Fig. 1 · Structure
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Mepazine
Apoptosis Inducer
Mepazine is a selective inhibitor of MALT1 protease, demonstrating IC50 values of 0.83 and 0.42 μM for full-length GSTMALT1 and the GSTMALT1 325-760 fragment, respectively. This compound effectively enhances apoptosis and reduces the viability of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cells. Mepazine serves as a valuable tool for investigating apoptosis mechanisms and potential therapeutic applications in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 60-89-9 |
| Applications | Apoptosis Inducer |
| Formula | C19H22N2S |
| Molecular Weight | 310.46 |
| Synonyms | Pecazine |
| SMILES | CN1CC(CCC1)CN2C3=C(SC4=CC=CC=C24)C=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.