2-Iodoestradiol is a potent ligand for human sex hormone binding globulin (SHBG) with a high binding affinity, demonstrating competition with dihydrotestosterone at the same site on SHBG. Its binding affinity constant at physiological pH and 37 degrees Celsius is 2.4 x 10^9 M^-1, surpassing that of SHBG itself. Additionally, 2-Iodoestradiol can bind to serum albumin, although with reduced affinity. The radioisotope 125I-derivative of this compound is commonly employed in studies investigating the binding dynamics of human SHBG, making it a valuable tool for biological research applications.
2-Iodoestradiol is a potent ligand for human sex hormone binding globulin (SHBG) with a high binding affinity, demonstrating competition with dihydrotestosterone at the same site on SHBG. Its binding affinity constant at physiological pH and 37 degrees Celsius is 2.4 x 10^9 M^-1, surpassing that of SHBG itself. Additionally, 2-Iodoestradiol can bind to serum albumin, although with reduced affinity. The radioisotope 125I-derivative of this compound is commonly employed in studies investigating the binding dynamics of human SHBG, making it a valuable tool for biological research applications.
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