Dihydrorotenone is an irreversible inhibitor of mitochondrial complex I and serves as an apoptosis inducer. It demonstrates significant cytotoxicity to human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. Dihydrorotenone's insecticidal properties position it as a valuable tool in studies on neurodegenerative diseases, such as Parkinson's disease, as well as in safety assessments of natural pesticides and cancer chemoprevention research.
Dihydrorotenone is an irreversible inhibitor of mitochondrial complex I and serves as an apoptosis inducer. It demonstrates significant cytotoxicity to human plasma cells by triggering endoplasmic reticulum stress and activating the p38 signaling pathway. Dihydrorotenone's insecticidal properties position it as a valuable tool in studies on neurodegenerative diseases, such as Parkinson's disease, as well as in safety assessments of natural pesticides and cancer chemoprevention research.
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