Fig. 1 · Structure
Documents & Downloads
Scio-323
Cat. No.
A74368
CAS
309913-51-7
Endogenous Metabolite
Scio-323 is an orally active inhibitor of the p38 mitogen-activated protein kinase (MAPK), primarily targeting chronic inflammatory responses linked to polyethylene particles. This compound has demonstrated the ability to reduce inflammation; however, it shows minimal impact on bone formation during such responses. Notably, Scio-323 treatment does not enhance bone growth in the presence of polyethylene particles, and osteoblast-like activity remains suppressed. This positions Scio-323 as a significant candidate for research into chronic inflammatory conditions affecting bone metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 309913-51-7 |
| Applications | Endogenous Metabolite |
| Formula | C27H30FN3O4 |
| Molecular Weight | 479.54 |
| SMILES | O=C(C1=CN(C)C2=C1C=C(C(N3CCC(CC3)CC4=CC=C(C=C4)F)=O)C(OC)=C2)C(N(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.