. -
Anticancer Agent
Auriculasin is an anticancer agent that primarily targets VEGFR2, PI3K/AKT/mTOR, and MAPK signaling pathways. It effectively inhibits cell proliferation, induces apoptosis, and suppresses angiogenesis, while also promoting mitochondrial oxidative stress and ferroptosis. Additionally, Auriculasin demonstrates activity at the cannabinoid receptor CB1 with an IC50 of 8.92 μM. This compound is valuable for cancer research, particularly in studying prostate cancer, non-small cell lung cancer, and the development of anti-angiogenic therapies. -
Indole Alkaloid
Tetrahydroalstonine is an indole alkaloid that acts as a selective antagonist of the α₂-adrenergic receptor. This compound demonstrates neuroprotective effects and has been shown to modulate autophagy-lysosomal function through the activation of the Akt/mTOR signaling pathway. Additionally, Tetrahydroalstonine significantly mitigates injury to primary cortical neurons induced by oxygen-glucose deprivation/reperfusion, making it a valuable tool for research into neuroprotection and cellular stress responses. -
α/β-Adrenergic Agonist
Etilefrine hydrochloride is an α/β-adrenergic agonist that selectively activates α1 and β1 adrenergic receptors. By stimulating α1 receptors, it induces vascular smooth muscle contraction, thereby increasing peripheral resistance and blood pressure. Additionally, activation of β1 receptors enhances myocardial contractility and heart rate, improving cardiac output. Etilefrine hydrochloride is valuable for cardiovascular research, particularly in studies related to postural hypotension, chylothorax, and the management of low cardiac output conditions. -
Bombesin Receptor Antagonist
Kuwanon G is a flavonoid compound that acts as an antagonist of the bombesin receptor. It demonstrates significant biological activities, including bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits potent antibacterial activity against oral pathogens, particularly cariogenic and periodontal bacteria. Additionally, it induces apoptosis while inhibiting the proliferation, migration, and invasion of tumor cells, making it valuable for research in gastric cancer and atherosclerosis. -
Amino Acid Polypeptide Hormone Analogue
Sincalide ammonium is an amino acid polypeptide hormone analogue of cholecystokinin (CCK) that primarily targets gallbladder function. It is utilized in clinical settings for its ability to promote gallbladder contraction, thus facilitating the diagnosis of gallbladder and pancreatic disorders. By increasing bile secretion and causing the contraction of the gallbladder while relaxing the sphincter of Oddi, Sincalide ammonium aids in the efficient drainage of bile into the duodenum, making it a valuable tool in postevacuation cholecystography. -
Angiotensin Receptor Inhibitor
YS-49 monohydrate is a selective angiotensin receptor inhibitor, primarily targeting the angiotensin II pathway. This compound effectively reduces angiotensin II-stimulated proliferation of vascular smooth muscle cells by inducing heme oxygenase-1, offering potential therapeutic insights for cardiovascular research. Additionally, as an isoquinoline alkaloid, YS-49 demonstrates significant positive inotropic effects through the activation of cardiac β-adrenoceptors, making it a valuable reagent for studies involving cardiac function and vascular biology. -
CB1/P-gp Inhibitor
Voacamine is an indole alkaloid that acts as an antagonist of the cannabinoid receptor 1 (CB1) and also functions as a P-glycoprotein (P-gp) inhibitor. This compound enhances the efficacy of Doxorubicin by modulating P-gp activity, promoting apoptosis-independent autophagic cell death in human osteosarcoma cells. Additionally, Voacamine activates mitochondrial-associated apoptosis signaling pathways while inhibiting the PI3K/Akt/mTOR pathway, thus suppressing breast cancer progression. Moreover, it demonstrates oncogenic activity against colorectal cancer by inhibiting epidermal growth factor receptor (EGFR). -
S1P1 Agonist
SEW2871 is a potent and highly selective agonist of the sphingosine-1-phosphate type 1 receptor (S1P1), exhibiting an EC50 of 13.8 nM. This compound activates critical signaling pathways, including ERK, Akt, and Rac, and facilitates S1P1 internalization and recycling. SEW2871 effectively reduces lymphocyte populations in the bloodstream and shows promise for the study of various conditions, such as diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses. -
5-HT5A Antagonist
SB-699551 is a selective 5-HT5A receptor antagonist with a pKi of 8.2 nM, demonstrating significant brain penetrance. This compound exhibits high selectivity over various 5-HT receptor subtypes, dopamine receptors, and α1B adrenoceptors. By disrupting Gαi/o-coupled signaling and the PI3K/AKT/mTOR pathways, SB-699551 influences phosphorylation of key proteins such as CREB, ATF1, AKT, PRAS40, S6K, and FOXO1 in breast tumor cells. It serves as a valuable tool in the study of anxiety, breast cancer, and Alzheimer's disease. -
Artificial Insulin
Insulin Detemir is an artificial insulin that regulates blood glucose levels by mimicking the effects of natural insulin. It activates the secretion of GLP-1 through enhanced expression of Gcg, utilizing signaling pathways involving Akt and extracellular signal-regulated kinase (ERK) alongside CREB. This reagent is primarily used in research related to type 2 diabetes, facilitating studies on glucose metabolism and insulin sensitivity. -
Dopamine β-hydroxylase Inhibitor
Fusaric acid is a potent dopamine β-hydroxylase inhibitor that reduces endogenous levels of norepinephrine and epinephrine in various tissues, including the brain, heart, spleen, and adrenal glands. By inducing oxidative stress and apoptosis, fusaric acid disrupts mitochondrial integrity and activates key apoptosis-related proteases such as Caspase-3/7, -8, and -9. Additionally, fusaric acid regulates pivotal apoptotic proteins, inhibits fibrosis-related signaling pathways including NF-κB and TGF-β1/SMADs, and mitigates collagen deposition. Its applications extend to myocardial fibrosis and cardiac hypertrophy research, as well as studies on esophageal and liver cancers. -
Stable Isotope
Theophylline-d3 is a deuterated form of theophylline, primarily used as a stable isotope in research applications. Theophylline functions as a potent phosphodiesterase inhibitor and adenosine receptor antagonist, contributing to its ability to relax airway smooth muscle. Additionally, it demonstrates anti-inflammatory effects by enhancing IL-10 production and inhibiting NF-κB nuclear translocation. This compound is valuable for studying asthma and chronic obstructive pulmonary disease (COPD) mechanisms and therapies. -
CB2 Agonists
MN-25 is an orally active indolpyridone that functions as a selective CB2 agonist, exhibiting a Ki of 245 nM for CB1 and a potent 11 nM for CB2. This compound demonstrates significant anti-inflammatory properties by inhibiting TNF-R release in human peripheral blood mononuclear cells in vitro, with an IC50 of 33 μM. In vivo studies have shown that MN-25 is effective in reducing acute inflammation in a mouse model at oral doses up to 50 mg/kg, making it a valuable reagent for exploring cannabinoid receptor biology and therapeutic applications in inflammation. -
Stable Isotope
Theophylline-13C2,d6 is a stable isotope-labeled form of Theophylline (1,3-Dimethylxanthine), primarily acting as a phosphodiesterase (PDE) inhibitor and adenosine receptor antagonist. This reagent enhances anti-inflammatory responses by increasing IL-10 levels and inhibiting NF-κB nuclear translocation, while also promoting apoptosis. It serves as a valuable tool for research into airway smooth muscle relaxation and the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). -
α-Adrenergic Receptor Agonist
Naphazoline is a potent α-adrenergic receptor agonist that exerts its biological activity through vasoconstriction and the reduction of vascular hyperpermeability. It effectively diminishes the levels of inflammatory mediators, including TNF-α, IL-1β, IL-6, IFN-γ, IL-4, as well as IgE, GMCSF, and NGF. Naphazoline is widely utilized in research related to non-bacterial conjunctivitis and other conditions involving inflammation and vascular function. -
IBAT Inhibitor
(S)-Elobixibat is a selective inhibitor of the intestinal bile acid transporter (IBAT). It effectively lowers LDL cholesterol levels, enhances serum levels of GLP-1, and promotes colonic motility, making it a valuable tool in metabolic syndrome research. This compound is utilized in studies related to constipation, dyslipidemia, non-alcoholic fatty liver disease, and liver tumors. -
CB2 Agonist
GW405833 hydrochloride is a selective agonist of the cannabinoid receptor 2 (CB2) with potent activity, characterized by EC50 and Ki values of 0.65 nM and 3.92 nM, respectively. In addition to its action as a CB2 agonist, GW405833 also acts as a non-competitive antagonist at the CB1 receptor, influencing analgesic pathways. This compound has been shown to significantly inhibit cAMP production stimulated by Forskolin and to down-regulate HIF-1α, which contributes to its potential role in alleviating acute liver failure. GW405833 hydrochloride is valuable for research related to pain management and metabolic disorders. -
α-Adrenergic Receptor Agonist
Naphazoline nitrate is an α-adrenergic receptor agonist that effectively induces vasoconstriction and reduces vascular hyperpermeability. It has been shown to lower the levels of inflammatory mediators such as TNF-α, IL-1β, IL-6, as well as cytokines including IFN-γ and IL-4. Naphazoline nitrate is utilized in research related to non-bacterial conjunctivitis, providing insight into its effects on inflammation and vascular response. -
CB2 Agonist
GW-405833 is a selective agonist of the cannabinoid receptor 2 (CB2), with an EC50 value of 0.65 nM. It exhibits a strong affinity for CB2, while displaying significantly lower activity at CB1, with EC50 and Ki values of 16.1 μM and 4772 nM, respectively. In addition to its agonistic effects at CB2, GW-405833 acts as a non-competitive antagonist at CB1, mediating analgesic and anti-inflammatory effects. Furthermore, it inhibits forskolin-stimulated cAMP production and down-regulates HIF-1α, potentially alleviating acute liver failure through modulation of glycolysis. This compound is useful for research in pain management, inflammation, and liver pathology. -
Dopamine D2/D3 Agonist
Piribedil is a potent and orally active agonist of dopamine D2 and D3 receptors, also exhibiting antagonistic activity at α2-adrenoceptors. Additionally, Piribedil inhibits MLL1 methyltransferase with an EC50 value of 0.18 μM. This compound is primarily utilized in research focused on Parkinson’s disease, circulatory disorders, and certain cancers, making it a valuable tool for exploring dopaminergic pathways and related therapeutic strategies. -
A2AAR/HDAC Dual Inhibitor
A2AAR/HDAC-IN-2 is a potent dual inhibitor targeting the adenosine A2A receptor (A2AAR) and histone deacetylase 1 (HDAC1). It demonstrates a strong binding affinity for A2AAR with a Ki value of 10.3 nM and exhibits significant inhibitory activity against HDAC1 with an IC50 of 18.5 nM. This compound is applicable in cancer research, particularly in studies exploring antitumor mechanisms and therapeutic efficacy. -
A2AAR/HDAC Inhibitor
A2AAR/HDAC-IN-1 is a potent dual inhibitor targeting the A2A adenosine receptor (A2AAR) and histone deacetylase 1 (HDAC1), with a Ki of 163.5 nM for A2AAR and an IC50 of 145.3 nM for HDAC1. This compound demonstrates significant anticancer activity, making it a valuable reagent for research in cancer therapeutics and epigenetic modulation. Its oral bioavailability enhances its utility in in vivo studies, facilitating investigations into the mechanisms underlying tumor growth and proliferation. -
A2A Receptor/HDAC Inhibitor
IHCH-3064 is a dual-target compound that inhibits the Adenosine A2A Receptor and histone deacetylase (HDAC). It demonstrates potent binding affinity for the A2A receptor (Ki = 2.2 nM) and selectively inhibits HDAC1 with an IC50 of 80.2 nM. This compound exhibits significant antiproliferative activity against various tumor cell lines in vitro, making it a valuable tool for tumor immunotherapy research applications. -
Dopamine D2/D3 Agonist
Piribedil maleate is a potent agonist of dopamine D2 and D3 receptors, with additional activity as an α2-adrenoceptor antagonist. It has been shown to inhibit MLL1 methyltransferase activity with an EC50 of 0.18 μM. Piribedil maleate is of interest for research applications related to Parkinson’s disease, circulatory disorders, and various cancers. -
Dopamine D2/D3 Agonist
Piribedil hydrochloride is a potent agonist of dopamine D2 and D3 receptors, serving as a valuable tool for investigating dopaminergic signaling pathways. In addition to its agonistic activity, it acts as an antagonist at α2-adrenoceptors and inhibits MLL1 methyltransferase with an EC50 of 0.18 μM. This compound is primarily utilized in research related to Parkinson's disease, circulatory disorders, and certain types of cancer, making it an important reagent for studies focused on neurodegeneration and tumor biology. -
Dopamine D2/D3 Agonist
Piribedil dihydrochloride is a potent dopamine D2 and D3 agonist, also functioning as an antagonist at α2-adrenoceptors. This compound exhibits inhibitory activity on MLL1 methyltransferase with an EC50 of 0.18 μM. It is primarily utilized in research focused on Parkinson's disease, circulatory disorders, and various types of cancers. -
Histamine N-Methyltransferase Inhibitor
SKF 91488 dihydrochloride is a potent, noncompetitive inhibitor of histamine N-methyltransferase, exhibiting a Ki value of 0.9 μM. This compound effectively blocks the metabolism of histamine, leading to elevated concentrations of histamine in biological systems. SKF 91488 dihydrochloride plays a significant role in research focusing on infection, inflammation, and cardiovascular diseases, including studies on Mycoplasma pneumonia and hemorrhagic hypotension. Its influence on blood pressure and bronchoconstriction further underscores its utility in exploring related pathophysiological mechanisms. -
Stable Isotope
Dopamine-d5 hydrochloride is a deuterium-labeled analogue of dopamine, a catecholamine neurotransmitter primarily synthesized in the substantia nigra, ventral tegmental area, and hypothalamus. This compound retains the essential biological functions of dopamine, including its interaction with D2 dopamine receptors, which mediates the endocytosis of VEGFR2, a key process in angiogenesis. Dopamine-d5 hydrochloride is valuable for research applications involving neurotransmitter dynamics, neuropharmacology, and angiogenic pathways. -
Antipsychotic Agent
Penfluridol is a potent, long-acting antipsychotic agent that primarily targets D2-like dopamine receptors. It exhibits significant anti-inflammatory properties by inhibiting TNFα-induced NF-κB activation and demonstrates efficacy in models of arthritis and colitis. Additionally, Penfluridol acts as a Ca2+-calmodulin inhibitor, inducing apoptosis and autophagy in various cellular contexts. This compound is utilized in research focusing on chronic schizophrenia, acute psychosis, Tourette syndrome, autoimmune diseases, and it also shows antibacterial activity against E. faecalis with a minimum inhibitory concentration of 7.81 μg/ml. -
Dopamine Receptor Antagonist
Perphenazine is a potent dopamine receptor antagonist, specifically targeting D2 and D3 receptors with Ki values of 0.56 nM and 0.43 nM, respectively, while also interacting with the 5-HT2A receptor and the Alpha-1A adrenergic receptor. This compound demonstrates inhibitory effects on cancer cell proliferation and promotes apoptosis. Perphenazine is valuable for research into psychiatric disorders, cancer biology, and inflammatory processes. -
H1 Receptor Antagonist
Pheniramine maleate is a first-generation histamine H1 receptor antagonist that primarily targets the central nervous system to produce sedative and hypnotic effects. In addition to its antihistaminic activity, Pheniramine maleate exhibits antitumor properties by inducing apoptosis in leukemia cells. It also demonstrates effectiveness as a local agent to alleviate pain and provide antipruritic effects in various applications. -
5-HT4 Agonist
Prucalopride succinate is a selective 5-HT4 receptor agonist known for its high affinity for human 5-HT4a and 4b receptors, with pKis of 8.6 and 8.1, respectively. This compound enhances intestinal motility and promotes regeneration of the enteric nervous system, making it relevant for research in chronic constipation and pseudo-intestinal obstruction. Additionally, Prucalopride succinate exhibits anticancer properties by inhibiting the PI3K/AKT/mTOR signaling pathway, thereby facilitating its application in cancer studies. -
Antibiotic
Adenoregulin, also known as Dermaseptin b2, is an antimicrobial peptide antibiotic that targets a broad spectrum of microorganisms. It exhibits activity against both Gram-negative and Gram-positive bacteria, as well as yeast and fungi. Additionally, Adenoregulin enhances the binding of agonists to the A1 adenosine receptor, making it valuable for research applications in microbiology and pharmacology. -
CXCR Inhibitor
Corydalmine, a CXCR inhibitor, demonstrates significant antifungal activity by inhibiting spore germination in various plant pathogenic and saprophytic fungi. Additionally, it serves as an oral analgesic agent, exhibiting potent analgesic effects. Corydalmine has been shown to alleviate Vincristine-induced neuropathic pain in murine models through the inhibition of the NF-κB-dependent CXCL1/CXCR2 signaling pathway, making it a valuable tool for pain research and therapeutic applications. -
CXCR Inhibitor
Corydalmine hydrochloride is a potent CXCR inhibitor that demonstrates significant biological activity by inhibiting spore germination in certain plant pathogenic and saprophytic fungi. Additionally, it exhibits notable analgesic properties, effectively alleviating Vincristine-induced neuropathic pain in murine models. This effect is mediated through the inhibition of the NF-κB-dependent CXCL1/CXCR2 signaling pathway, highlighting its potential applications in pain management research and fungal inhibition studies. -
Stable Isotope
Anandamide-d8 is a deuterated form of the endocannabinoid Anandamide, primarily known for its interaction with cannabinoid receptors CB1 and CB2. This compound modulates various neuronal and immune functions and can also engage additional receptors, including PPARs, TRPV1, and GPR18/GPR55. Anandamide-d8 exhibits potential anti-fungal and anti-inflammatory properties, making it valuable for research applications in fields such as neurodegenerative diseases, including Alzheimer's disease, and inflammatory conditions like ulcerative colitis. -
PARP-1 Inhibitor
Benzo[c][1,8]naphthyridin-6(5H)-one is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) and aurora kinase A, exhibiting IC50 values of 0.311 μM and 5.5 μM, respectively. This compound demonstrates low micromolar affinity for human adenosine receptors AR A1 and hA2A, with Ki values of 4.6 and 4.8 μM. Due to its mechanistic action, Benzo[c][1,8]naphthyridin-6(5H)-one is valuable for research applications targeting DNA repair pathways and cancer therapies. -
Histamine H2-Receptor Antagonist
Ranitidine hydrochloride is a selective histamine H2-receptor antagonist that effectively inhibits gastric secretion. It demonstrates significant antagonism of histamine-induced cardiac and uterine responses in isolated animal models, with pA2 values of 7.2 and 6.95, respectively. Additionally, ranitidine hydrochloride has been shown to inhibit the development and metastasis of breast tumors in murine models, indicating its potential utility in cancer research.
