(E/Z)-E64FC26 is a mixture of E-E64FC26 and Z-E64FC26, functioning as a potent pan-inhibitor of the protein disulfide isomerase (PDI) family. It exhibits significant biological activity with IC50 values of 1.9 μM for PDIA1, 20.9 μM for PDIA3, 25.9 μM for PDIA4, 16.3 μM for TXNDC5, and 25.4 μM for PDIA6. This compound is particularly valuable in research related to apoptosis induction and has demonstrated anti-myeloma properties.
(E/Z)-E64FC26 is a mixture of E-E64FC26 and Z-E64FC26, functioning as a potent pan-inhibitor of the protein disulfide isomerase (PDI) family. It exhibits significant biological activity with IC50 values of 1.9 μM for PDIA1, 20.9 μM for PDIA3, 25.9 μM for PDIA4, 16.3 μM for TXNDC5, and 25.4 μM for PDIA6. This compound is particularly valuable in research related to apoptosis induction and has demonstrated anti-myeloma properties.
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