EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) specifically designed to target the triple mutant EGFRL858R/T790M/C797S, exhibiting an IC50 of 18 nM. This compound effectively suppresses EGFR phosphorylation, thereby inducing apoptosis and causing cell cycle arrest at the G0/G1 phase. It serves as a valuable tool for research into cancer therapies focused on overcoming resistance in EGFR-mutated tumor cells.
EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) specifically designed to target the triple mutant EGFRL858R/T790M/C797S, exhibiting an IC50 of 18 nM. This compound effectively suppresses EGFR phosphorylation, thereby inducing apoptosis and causing cell cycle arrest at the G0/G1 phase. It serves as a valuable tool for research into cancer therapies focused on overcoming resistance in EGFR-mutated tumor cells.
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