Chlorthalidone Impurity G is identified as a carbonic anhydrase inhibitor. This compound exhibits moderate antihypertensive effects and is found as a potential impurity in commercial preparations of chlorthalidone. Its primary mechanism involves the inhibition of the Na+/Cl- cotransporter in the kidney's distal tubule, leading to reduced sodium and chloride reabsorption, which ultimately decreases plasma volume and cardiac output. Additionally, it primarily inhibits carbonic anhydrase isoenzymes CAVB, VII, IX, XII, and XIII, with K_i values ranging from 2.8 to 23 nM, thereby contributing to its vasodilatory properties.
Chlorthalidone Impurity G is identified as a carbonic anhydrase inhibitor. This compound exhibits moderate antihypertensive effects and is found as a potential impurity in commercial preparations of chlorthalidone. Its primary mechanism involves the inhibition of the Na+/Cl- cotransporter in the kidney's distal tubule, leading to reduced sodium and chloride reabsorption, which ultimately decreases plasma volume and cardiac output. Additionally, it primarily inhibits carbonic anhydrase isoenzymes CAVB, VII, IX, XII, and XIII, with K_i values ranging from 2.8 to 23 nM, thereby contributing to its vasodilatory properties.
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