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Polygalacin D

Catalog No.: A30602
Apoptosis Inducer
Polygalacin D (PGD) is an apoptosis inducer derived from Platycodon grandiflorum, exhibiting significant anticancer and anti-proliferative effects. It effectively downregulates inhibitor of apoptosis (IAP) proteins, including survivin, cIAP-1, and cIAP-2, while inhibiting the PI3K/Akt signaling pathway through the dephosphorylation of GSK3β and Akt, along with reduced expression of PI3K. PGD serves as a valuable reagent for research in cancer biology and therapeutic investigations targeting apoptosis mechanisms.
Polygalacin D 66663-91-0 Apoptosis Inducer
Grouped product items
Size Price Stock Qty
1mg
$100.00
In stock
5mg
$295.00
In stock
10mg
$455.00
In stock
25mg
$740.00
In stock
50mg
$970.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPolygalacin D (PGD) is an apoptosis inducer derived from Platycodon grandiflorum, exhibiting significant anticancer and anti-proliferative effects. It effectively downregulates inhibitor of apoptosis (IAP) proteins, including survivin, cIAP-1, and cIAP-2, while inhibiting the PI3K/Akt signaling pathway through the dephosphorylation of GSK3β and Akt, along with reduced expression of PI3K. PGD serves as a valuable reagent for research in cancer biology and therapeutic investigations targeting apoptosis mechanisms.
Product Information
Catalog NumA30602
FormulaC57H92O27
Molecular Weight1209.32
CAS Number66663-91-0
SMILESO[C@H]([C@@H]([C@@H](O[C@@]1([H])[C@@H]([C@H]([C@H](O)CO1)O[C@@]2([H])[C@@H]([C@](CO)(O)CO2)O)O)[C@H](C)O3)O)[C@]3([H])O[C@H]([C@H]([C@@H](O)CO4)O)[C@@H]4OC([C@]56[C@](CC(C)(C)CC6)([H])C7=CC[C@@]([C@@]8([C@@]([C@](C)([C@@H](O[C@]9([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]9O)CO)[C@@H](O)C8)CO)([H])CC%10)C)([H])[C@]%10(C)[C@]7(C)C[C@H]5O)=O
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Apoptosis > Apoptosis Inducers