Deacetyldiltiazem is an endogenous metabolite primarily acting as a coronary vasodilator. It is found in the plasma of individuals treated with Diltiazem and is metabolized via deacetylation, primarily catalyzed by the rat Ces2a enzyme. In vitro studies reveal that Deacetyldiltiazem exhibits efficient deacetylase activity, with Km values comparable to those observed in rat liver microsomes. Research on Deacetyldiltiazem contributes to the understanding of metabolic kinetic variations of compounds across different species.
Deacetyldiltiazem is an endogenous metabolite primarily acting as a coronary vasodilator. It is found in the plasma of individuals treated with Diltiazem and is metabolized via deacetylation, primarily catalyzed by the rat Ces2a enzyme. In vitro studies reveal that Deacetyldiltiazem exhibits efficient deacetylase activity, with Km values comparable to those observed in rat liver microsomes. Research on Deacetyldiltiazem contributes to the understanding of metabolic kinetic variations of compounds across different species.
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