Catalog No.
Product Name
Application
Product Information
Citations
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Carbonic Anhydrase Inhibitor
Clofenamide is a potent inhibitor of carbonic anhydrase (CA), an enzyme involved in maintaining acid-base balance and fluid homeostasis. This compound displays significant diuretic activity, making it valuable in research related to renal function and fluid regulation. Clofenamide is utilized in studies investigating the role of carbonic anhydrase in various physiological and pathological conditions. -
Carbonic Anhydrase Inhibitor
(Rac)-Sezolamide hydrochloride is a potent inhibitor of carbonic anhydrase, with a Ki value of 12.0 nM. This compound effectively lowers intraocular pressure (IOP), making it valuable for research into glaucoma and related ocular conditions. Its mechanism of action provides a useful tool for investigating the physiological and pharmacological pathways involved in eye health and disease. -
Human Carbonic Anhydrase Inhibitors
hCAI/II/XII-IN-1 is a potent inhibitor of human carbonic anhydrases I, II, and XII, exhibiting Ki values of 78.5 nM, 9.1 nM, 605 nM, 7.7 nM, and 3.7 nM for each isoform respectively. This compound demonstrates significant biological activity that can be leveraged in research applications targeting metabolic regulation, pH balance, and various diseases such as glaucoma and cancer. Its specificity and efficacy make it a valuable tool for investigating the role of carbonic anhydrases in physiological and pathological processes. -
Carbonic Anhydrase Inhibitor
Carbonic Anhydrase Inhibitor 12 is a selective inhibitor of carbonic anhydrase II (CA II), exhibiting a Ki value of 1.72 nM, and also demonstrating inhibitory activity against carbonic anhydrase I (CA I) with a Ki of 271 nM. This compound displays significant anticancer activity across various cancer cell lines, making it a valuable tool for cancer research and therapeutic development. Its ability to selectively target carbonic anhydrases influences pH regulation and may contribute to tumor growth modulation. -
Carbonic Anhydrase Inhibitor
Carbonic Anhydrase Inhibitor 9 is a selective inhibitor of carbonic anhydrases II and IX, exhibiting Ki values of 56.4 nM and 56.9 nM, respectively. This compound has demonstrated significant antiproliferative activity, making it a valuable tool for studying the role of carbonic anhydrases in cancer research and cellular metabolism. It serves as a potential therapeutic agent in conditions where modulation of carbonic anhydrase activity is desired. -
Carbonic Anhydrase Inhibitor
Carbonic Anhydrase Inhibitor 7 is a highly effective inhibitor of human carbonic anhydrase enzymes, with inhibition constants (Kis) of 6.5 nM for hCA IX, 7.1 nM for hCA II, 72.1 nM for hCA XII, and 255.8 nM for hCA I. This compound exhibits potent biological activity, making it a valuable tool for investigating the role of carbonic anhydrases in various physiological and pathological processes. It is particularly useful in cancer research and related fields where hCA IX is implicated. -
Carbonic Anhydrase Inhibitor
Sezolamide hydrochloride is a potent inhibitor of the enzyme carbonic anhydrase, primarily utilized in the context of ocular research. This compound effectively reduces intraocular pressure, making it valuable for studies related to glaucoma and other conditions affecting eye health. Sezolamide hydrochloride is instrumental in investigating the physiological mechanisms and therapeutic strategies for managing elevated ocular pressure. -
Carbonic Anhydrase 2 Inhibitor
GV2-20 is a potent inhibitor of Carbonic Anhydrase 2, demonstrating significant antiproliferative effects in chronic myeloid leukemia (CML) cells. This compound is valuable for research applications aimed at understanding the role of carbonic anhydrases in cancer biology and exploring potential therapeutic strategies for CML. Its selective inhibition may provide insights into cellular metabolism and proliferation mechanisms associated with cancer progression. -
Carbonic Anhydrase Inhibitor
Carbonic Anhydrase Inhibitor 4 is a selective inhibitor targeting human carbonic anhydrases (hCA I-XIV). With Ki values ranging from 640 to 1166 nM, it effectively modulates carbonic anhydrase activity. This compound is suitable for research applications involving enzyme inhibition studies and the investigation of physiological processes regulated by carbonic anhydrases. -
Carbonic Anhydrase Inhibitor
hCAIX-IN-10 is a selective inhibitor of carbonic anhydrases IX and XII, exhibiting Ki values of 61.5 nM and 586.8 nM for hCA IX and hCA XII, respectively. As transmembrane isoforms, hCA IX and hCA XII are recognized as key biomarkers for various tumors. The inhibition of these enzymes is pivotal in research focused on tumor progression, acid-base balance, and potential therapeutic strategies targeting cancer metabolism. -
Carbonic Anhydrase Inhibitor
Carbonic anhydrase inhibitor 6 is a potent inhibitor of human carbonic anhydrases (hCAs), exhibiting Ki values of 9.7 nM for hCA IX, 35.2 nM for hCA II, 88.5 nM for hCA XII, and 91.8 nM for hCA I. This compound is valuable for research applications targeting hCA-related pathways in cancer, glaucoma, and other diseases where carbonic anhydrases play a crucial role in regulating pH and fluid balance. Its high specificity and potency make it an essential tool for biochemical investigations and drug development efforts focusing on hCA modulation. -
Carbonic Anhydrase Inhibitor
Aminozolamide is a potent carbonic anhydrase inhibitor that plays a critical role in regulating intraocular pressure. By inhibiting carbonic anhydrase activity, Aminozolamide demonstrates effective local ocular effects and shows favorable retention within the ciliary body in rabbit models, reducing rapid elimination from the eye. This compound is applicable in the study of ocular hypertension and provides valuable insights into therapeutic interventions for managing elevated intraocular pressure. -
α-Carbonic Anhydrase Inhibitor
CAI0019 is an orally active inhibitor of α-carbonic anhydrase, designed based on the Acetazolamide framework. It demonstrates narrow-spectrum antibiofilm activity, with a MIC50 of 0.094 μM and a MIC90 of 0.39 μM. In a septic peritonitis mouse model, CAI0019 selectively inhibits Enterococcus while sparing most intestinal commensal bacteria, making it a valuable tool for research into antimicrobial therapies and biofilm-associated infections. -
Carbonic Anhydrase Inhibitor
Sezolamide is a potent inhibitor of carbonic anhydrase, primarily utilized for its ability to reduce intraocular pressure. Its mechanism of action involves the inhibition of carbonic anhydrase enzymes, which play a critical role in the regulation of bicarbonate and fluid balance in ocular tissues. This compound is valuable in research studies focused on glaucoma and other conditions associated with elevated intraocular pressure. -
Carbonic Anhydrase Inhibitor
(E)-Dehydrodiconiferyl alcohol is a dual inhibitor of human carbonic anhydrases IX and XII. This compound demonstrates significant biological activity by inhibiting NF-κB nuclear translocation in the connective tissues of healing areas. Its unique mechanism supports research in cancer biology and therapeutic approaches for inflammatory conditions. -
β-Carbonic Anhydrase Inhibitor
FC14-584B is a dithiocarbamate that serves as a β-Carbonic Anhydrase inhibitor. It effectively inhibits the growth of trophozoites and is applicable in research pertaining to tuberculosis. This compound may provide insights into the therapeutic approaches for diseases associated with dysregulated carbonic anhydrase activity. -
Carbonic Anhydrase Inhibitor
L-645151 is a carbonic anhydrase inhibitor that demonstrates significant ocular penetration and hypotensive activity. This compound effectively reduces elevated intraocular pressure (IOP) in o-chymotripsinized rabbit eyes, making it a valuable tool for research into ocular hypotensive agents. Its mechanism supports investigations aimed at treating conditions associated with increased IOP. -
Carbonic Anhydrase Inhibitor
(Rac)-Sezolamide is a potent carbonic anhydrase inhibitor (CAI) with a Ki value of 12.0 nM. It exhibits significant topical intraocular pressure (IOP) lowering effects, making it a valuable tool in the study of glaucoma and related ocular conditions. Researchers can utilize (Rac)-Sezolamide to explore pathways involved in IOP regulation and to develop therapeutic strategies for managing glaucoma. -
Carbonic Anhydrase Inhibitor
Chloraminophenamide is a potent inhibitor of carbonic anhydrase, demonstrating Ki values of 75 nM for human carbonic anhydrase II (hCA II), 160 nM for bovine carbonic anhydrase IV (bCA IV), and 8400 nM for human carbonic anhydrase I (hCA I). This compound holds promise for antiglaucoma research, owing to its ability to modulate carbonic anhydrase activity, which plays a crucial role in ocular pressure regulation. Its specificity toward hCA II and bCA IV makes it a valuable tool for studying the therapeutic potential in ocular disorders. -
Carbonic Anhydrase Inhibitor
Chlorthalidone Impurity G is identified as a carbonic anhydrase inhibitor. This compound exhibits moderate antihypertensive effects and is found as a potential impurity in commercial preparations of chlorthalidone. Its primary mechanism involves the inhibition of the Na+/Cl- cotransporter in the kidney's distal tubule, leading to reduced sodium and chloride reabsorption, which ultimately decreases plasma volume and cardiac output. Additionally, it primarily inhibits carbonic anhydrase isoenzymes CAVB, VII, IX, XII, and XIII, with K_i values ranging from 2.8 to 23 nM, thereby contributing to its vasodilatory properties. -
Carbonic anhydrase Inhibitor
N-Desethyl Brinzolamide oxalate is a potent inhibitor of carbonic anhydrase II and carbonic anhydrase IV, demonstrating IC50 values of 1.28 nM and 128 nM, respectively. This compound is valuable for research involving the regulation of bicarbonate and pH balance in physiological systems. It is commonly utilized in studies related to glaucoma treatment and other conditions influenced by carbonic anhydrase activity. -
Carbonic Anhydrase Inhibitor
Carbonic Anhydrase Inhibitor 22 is a sulfonamide compound that selectively inhibits carbonic anhydrases, with Ki values of 762 nM for hCA I, 20.3 nM for hCA II, 8.3 nM for hCA VII, 17.9 nM for hCA IX, and 10.5 nM for hCA XII. This compound's potent inhibition of multiple isoforms of carbonic anhydrase makes it valuable for studying biochemical pathways involving pH regulation and ion transport. It serves as a useful tool in research related to metabolic disorders, cancer, and other conditions where carbonic anhydrases play a critical role. -
Carbonic Anhydrase Inhibitor
L-662583 is a selective inhibitor of carbonic anhydrase II, exhibiting a potent inhibitory effect with an IC50 value of 0.7 nM. This compound serves as a valuable tool for studying the role of carbonic anhydrases in physiological processes and disease models, particularly in conditions related to acid-base balance and fluid secretion. It is applicable in biochemical research and drug development targeting carbonic anhydrase-related pathways. -
Carbonic Anhydrase Inhibitor
Indan-5-sulphonamide is a potent inhibitor of carbonic anhydrase, demonstrating Ki values of 0.039 nM for hCA XII, 6.5 nM for hCA XIV, and 5.1 nM for additional isoforms. This compound exhibits anticonvulsant properties and is valuable in research applications focused on enzyme inhibition and neurological studies. Its high selectivity and efficacy make it a key reagent for investigating the role of carbonic anhydrases in various biological processes. -
Carbonic anhydrase inhibitor
Carbonic anhydrase inhibitor 19 is a potent inhibitor of the carbonic anhydrase isoforms hCA II and hCA XII, demonstrating inhibitory constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound exhibits significant biological activity by effectively lowering intraocular pressure (IOP), making it a valuable tool for research in glaucoma treatment and related ocular conditions. Its selective inhibition profile allows for the exploration of therapeutic strategies targeting carbonic anhydrases in various biological contexts. -
Acetylcholinesterase Inhibitor, Butyrylcholinesterase Inhibitor, Carbonic Anhydrase I/II Inhibitor, α-Glycosidase Inhibitor
Vescalagin is a hexahydroxyphenol that acts as an inhibitor of acetylcholinesterase and butyrylcholinesterase, as well as carbonic anhydrases I and II, and α-glycosidase. It demonstrates potent inhibitory activity with Ki values of 5.87 nM for AChE, 3.89 nM for BChE, 11.75 nM for hCA I, 16.23 nM for hCA II, and 16.08 nM for α-glycosidase. Vescalagin exhibits non-competitive inhibition for hCA I, hCA II, and α-glycosidase, while also reducing hyperglycemia and hypertriglyceridemia in dietary models. Additionally, it possesses anti-inflammatory and antioxidant activities, making it a valuable compound for research in diabetes and metabolic disorders.
