Fig. 1 · Structure
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Carbonic anhydrase inhibitor 12
Carbonic Anhydrase Inhibitor
Carbonic Anhydrase Inhibitor 12 is a selective inhibitor of carbonic anhydrase II (CA II), exhibiting a Ki value of 1.72 nM, and also demonstrating inhibitory activity against carbonic anhydrase I (CA I) with a Ki of 271 nM. This compound displays significant anticancer activity across various cancer cell lines, making it a valuable tool for cancer research and therapeutic development. Its ability to selectively target carbonic anhydrases influences pH regulation and may contribute to tumor growth modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2883451-38-3 |
| Applications | Carbonic Anhydrase Inhibitor |
| Formula | C27H22BrN5O5S2 |
| Molecular Weight | 640.53 |
| SMILES | COC1=CC=C(C(C2=NC(SCC(C3=CC=C(C=C3)Br)=O)=NC(NC4=CC=C(C=C4)S(N)(=O)=O)=C2C#N)=C1)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.