Fig. 1 · Structure
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Chlorthalidone Impurity G
Carbonic Anhydrase Inhibitor
Chlorthalidone Impurity G is identified as a carbonic anhydrase inhibitor. This compound exhibits moderate antihypertensive effects and is found as a potential impurity in commercial preparations of chlorthalidone. Its primary mechanism involves the inhibition of the Na+/Cl- cotransporter in the kidney's distal tubule, leading to reduced sodium and chloride reabsorption, which ultimately decreases plasma volume and cardiac output. Additionally, it primarily inhibits carbonic anhydrase isoenzymes CAVB, VII, IX, XII, and XIII, with K_i values ranging from 2.8 to 23 nM, thereby contributing to its vasodilatory properties.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 16289-13-7 |
| Applications | Carbonic Anhydrase Inhibitor |
| Formula | C14H9Cl2NO2 |
| Molecular Weight | 294.13 |
| Synonyms | Chlorthalidone EP Impurity G |
| SMILES | O=C1NC(O)(C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.