(+/-) 13-HODE cholesteryl ester is an endogenous metabolite derived from atherosclerotic lesions, produced through the Cu2+-catalyzed oxidation of low-density lipoprotein (LDL). It is synthesized by the action of lipoxygenase enzymes, particularly 15-lipoxygenase from rabbit reticulocytes and human monocytes, acting on cholesteryl linoleate, a key component of LDL. This compound is essential for studying lipid metabolism and the pathophysiological mechanisms involved in atherosclerosis and related cardiovascular conditions.
(+/-) 13-HODE cholesteryl ester is an endogenous metabolite derived from atherosclerotic lesions, produced through the Cu2+-catalyzed oxidation of low-density lipoprotein (LDL). It is synthesized by the action of lipoxygenase enzymes, particularly 15-lipoxygenase from rabbit reticulocytes and human monocytes, acting on cholesteryl linoleate, a key component of LDL. This compound is essential for studying lipid metabolism and the pathophysiological mechanisms involved in atherosclerosis and related cardiovascular conditions.
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