Levodopa Conversion in Rat Jejunal Contents
Cell-based study · Luminal contents from the jejunum of wild-type Groningen rats (n = 5) [1]
Jejunal luminal contents from wild-type Groningen rats were incubated with L-DOPA. Chromatograms revealed that levodopa decarboxylation to dopamine coincided with the conversion of tyrosine to tyramine.
| Endpoint | Reported result | Reference |
|---|---|---|
| levodopa decarboxylation to dopamine | Reported result 1 mM levodopa; incubated for 24 h in an anaerobic chamber at 37 °C: Chromatograms revealed that levodopa decarboxylation to dopamine coincide with the conversion of tyrosine to tyramine. | [1] |
Literature-Reported Treatment Conditions
- Treatment concentration
- 1 mM
- Exposure duration
- incubated for 24 h in an anaerobic chamber at 37 °C
- Method
- suspended in EBB (5% w/v) containing 1 mM levodopa
- Vehicle
- EBB (5% w/v)
Methods and source locations
Compound reported in the paper: L-DOPA; Compound label in the paper: Levodopa
Literature evidence for the named compound in the stated model; no Adooq product-use or lot-performance claim.
Results > Upper small intestinal bacteria convert levodopa to dopamine (S2, S5); Methods > Incubation experiments of jejunal content (S126)
levodopa decarboxylation to dopamine: levodopa decarboxylation to dopamine; comparator: control samples — Results > Upper small intestinal bacteria convert levodopa to dopamine (S2); Methods > Incubation experiments of jejunal content (S126)