Fig. 1 · Structure
Documents & Downloads
2-Iodoestradiol
Cat. No.
A74412
CAS
24381-12-2
Endogenous Metabolite
2-Iodoestradiol is a potent ligand for human sex hormone binding globulin (SHBG) with a high binding affinity, demonstrating competition with dihydrotestosterone at the same site on SHBG. Its binding affinity constant at physiological pH and 37 degrees Celsius is 2.4 x 10^9 M^-1, surpassing that of SHBG itself. Additionally, 2-Iodoestradiol can bind to serum albumin, although with reduced affinity. The radioisotope 125I-derivative of this compound is commonly employed in studies investigating the binding dynamics of human SHBG, making it a valuable tool for biological research applications.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 24381-12-2 |
| Applications | Endogenous Metabolite |
| Formula | C18H23IO2 |
| Molecular Weight | 398.28 |
| SMILES | C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(I)=C(O)C=C4CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.